Pathological synchronization in Parkinson's disease : networks, models and treatments
Identifieur interne : 002805 ( Main/Exploration ); précédent : 002804; suivant : 002806Pathological synchronization in Parkinson's disease : networks, models and treatments
Auteurs : Constance Hammond [France] ; Hagai Bergman [Israël] ; Peter Brown [Royaume-Uni]Source :
- Trends in neurosciences : (Regular edition) [ 0166-2236 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Animal model, Animals, Basal Ganglia (physiopathology), Basal ganglion, Biological Clocks (physiology), Body movement, Corpus striatum, Deep brain stimulation, Disease Models, Animal, Human, Humans, Models, Neurological, Nerve Net (physiopathology), Oscillation, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson disease, Preparation, Review, Strategy, Suppression, Synchronization, Treatment, Voluntary movement.
- MESH :
- pathology : Parkinson Disease.
- physiology : Biological Clocks.
- physiopathology : Basal Ganglia, Nerve Net, Parkinson Disease.
- therapy : Parkinson Disease.
- Animals, Disease Models, Animal, Humans, Models, Neurological.
Abstract
Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/ TINS symposium (http://inmednet.com/).
Url:
Affiliations:
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Le document en format XML
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treatments</title><author><name sortKey="Hammond, Constance" sort="Hammond, Constance" uniqKey="Hammond C" first="Constance" last="Hammond">Constance Hammond</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2</s1><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Université Bordeaux 2</wicri:noRegion><wicri:noRegion>Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2</wicri:noRegion></affiliation></author><author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Physiology, The Eric Roland Center for Neurodegenerative Diseases and the Center for Neural Computation, The Hebrew University -Hadassah Medical School</s1><s2>Jerusalem, 91120</s2><s3>ISR</s3><sZ>2 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Jerusalem, 91120</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology</s1><s2>London, WC1N 3BG</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London, WC1N 3BG</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Trends in neurosciences : (Regular edition)</title><title level="j" type="abbreviated">Trends neurosci. : (Regul. ed.)</title><idno type="ISSN">0166-2236</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Trends in neurosciences : (Regular edition)</title><title 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xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Biological Clocks</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Nerve Net</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Models, Neurological</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Synchronisation</term><term>Modèle animal</term><term>Traitement</term><term>Corps strié</term><term>Mouvement volontaire</term><term>Mouvement corporel</term><term>Préparation</term><term>Noyau gris central</term><term>Parkinson maladie</term><term>Suppression</term><term>Stratégie</term><term>Article synthèse</term><term>Oscillation</term><term>Homme</term><term>Stimulation cérébrale profonde</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/ TINS symposium (http://inmednet.com/).</div></front></TEI><affiliations><list><country><li>France</li><li>Israël</li><li>Royaume-Uni</li></country></list><tree><country name="France"><noRegion><name sortKey="Hammond, Constance" sort="Hammond, Constance" uniqKey="Hammond C" first="Constance" last="Hammond">Constance Hammond</name></noRegion></country><country name="Israël"><noRegion><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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