A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson’s disease
Identifieur interne : 001331 ( Main/Exploration ); précédent : 001330; suivant : 001332A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson’s disease
Auteurs : H. Pouclet [France] ; T. Lebouvier [France] ; E. Coron [France] ; S. B. Des Varannes [France] ; M. Neunlist [France] ; P. Derkinderen [France]Source :
- Neurogastroenterology & Motility [ 1350-1925 ] ; 2012-04.
English descriptors
- KwdEn :
- Adult, Aged, Colon (pathology), Female, Humans, Immunohistochemistry, Intestinal Mucosa (pathology), Lewy Bodies (pathology), Male, Microdissection, Middle Aged, Neurites (pathology), Parkinson Disease (pathology), Parkinson’s disease, Submucous Plexus (pathology), biomarker, biopsies, colon, mucosa, submucosal plexus.
- MESH :
- pathology : Colon, Intestinal Mucosa, Lewy Bodies, Neurites, Parkinson Disease, Submucous Plexus.
- Adult, Aged, Female, Humans, Immunohistochemistry, Male, Microdissection, Middle Aged.
Abstract
Background Lewy bodies and neurites (LN), the two pathological hallmarks of Parkinson’s disease (PD), are found in the enteric nervous system (ENS). Previously, we have shown that whole mounts of submucosa obtained after microdissection of colonic biopsies can be used for the detection of LN in the submucosal plexus (SMP) of PD patients. Recent reports suggest that Lewy pathology may extend beyond the submucosa to involve the digestive mucosa. The aim of the present research was to determine whether the analysis of the mucosa obtained after microdissection may help improve the sensitivity of colonic biopsies to detect Lewy pathology in the colon of PD patients.
Url:
DOI: 10.1111/j.1365-2982.2012.01887.x
Affiliations:
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Neunlist</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U913, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Nantes University, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Institut des Maladies de l’Appareil Digestif, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Derkinderen, P" sort="Derkinderen, P" uniqKey="Derkinderen P" first="P." last="Derkinderen">P. Derkinderen</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U913, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CIC‐04, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Nantes University, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Department of Neurology, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Institut des Maladies de l’Appareil Digestif, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Neurogastroenterology & Motility</title><idno type="ISSN">1350-1925</idno><idno type="eISSN">1365-2982</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-04">2012-04</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="202">e202</biblScope><biblScope unit="page" to="205">e205</biblScope></imprint><idno type="ISSN">1350-1925</idno></series><idno type="istex">C82A33BD5A608F43313CFD809D984D6E0A50EDFE</idno><idno type="DOI">10.1111/j.1365-2982.2012.01887.x</idno><idno type="ArticleID">NMO1887</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1350-1925</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Colon (pathology)</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Intestinal Mucosa (pathology)</term><term>Lewy Bodies (pathology)</term><term>Male</term><term>Microdissection</term><term>Middle Aged</term><term>Neurites (pathology)</term><term>Parkinson Disease (pathology)</term><term>Parkinson’s disease</term><term>Submucous Plexus (pathology)</term><term>biomarker</term><term>biopsies</term><term>colon</term><term>mucosa</term><term>submucosal plexus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colon</term><term>Intestinal Mucosa</term><term>Lewy Bodies</term><term>Neurites</term><term>Parkinson Disease</term><term>Submucous