Pathological synchronization in Parkinson's disease: networks, models and treatments.
Identifieur interne : 002856 ( Main/Merge ); précédent : 002855; suivant : 002857Pathological synchronization in Parkinson's disease: networks, models and treatments.
Auteurs : Constance Hammond [France] ; Hagai Bergman ; Peter BrownSource :
- Trends in neurosciences [ 0166-2236 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- pathology : Parkinson Disease.
- physiology : Biological Clocks.
- physiopathology : Basal Ganglia, Nerve Net, Parkinson Disease.
- therapy : Parkinson Disease.
- Animals, Disease Models, Animal, Humans, Models, Neurological.
Abstract
Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com/).
Url:
DOI: 10.1016/j.tins.2007.05.004
PubMed: 17532060
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000D76
- to stream PubMed, to step Curation: 000D36
- to stream PubMed, to step Checkpoint: 000D36
- to stream Ncbi, to step Merge: 000732
- to stream Ncbi, to step Curation: 000732
- to stream Ncbi, to step Checkpoint: 000732
- to stream Hal, to step Corpus: 000869
- to stream Hal, to step Curation: 000869
- to stream Hal, to step Checkpoint: 000967
Links to Exploration step
pubmed:17532060Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pathological synchronization in Parkinson's disease: networks, models and treatments.</title>
<author><name sortKey="Hammond, Constance" sort="Hammond, Constance" uniqKey="Hammond C" first="Constance" last="Hammond">Constance Hammond</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2</wicri:regionArea>
<wicri:noRegion>Université Bordeaux 2</wicri:noRegion>
<wicri:noRegion>Université Bordeaux 2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name>
</author>
<author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="RBID">pubmed:17532060</idno>
<idno type="pmid">17532060</idno>
<idno type="doi">10.1016/j.tins.2007.05.004</idno>
<idno type="wicri:Area/PubMed/Corpus">000D76</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D76</idno>
<idno type="wicri:Area/PubMed/Curation">000D36</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D36</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000D36</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D36</idno>
<idno type="wicri:Area/Ncbi/Merge">000732</idno>
<idno type="wicri:Area/Ncbi/Curation">000732</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000732</idno>
<idno type="wicri:doubleKey">0166-2236:2007:Hammond C:pathological:synchronization:in</idno>
<idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:inserm-00483864</idno>
<idno type="url">http://www.hal.inserm.fr/inserm-00483864</idno>
<idno type="wicri:Area/Hal/Corpus">000869</idno>
<idno type="wicri:Area/Hal/Curation">000869</idno>
<idno type="wicri:Area/Hal/Checkpoint">000967</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000967</idno>
<idno type="wicri:doubleKey">0166-2236:2007:Hammond C:pathological:synchronization:in</idno>
<idno type="wicri:Area/Main/Merge">002856</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Pathological synchronization in Parkinson's disease: networks, models and treatments.</title>
<author><name sortKey="Hammond, Constance" sort="Hammond, Constance" uniqKey="Hammond C" first="Constance" last="Hammond">Constance Hammond</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2</wicri:regionArea>
<wicri:noRegion>Université Bordeaux 2</wicri:noRegion>
<wicri:noRegion>Université Bordeaux 2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name>
</author>
<author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name>
</author>
</analytic>
<series><title level="j">Trends in neurosciences</title>
<idno type="ISSN">0166-2236</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Basal Ganglia (physiopathology)</term>
<term>Biological Clocks (physiology)</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Models, Neurological</term>
<term>Nerve Net (physiopathology)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Biological Clocks</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Nerve Net</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Models, Neurological</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com/).</div>
</front>
</TEI>
<double doi="10.1016/j.tins.2007.05.004"><HAL><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pathological synchronization in Parkinson's disease: networks, models and treatments.</title>
<author><name sortKey="Hammond, Constance" sort="Hammond, Constance" uniqKey="Hammond C" first="Constance" last="Hammond">Constance Hammond</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2797" status="OLD"> <orgName>Epilepsie et ischémie cérébrale</orgName>
<desc> <address> <addrLine>Inst Neurobiologie de La Mediterranee 163, Avenue de Luminy 13273 MARSEILLE CEDEX 09</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inmed.univ-mrs.fr/</ref>
</desc>
<listRelation> <relation active="#struct-5033" type="direct"></relation>
<relation name="U29" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-5033" type="direct"><org type="institution" xml:id="struct-5033" status="OLD"><idno type="IdRef">026402882</idno>
<orgName>Université de la Méditerranée - Aix-Marseille 2</orgName>
<date type="start">1969</date>
<date type="end">2011</date>
<desc><address><addrLine>58, boulevard Charles Livon - 13284 Marseille cedex 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univmed.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U29" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-116076" status="INCOMING"> <orgName>Department of Physiology</orgName>
<desc> <address> <addrLine>Center for Neural Computation – Hadassah Medical School, Jerusalem, 91120</addrLine>
<country key="IL"></country>
</address>
</desc>
<listRelation> <relation active="#struct-305630" type="direct"></relation>
<relation active="#struct-328098" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-305630" type="direct"><org type="institution" xml:id="struct-305630" status="INCOMING"> <orgName>The Hebrew University</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-328098" type="direct"><org type="institution" xml:id="struct-328098" status="INCOMING"> <orgName>The Eric Roland Center for Neurodegenerative Diseases</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Israël</country>
</affiliation>
</author>
<author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-116077" status="INCOMING"> <orgName>Sobell Department of Motor Neuroscience and Movement Disorders</orgName>
<desc> <address> <addrLine>London, WC1N 3BG</addrLine>
<country key="GB"></country>
</address>
</desc>
