Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease
Identifieur interne : 000243 ( Istex/Curation ); précédent : 000242; suivant : 000244Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease
Auteurs : Maria Martinez [France] ; Alexis Brice [France] ; Jenny R. Vaughan [Royaume-Uni] ; Alexander Zimprich [Allemagne] ; Monique M. B. Breteler [Pays-Bas] ; Giuseppe Meco [Italie] ; Alessandro Filla [Italie] ; Matthew J. Farrer [États-Unis] ; Christine Bétard [France] ; Andrew Singleton [États-Unis] ; John Hardy [États-Unis] ; Giuseppe De Michele [Italie] ; Vincenzo Bonifati [Italie] ; Ben A. Oostra [Pays-Bas] ; Thomas Gasser [Allemagne] ; Nick W. Wood [Royaume-Uni] ; Alexandra Dürr [France]Source :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2005-07-05.
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Abstract
Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease. © 2005 Wiley‐Liss, Inc.
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DOI: 10.1002/ajmg.b.30196
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Vaughan</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Charing Cross Hospital, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Charing Cross Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name><affiliation wicri:level="1"><mods:affiliation>Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, La Sapienza University, Rome, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, La Sapienza University, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, Federico II University, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, Federico II University, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><mods:affiliation>Neurogenetics Laboratory, Mayo Clinic Jacksonville, Florida</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Neurogenetics Laboratory, Mayo Clinic Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Betard, Christine" sort="Betard, Christine" uniqKey="Betard C" first="Christine" last="Bétard">Christine Bétard</name><affiliation wicri:level="1"><mods:affiliation>Centre National de Génotypage, Evry, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Génotypage, Evry</wicri:regionArea></affiliation></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name><affiliation wicri:level="2"><mods:affiliation>Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, Maryland</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="2"><mods:affiliation>Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, Maryland</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda</wicri:cityArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A1015, 35 Convent Drive, Room 1A1015 MSC 3707, Bethesda, MD 20892‐3707.</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A1015, 35 Convent Drive, Room 1A1015 MSC 3707, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, Federico II University, Naples, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, Federico II University, Naples</wicri:regionArea></affiliation></author><author><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, La Sapienza University, Rome, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, La Sapienza University, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus MC, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases, Hertie‐Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Wood, Nick W" sort="Wood, Nick W" uniqKey="Wood N" first="Nick W." last="Wood">Nick W. Wood</name><affiliation wicri:level="1"><mods:affiliation>Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation wicri:level="1"><mods:affiliation>INSERM U289 and Département de Génétique, Cytogénétique et Embryologie, Hôpital La Pitité‐Salpêtrière, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U289 and Département de Génétique, Cytogénétique et Embryologie, Hôpital La Pitité‐Salpêtrière, Paris</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><title level="j" type="abbrev">Am. J. Med. Genet.</title><idno type="ISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-07-05">2005-07-05</date><biblScope unit="volume">136B</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="72">72</biblScope><biblScope unit="page" to="74">74</biblScope></imprint><idno type="ISSN">1552-4841</idno></series><idno type="istex">8597E6EA47C2A351548E63379CB0327F70791D8F</idno><idno type="DOI">10.1002/ajmg.b.30196</idno><idno type="ArticleID">AJMG30196</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-4841</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>apolipoprotein E</term><term>genetics</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease. © 2005 Wiley‐Liss, Inc.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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