Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease
Identifieur interne : 002C87 ( Main/Exploration ); précédent : 002C86; suivant : 002C88Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease
Auteurs : Maria Martinez [France] ; Alexis Brice [France] ; Jenny R. Vaughan [Royaume-Uni] ; Alexander Zimprich [Allemagne] ; Monique M. B. Breteler [Pays-Bas] ; Giuseppe Meco [Italie] ; Alessandro Filla [Italie] ; Matthew J. Farrer [États-Unis] ; Christine Bétard [France] ; Andrew Singleton [États-Unis] ; John Hardy [États-Unis] ; Giuseppe De Michele [Italie] ; Vincenzo Bonifati [Italie] ; Ben A. Oostra [Pays-Bas] ; Thomas Gasser [Allemagne] ; Nick W. Wood [Royaume-Uni] ; Alexandra Dürr [France]Source :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2005-07-05.
English descriptors
- KwdEn :
- Alleles, Apolipoprotein E4, Apolipoproteins E (genetics), Chromosomes, Human, Pair 19 (genetics), Family Health, Gene Frequency, Genetic Linkage, Genotype, Humans, Linkage Disequilibrium, Lod Score, Microsatellite Repeats, Parkinson Disease (genetics), Parkinson's disease, Siblings, apolipoprotein E, genetics.
- MESH :
- chemical , genetics : Apolipoproteins E.
- chemical : Apolipoprotein E4.
- genetics : Chromosomes, Human, Pair 19, Parkinson Disease.
- Alleles, Family Health, Gene Frequency, Genetic Linkage, Genotype, Humans, Linkage Disequilibrium, Lod Score, Microsatellite Repeats, Siblings.
Abstract
Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease. © 2005 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ajmg.b.30196
Affiliations:
- Allemagne, France, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Bade-Wurtemberg, District de Tübingen, Floride, Grand Londres, Hollande-Méridionale, Latium, Maryland, Île-de-France
- Londres, Paris, Rome, Rotterdam, Tübingen, Évry (Essonne)
- University College de Londres
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Vaughan</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Charing Cross Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, La Sapienza University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, Federico II University, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Neurogenetics Laboratory, Mayo Clinic Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Betard, Christine" sort="Betard, Christine" uniqKey="Betard C" first="Christine" last="Bétard">Christine Bétard</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Génotypage, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A1015, 35 Convent Drive, Room 1A1015 MSC 3707, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, Federico II University, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, La Sapienza University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Wood, Nick W" sort="Wood, Nick W" uniqKey="Wood N" first="Nick W." last="Wood">Nick W. Wood</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U289 and Département de Génétique, Cytogénétique et Embryologie, Hôpital La Pitité‐Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><title level="j" type="abbrev">Am. J. Med. Genet.</title><idno type="ISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-07-05">2005-07-05</date><biblScope unit="volume">136B</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="72">72</biblScope><biblScope unit="page" to="74">74</biblScope></imprint><idno type="ISSN">1552-4841</idno></series><idno type="istex">8597E6EA47C2A351548E63379CB0327F70791D8F</idno><idno type="DOI">10.1002/ajmg.b.30196</idno><idno type="ArticleID">AJMG30196</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-4841</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>Apolipoprotein E4</term><term>Apolipoproteins E (genetics)</term><term>Chromosomes, Human, Pair 19 (genetics)</term><term>Family Health</term><term>Gene Frequency</term><term>Genetic Linkage</term><term>Genotype</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Lod Score</term><term>Microsatellite Repeats</term><term>Parkinson Disease (genetics)</term><term>Parkinson's disease</term><term>Siblings</term><term>apolipoprotein E</term><term>genetics</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Apolipoprotein E4</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 19</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Family Health</term><term>Gene Frequency</term><term>Genetic Linkage</term><term>Genotype</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Lod Score</term><term>Microsatellite Repeats</term><term>Siblings</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease. © 2005 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>District de Tübingen</li><li>Floride</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Latium</li><li>Maryland</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Paris</li><li>Rome</li><li>Rotterdam</li><li>Tübingen</li><li>Évry (Essonne)</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name></region><name sortKey="Betard, Christine" sort="Betard, Christine" uniqKey="Betard C" first="Christine" last="Bétard">Christine Bétard</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Vaughan, Jenny R" sort="Vaughan, Jenny R" uniqKey="Vaughan J" first="Jenny R." last="Vaughan">Jenny R. Vaughan</name></region><name sortKey="Wood, Nick W" sort="Wood, Nick W" uniqKey="Wood N" first="Nick W." last="Wood">Nick W. Wood</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name></region><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name></region><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name></country><country name="Italie"><region name="Latium"><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name></region><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name></country><country name="États-Unis"><region name="Floride"><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name></region><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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