A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson’s disease
Identifieur interne : 000405 ( Istex/Curation ); précédent : 000404; suivant : 000406A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson’s disease
Auteurs : H. Pouclet [France] ; T. Lebouvier [France] ; E. Coron [France] ; S. B. Des Varannes [France] ; M. Neunlist [France] ; P. Derkinderen [France]Source :
- Neurogastroenterology & Motility [ 1350-1925 ] ; 2012-04.
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Abstract
Background Lewy bodies and neurites (LN), the two pathological hallmarks of Parkinson’s disease (PD), are found in the enteric nervous system (ENS). Previously, we have shown that whole mounts of submucosa obtained after microdissection of colonic biopsies can be used for the detection of LN in the submucosal plexus (SMP) of PD patients. Recent reports suggest that Lewy pathology may extend beyond the submucosa to involve the digestive mucosa. The aim of the present research was to determine whether the analysis of the mucosa obtained after microdissection may help improve the sensitivity of colonic biopsies to detect Lewy pathology in the colon of PD patients.
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DOI: 10.1111/j.1365-2982.2012.01887.x
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Previously, we have shown that whole mounts of submucosa obtained after microdissection of colonic biopsies can be used for the detection of LN in the submucosal plexus (SMP) of PD patients. Recent reports suggest that Lewy pathology may extend beyond the submucosa to involve the digestive mucosa. The aim of the present research was to determine whether the analysis of the mucosa obtained after microdissection may help improve the sensitivity of colonic biopsies to detect Lewy pathology in the colon of PD patients.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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