Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease
Identifieur interne : 002C87 ( Main/Curation ); précédent : 002C86; suivant : 002C88Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease
Auteurs : Maria Martinez [France] ; Alexis Brice [France] ; Jenny R. Vaughan [Royaume-Uni] ; Alexander Zimprich [Allemagne] ; Monique M. B. Breteler [Pays-Bas] ; Giuseppe Meco [Italie] ; Alessandro Filla [Italie] ; Matthew J. Farrer [États-Unis] ; Christine Bétard [France] ; Andrew Singleton [États-Unis] ; John Hardy [États-Unis] ; Giuseppe De Michele [Italie] ; Vincenzo Bonifati [Italie] ; Ben A. Oostra [Pays-Bas] ; Thomas Gasser [Allemagne] ; Nick W. Wood [Royaume-Uni] ; Alexandra Dürr [France]Source :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2005-07-05.
English descriptors
- KwdEn :
- Alleles, Apolipoprotein E4, Apolipoproteins E (genetics), Chromosomes, Human, Pair 19 (genetics), Family Health, Gene Frequency, Genetic Linkage, Genotype, Humans, Linkage Disequilibrium, Lod Score, Microsatellite Repeats, Parkinson Disease (genetics), Parkinson's disease, Siblings, apolipoprotein E, genetics.
- MESH :
- chemical , genetics : Apolipoproteins E.
- chemical : Apolipoprotein E4.
- genetics : Chromosomes, Human, Pair 19, Parkinson Disease.
- Alleles, Family Health, Gene Frequency, Genetic Linkage, Genotype, Humans, Linkage Disequilibrium, Lod Score, Microsatellite Repeats, Siblings.
Abstract
Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease. © 2005 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ajmg.b.30196
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<term>Chromosomes, Human, Pair 19 (genetics)</term>
<term>Family Health</term>
<term>Gene Frequency</term>
<term>Genetic Linkage</term>
<term>Genotype</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>Lod Score</term>
<term>Microsatellite Repeats</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson's disease</term>
<term>Siblings</term>
<term>apolipoprotein E</term>
<term>genetics</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term>
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<term>Parkinson Disease</term>
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<term>Family Health</term>
<term>Gene Frequency</term>
<term>Genetic Linkage</term>
<term>Genotype</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>Lod Score</term>
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<front><div type="abstract" xml:lang="en">Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease. © 2005 Wiley‐Liss, Inc.</div>
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