Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.
Identifieur interne : 000528 ( Ncbi/Checkpoint ); précédent : 000527; suivant : 000529Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.
Auteurs : Maria Martinez [France] ; Alexis Brice ; Jenny R. Vaughan ; Alexander Zimprich ; Monique M B. Breteler ; Giuseppe Meco ; Alessandro Filla ; Matthew J. Farrer ; Christine Bétard ; Andrew Singleton ; John Hardy ; Giuseppe De Michele ; Vincenzo Bonifati ; Ben A. Oostra ; Thomas Gasser ; Nick W. Wood ; Alexandra DürrSource :
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics [ 1552-4841 ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Apolipoproteins E.
- chemical : Apolipoprotein E4.
- genetics : Chromosomes, Human, Pair 19, Parkinson Disease.
- Alleles, Family Health, Gene Frequency, Genetic Linkage, Genotype, Humans, Linkage Disequilibrium, Lod Score, Microsatellite Repeats, Siblings.
Abstract
Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.
DOI: 10.1002/ajmg.b.30196
PubMed: 15924299
Affiliations:
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pubmed:15924299Le document en format XML
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<author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM EMI00-06, Evry, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.</title>
<author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM EMI00-06, Evry</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
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<author><name sortKey="Vaughan, Jenny R" sort="Vaughan, Jenny R" uniqKey="Vaughan J" first="Jenny R" last="Vaughan">Jenny R. Vaughan</name>
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<author><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name>
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<author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M B" last="Breteler">Monique M B. Breteler</name>
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<author><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name>
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<author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name>
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<author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name>
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<author><name sortKey="Betard, Christine" sort="Betard, Christine" uniqKey="Betard C" first="Christine" last="Bétard">Christine Bétard</name>
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<author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name>
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<author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
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<author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
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<author><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name>
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<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A" last="Oostra">Ben A. Oostra</name>
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<author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
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<author><name sortKey="Wood, Nick W" sort="Wood, Nick W" uniqKey="Wood N" first="Nick W" last="Wood">Nick W. Wood</name>
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<author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name>
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<series><title level="j">American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics</title>
<idno type="ISSN">1552-4841</idno>
<imprint><date when="2005" type="published">2005</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term>
<term>Apolipoprotein E4</term>
<term>Apolipoproteins E (genetics)</term>
<term>Chromosomes, Human, Pair 19 (genetics)</term>
<term>Family Health</term>
<term>Gene Frequency</term>
<term>Genetic Linkage</term>
<term>Genotype</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>Lod Score</term>
<term>Microsatellite Repeats</term>
<term>Parkinson Disease (genetics)</term>
<term>Siblings</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Apolipoprotein E4</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 19</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Alleles</term>
<term>Family Health</term>
<term>Gene Frequency</term>
<term>Genetic Linkage</term>
<term>Genotype</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>Lod Score</term>
<term>Microsatellite Repeats</term>
<term>Siblings</term>
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<front><div type="abstract" xml:lang="en">Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.</div>
</front>
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<tree><noCountry><name sortKey="Betard, Christine" sort="Betard, Christine" uniqKey="Betard C" first="Christine" last="Bétard">Christine Bétard</name>
<name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name>
<name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M B" last="Breteler">Monique M B. Breteler</name>
<name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
<name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
<name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name>
<name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name>
<name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name>
<name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
<name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name>
<name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A" last="Oostra">Ben A. Oostra</name>
<name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name>
<name sortKey="Vaughan, Jenny R" sort="Vaughan, Jenny R" uniqKey="Vaughan J" first="Jenny R" last="Vaughan">Jenny R. Vaughan</name>
<name sortKey="Wood, Nick W" sort="Wood, Nick W" uniqKey="Wood N" first="Nick W" last="Wood">Nick W. Wood</name>
<name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name>
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