<listRelation> <relation active="#struct-310129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-310129" type="direct"><org type="institution" xml:id="struct-310129" status="INCOMING"> <orgName>Institute of Neurology</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Royaume-Uni</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:inserm-00483864</idno>
<idno type="halId">inserm-00483864</idno>
<idno type="halUri">http://www.hal.inserm.fr/inserm-00483864</idno>
<idno type="url">http://www.hal.inserm.fr/inserm-00483864</idno>
<idno type="doi">10.1016/j.tins.2007.05.004</idno>
<date when="2007-07">2007-07</date>
<idno type="wicri:Area/Hal/Corpus">000869</idno>
<idno type="wicri:Area/Hal/Curation">000869</idno>
<idno type="wicri:Area/Hal/Checkpoint">000967</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000967</idno>
<idno type="wicri:doubleKey">0166-2236:2007:Hammond C:pathological:synchronization:in</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Pathological synchronization in Parkinson's disease: networks, models and treatments.</title>
<author><name sortKey="Hammond, Constance" sort="Hammond, Constance" uniqKey="Hammond C" first="Constance" last="Hammond">Constance Hammond</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2797" status="OLD"> <orgName>Epilepsie et ischémie cérébrale</orgName>
<desc> <address> <addrLine>Inst Neurobiologie de La Mediterranee 163, Avenue de Luminy 13273 MARSEILLE CEDEX 09</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inmed.univ-mrs.fr/</ref>
</desc>
<listRelation> <relation active="#struct-5033" type="direct"></relation>
<relation name="U29" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-5033" type="direct"><org type="institution" xml:id="struct-5033" status="OLD"><idno type="IdRef">026402882</idno>
<orgName>Université de la Méditerranée - Aix-Marseille 2</orgName>
<date type="start">1969</date>
<date type="end">2011</date>
<desc><address><addrLine>58, boulevard Charles Livon - 13284 Marseille cedex 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univmed.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="U29" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-116076" status="INCOMING"> <orgName>Department of Physiology</orgName>
<desc> <address> <addrLine>Center for Neural Computation – Hadassah Medical School, Jerusalem, 91120</addrLine>
<country key="IL"></country>
</address>
</desc>
<listRelation> <relation active="#struct-305630" type="direct"></relation>
<relation active="#struct-328098" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-305630" type="direct"><org type="institution" xml:id="struct-305630" status="INCOMING"> <orgName>The Hebrew University</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-328098" type="direct"><org type="institution" xml:id="struct-328098" status="INCOMING"> <orgName>The Eric Roland Center for Neurodegenerative Diseases</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Israël</country>
</affiliation>
</author>
<author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-116077" status="INCOMING"> <orgName>Sobell Department of Motor Neuroscience and Movement Disorders</orgName>
<desc> <address> <addrLine>London, WC1N 3BG</addrLine>
<country key="GB"></country>
</address>
</desc>
<listRelation> <relation active="#struct-310129" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-310129" type="direct"><org type="institution" xml:id="struct-310129" status="INCOMING"> <orgName>Institute of Neurology</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Royaume-Uni</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.tins.2007.05.004</idno>
<series><title level="j">Trends in Neurosciences</title>
<idno type="ISSN">0166-2236</idno>
<imprint><date type="datePub">2007-07</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com/).</div>
</front>
</TEI>
</HAL>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pathological synchronization in Parkinson's disease: networks, models and treatments.</title>
<author><name sortKey="Hammond, Constance" sort="Hammond, Constance" uniqKey="Hammond C" first="Constance" last="Hammond">Constance Hammond</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2</wicri:regionArea>
<wicri:noRegion>Université Bordeaux 2</wicri:noRegion>
<wicri:noRegion>Université Bordeaux 2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name>
</author>
<author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="RBID">pubmed:17532060</idno>
<idno type="pmid">17532060</idno>
<idno type="doi">10.1016/j.tins.2007.05.004</idno>
<idno type="wicri:Area/PubMed/Corpus">000D76</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D76</idno>
<idno type="wicri:Area/PubMed/Curation">000D36</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D36</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000D36</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D36</idno>
<idno type="wicri:Area/Ncbi/Merge">000732</idno>
<idno type="wicri:Area/Ncbi/Curation">000732</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000732</idno>
<idno type="wicri:doubleKey">0166-2236:2007:Hammond C:pathological:synchronization:in</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Pathological synchronization in Parkinson's disease: networks, models and treatments.</title>
<author><name sortKey="Hammond, Constance" sort="Hammond, Constance" uniqKey="Hammond C" first="Constance" last="Hammond">Constance Hammond</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2</wicri:regionArea>
<wicri:noRegion>Université Bordeaux 2</wicri:noRegion>
<wicri:noRegion>Université Bordeaux 2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name>
</author>
<author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name>
</author>
</analytic>
<series><title level="j">Trends in neurosciences</title>
<idno type="ISSN">0166-2236</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Basal Ganglia (physiopathology)</term>
<term>Biological Clocks (physiology)</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Models, Neurological</term>
<term>Nerve Net (physiopathology)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Biological Clocks</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Nerve Net</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Models, Neurological</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com/).</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002856 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 002856 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Merge |type= RBID |clé= pubmed:17532060 |texte= Pathological synchronization in Parkinson's disease: networks, models and treatments. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:17532060" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |