The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients
Identifieur interne : 001760 ( PascalFrancis/Corpus ); précédent : 001759; suivant : 001761The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients
Auteurs : O. Rascol ; U. Sabatini ; N. Fabre ; C. Brefel ; I. Loubinoux ; P. Celsis ; J. M. Senard ; J. L. Montastruc ; F. CholletSource :
- Brain [ 0006-8950 ] ; 1997.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
We compared the rCBF changes induced by the execution of a finger-to-thumb opposition motor task in the cerebellar hemispheres of 12 normal subjects, 12 parkinsonian patients whose medication had been withheld for at least 18 h and 16 parkinsonian patients on medication using single photon emission tomography and i.v. 133Xe. The normal subjects and parkinsonian patients on medication exhibited the same pattern of response, with a significant increase in rCBF in the contralateral primary motor cortex and in the supplementary motor areas. No significant rCBF change was detected in the cerebellum of these two groups; this finding was expected since our technique cannot detect cerebellar activation when the motor task is executed at a relatively, low rate and small amplitude as it was in this study. The parkinsonian patients off medication exhibited a markedly different pattern of activation characterized by a significant overactivation in the ipsilateral cerebellar hemisphere and a significant underactivation in the supplementary motor areas. These results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays.
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Format Inist (serveur)
NO : | PASCAL 97-0171682 INIST |
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ET : | The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients |
AU : | RASCOL (O.); SABATINI (U.); FABRE (N.); BREFEL (C.); LOUBINOUX (I.); CELSIS (P.); SENARD (J. M.); MONTASTRUC (J. L.); CHOLLET (F.) |
AF : | Department of Medical and Clinical Pharmacology, University Hospital/Toulouse/France (1 aut., 4 aut., 7 aut., 8 aut.); INSERM U455, University Hospital/Toulouse/France (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 9 aut.); Istituto Mediterraneo di Neuroscienze Sanatrix/Pozzili/Italie (2 aut.); Departments of Neurology, University Hospital/Toulouse/France |
DT : | Publication en série; Niveau analytique |
SO : | Brain; ISSN 0006-8950; Royaume-Uni; Da. 1997; Vol. 120; No. p.1; Pp. 103-110; Bibl. 1 p.1/2 |
LA : | Anglais |
EA : | We compared the rCBF changes induced by the execution of a finger-to-thumb opposition motor task in the cerebellar hemispheres of 12 normal subjects, 12 parkinsonian patients whose medication had been withheld for at least 18 h and 16 parkinsonian patients on medication using single photon emission tomography and i.v. 133Xe. The normal subjects and parkinsonian patients on medication exhibited the same pattern of response, with a significant increase in rCBF in the contralateral primary motor cortex and in the supplementary motor areas. No significant rCBF change was detected in the cerebellum of these two groups; this finding was expected since our technique cannot detect cerebellar activation when the motor task is executed at a relatively, low rate and small amplitude as it was in this study. The parkinsonian patients off medication exhibited a markedly different pattern of activation characterized by a significant overactivation in the ipsilateral cerebellar hemisphere and a significant underactivation in the supplementary motor areas. These results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays. |
CC : | 002B17G |
FD : | Parkinson maladie; Akinésie; Mouvement; Main; Tomoscintigraphie; Photon; Débit sanguin régional; Cervelet; Exploration; Homme |
FG : | Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Trouble neurologique; Trouble moteur; Exploration radioisotopique; Hémodynamique |
ED : | Parkinson disease; Akinesia; Motion; Hand; Emission tomography; Photon; Regional blood flow; Cerebellum; Exploration; Human |
EG : | Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Neurological disorder; Motor system disorder; Radionuclide study; Hemodynamics |
GD : | Bewegung; Photon |
SD : | Parkinson enfermedad; Aquinesia; Movimiento; Mano; Tomocentelleografía; Fotón; Flujo sanguíneo regional; Cerebelo; Exploración; Hombre |
LO : | INIST-998.354000063119560090 |
ID : | 97-0171682 |
Links to Exploration step
Pascal:97-0171682Le document en format XML
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<front><div type="abstract" xml:lang="en">We compared the rCBF changes induced by the execution of a finger-to-thumb opposition motor task in the cerebellar hemispheres of 12 normal subjects, 12 parkinsonian patients whose medication had been withheld for at least 18 h and 16 parkinsonian patients on medication using single photon emission tomography and i.v. <sup>133</sup>
Xe. The normal subjects and parkinsonian patients on medication exhibited the same pattern of response, with a significant increase in rCBF in the contralateral primary motor cortex and in the supplementary motor areas. No significant rCBF change was detected in the cerebellum of these two groups; this finding was expected since our technique cannot detect cerebellar activation when the motor task is executed at a relatively, low rate and small amplitude as it was in this study. The parkinsonian patients off medication exhibited a markedly different pattern of activation characterized by a significant overactivation in the ipsilateral cerebellar hemisphere and a significant underactivation in the supplementary motor areas. These results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays.</div>