Plexus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Microdissection</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background Lewy bodies and neurites (LN), the two pathological hallmarks of Parkinson’s disease (PD), are found in the enteric nervous system (ENS). Previously, we have shown that whole mounts of submucosa obtained after microdissection of colonic biopsies can be used for the detection of LN in the submucosal plexus (SMP) of PD patients. Recent reports suggest that Lewy pathology may extend beyond the submucosa to involve the digestive mucosa. The aim of the present research was to determine whether the analysis of the mucosa obtained after microdissection may help improve the sensitivity of colonic biopsies to detect Lewy pathology in the colon of PD patients.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Pays de la Loire</li></region><settlement><li>Nantes</li></settlement></list><tree><country name="France"><region name="Pays de la Loire"><name sortKey="Pouclet, H" sort="Pouclet, H" uniqKey="Pouclet H" first="H." last="Pouclet">H. Pouclet</name></region><name sortKey="Coron, E" sort="Coron, E" uniqKey="Coron E" first="E." last="Coron">E. Coron</name><name sortKey="Coron, E" sort="Coron, E" uniqKey="Coron E" first="E." last="Coron">E. Coron</name><name sortKey="Coron, E" sort="Coron, E" uniqKey="Coron E" first="E." last="Coron">E. Coron</name><name sortKey="Coron, E" sort="Coron, E" uniqKey="Coron E" first="E." last="Coron">E. Coron</name><name sortKey="Derkinderen, P" sort="Derkinderen, P" uniqKey="Derkinderen P" first="P." last="Derkinderen">P. Derkinderen</name><name sortKey="Derkinderen, P" sort="Derkinderen, P" uniqKey="Derkinderen P" first="P." last="Derkinderen">P. Derkinderen</name><name sortKey="Derkinderen, P" sort="Derkinderen, P" uniqKey="Derkinderen P" first="P." last="Derkinderen">P. Derkinderen</name><name sortKey="Derkinderen, P" sort="Derkinderen, P" uniqKey="Derkinderen P" first="P." last="Derkinderen">P. Derkinderen</name><name sortKey="Derkinderen, P" sort="Derkinderen, P" uniqKey="Derkinderen P" first="P." last="Derkinderen">P. Derkinderen</name><name sortKey="Des Varannes, S B" sort="Des Varannes, S B" uniqKey="Des Varannes S" first="S. B." last="Des Varannes">S. B. Des Varannes</name><name sortKey="Des Varannes, S B" sort="Des Varannes, S B" uniqKey="Des Varannes S" first="S. B." last="Des Varannes">S. B. Des Varannes</name><name sortKey="Des Varannes, S B" sort="Des Varannes, S B" uniqKey="Des Varannes S" first="S. B." last="Des Varannes">S. B. Des Varannes</name><name sortKey="Des Varannes, S B" sort="Des Varannes, S B" uniqKey="Des Varannes S" first="S. B." last="Des Varannes">S. B. Des Varannes</name><name sortKey="Lebouvier, T" sort="Lebouvier, T" uniqKey="Lebouvier T" first="T." last="Lebouvier">T. Lebouvier</name><name sortKey="Lebouvier, T" sort="Lebouvier, T" uniqKey="Lebouvier T" first="T." last="Lebouvier">T. Lebouvier</name><name sortKey="Lebouvier, T" sort="Lebouvier, T" uniqKey="Lebouvier T" first="T." last="Lebouvier">T. Lebouvier</name><name sortKey="Lebouvier, T" sort="Lebouvier, T" uniqKey="Lebouvier T" first="T." last="Lebouvier">T. Lebouvier</name><name sortKey="Neunlist, M" sort="Neunlist, M" uniqKey="Neunlist M" first="M." last="Neunlist">M. Neunlist</name><name sortKey="Neunlist, M" sort="Neunlist, M" uniqKey="Neunlist M" first="M." last="Neunlist">M. Neunlist</name><name sortKey="Neunlist, M" sort="Neunlist, M" uniqKey="Neunlist M" first="M." last="Neunlist">M. Neunlist</name><name sortKey="Pouclet, H" sort="Pouclet, H" uniqKey="Pouclet H" first="H." last="Pouclet">H. Pouclet</name><name sortKey="Pouclet, H" sort="Pouclet, H" uniqKey="Pouclet H" first="H." last="Pouclet">H. Pouclet</name><name sortKey="Pouclet, H" sort="Pouclet, H" uniqKey="Pouclet H" first="H." last="Pouclet">H. Pouclet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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