ParkinsonFranceV1, Main, Merge, bibRecord, 002856

Pathological synchronization in Parkinson's disease: networks, models and treatments.

Identifieur interne : 002856 ( Main/Merge ); précédent : 002855; suivant : 002857

Pathological synchronization in Parkinson's disease: networks, models and treatments.

Auteurs : Constance Hammond [France] ; Hagai Bergman ; Peter Brown

Source :

Trends in neurosciences [ 0166-2236 ] ; 2007.

RBID : pubmed:17532060

English descriptors

KwdEn :
- Animals, Basal Ganglia (physiopathology), Biological Clocks (physiology), Disease Models, Animal, Humans, Models, Neurological, Nerve Net (physiopathology), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy).
MESH :
- pathology : Parkinson Disease.
- physiology : Biological Clocks.
- physiopathology : Basal Ganglia, Nerve Net, Parkinson Disease.
- therapy : Parkinson Disease.
- Animals, Disease Models, Animal, Humans, Models, Neurological.

Abstract

Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com/).

Url:

http://www.hal.inserm.fr/inserm-00483864

DOI: 10.1016/j.tins.2007.05.004
PubMed: 17532060

Links to Exploration step

pubmed:17532060

Le document en format XML

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<front><div type="abstract" xml:lang="en">Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com/).</div>
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   |texte=   Pathological synchronization in Parkinson's disease: networks, models and treatments.
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La maladie de Parkinson en France (serveur d'exploration)

Pathological synchronization in Parkinson's disease: networks, models and treatments.

Pathological synchronization in Parkinson's disease: networks, models and treatments.

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	La maladie de Parkinson en France (serveur d'exploration)
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