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<s5>07</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Motion</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="GER"><s0>Bewegung</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Movimiento</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Main</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Hand</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Mano</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Tomoscintigraphie</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Emission tomography</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Tomocentelleografía</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Photon</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Photon</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="GER"><s0>Photon</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Fotón</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Débit sanguin régional</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Regional blood flow</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Flujo sanguíneo regional</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Cervelet</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Cerebellum</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Cerebelo</s0>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Exploration</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Exploration</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Exploración</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Homme</s0>
<s5>20</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Human</s0>
<s5>20</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Hombre</s0>
<s5>20</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>48</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>48</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>48</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Trouble moteur</s0>
<s5>49</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Motor system disorder</s0>
<s5>49</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Trastorno motor</s0>
<s5>49</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Exploration radioisotopique</s0>
<s5>61</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Radionuclide study</s0>
<s5>61</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Exploración radioisotópica</s0>
<s5>61</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Hémodynamique</s0>
<s5>69</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Hemodynamics</s0>
<s5>69</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Hemodinámica</s0>
<s5>69</s5>
</fC07>
<fN21><s1>083</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 97-0171682 INIST</NO>
<ET>The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients</ET>
<AU>RASCOL (O.); SABATINI (U.); FABRE (N.); BREFEL (C.); LOUBINOUX (I.); CELSIS (P.); SENARD (J. M.); MONTASTRUC (J. L.); CHOLLET (F.)</AU>
<AF>Department of Medical and Clinical Pharmacology, University Hospital/Toulouse/France (1 aut., 4 aut., 7 aut., 8 aut.); INSERM U455, University Hospital/Toulouse/France (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 9 aut.); Istituto Mediterraneo di Neuroscienze Sanatrix/Pozzili/Italie (2 aut.); Departments of Neurology, University Hospital/Toulouse/France</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Brain; ISSN 0006-8950; Royaume-Uni; Da. 1997; Vol. 120; No. p.1; Pp. 103-110; Bibl. 1 p.1/2</SO>
<LA>Anglais</LA>
<EA>We compared the rCBF changes induced by the execution of a finger-to-thumb opposition motor task in the cerebellar hemispheres of 12 normal subjects, 12 parkinsonian patients whose medication had been withheld for at least 18 h and 16 parkinsonian patients on medication using single photon emission tomography and i.v. <sup>133</sup>
Xe. The normal subjects and parkinsonian patients on medication exhibited the same pattern of response, with a significant increase in rCBF in the contralateral primary motor cortex and in the supplementary motor areas. No significant rCBF change was detected in the cerebellum of these two groups; this finding was expected since our technique cannot detect cerebellar activation when the motor task is executed at a relatively, low rate and small amplitude as it was in this study. The parkinsonian patients off medication exhibited a markedly different pattern of activation characterized by a significant overactivation in the ipsilateral cerebellar hemisphere and a significant underactivation in the supplementary motor areas. These results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays.</EA>
<CC>002B17G</CC>
<FD>Parkinson maladie; Akinésie; Mouvement; Main; Tomoscintigraphie; Photon; Débit sanguin régional; Cervelet; Exploration; Homme</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Trouble neurologique; Trouble moteur; Exploration radioisotopique; Hémodynamique</FG>
<ED>Parkinson disease; Akinesia; Motion; Hand; Emission tomography; Photon; Regional blood flow; Cerebellum; Exploration; Human</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Neurological disorder; Motor system disorder; Radionuclide study; Hemodynamics</EG>
<GD>Bewegung; Photon</GD>
<SD>Parkinson enfermedad; Aquinesia; Movimiento; Mano; Tomocentelleografía; Fotón; Flujo sanguíneo regional; Cerebelo; Exploración; Hombre</SD>
<LO>INIST-998.354000063119560090</LO>
<ID>97-0171682</ID>
</server>
</inist>
</record>
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