ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 000A12

Pathological synchronization in Parkinson's disease : networks, models and treatments

Identifieur interne : 000A12 ( PascalFrancis/Corpus ); précédent : 000A11; suivant : 000A13

Pathological synchronization in Parkinson's disease : networks, models and treatments

Auteurs : Constance Hammond ; Hagai Bergman ; Peter Brown

Source :

Trends in neurosciences : (Regular edition) [ 0166-2236 ] ; 2007.

RBID : Pascal:07-0404923

Descripteurs français

Pascal (Inist)
- Synchronisation, Modèle animal, Traitement, Corps strié, Mouvement volontaire, Mouvement corporel, Préparation, Noyau gris central, Parkinson maladie, Suppression, Stratégie, Article synthèse, Oscillation, Homme, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Animal model, Basal ganglion, Body movement, Corpus striatum, Deep brain stimulation, Human, Oscillation, Parkinson disease, Preparation, Review, Strategy, Suppression, Synchronization, Treatment, Voluntary movement.

Abstract

Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/ TINS symposium (http://inmednet.com/).

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 07-0404923 INIST
ET :	Pathological synchronization in Parkinson's disease : networks, models and treatments
AU :	HAMMOND (Constance); BERGMAN (Hagai); BROWN (Peter); BEN-ARI (Yehezkel)
AF :	Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2/France (1 aut.); Department of Physiology, The Eric Roland Center for Neurodegenerative Diseases and the Center for Neural Computation, The Hebrew University -Hadassah Medical School/Jerusalem, 91120/Israël (2 aut.); Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology/London, WC1N 3BG/Royaume-Uni (3 aut.); INSERM U29-INMED, Parc Scientifique de Luminy, BP 13/13273 Marseille/France (1 aut.)
DT :	Publication en série; Congrès; Niveau analytique
SO :	Trends in neurosciences : (Regular edition); ISSN 0166-2236; Royaume-Uni; Da. 2007; Vol. 30; No. 7; Pp. 357-364; Bibl. 72 ref.
LA :	Anglais
EA :	Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/ TINS symposium (http://inmednet.com/).
CC :	002B17G; 002A25E
FD :	Synchronisation; Modèle animal; Traitement; Corps strié; Mouvement volontaire; Mouvement corporel; Préparation; Noyau gris central; Parkinson maladie; Suppression; Stratégie; Article synthèse; Oscillation; Homme; Stimulation cérébrale profonde
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux pathologie; Système nerveux central
ED :	Synchronization; Animal model; Treatment; Corpus striatum; Voluntary movement; Body movement; Preparation; Basal ganglion; Parkinson disease; Suppression; Strategy; Review; Oscillation; Human; Deep brain stimulation
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases; Central nervous system
SD :	Sincronización; Modelo animal; Tratamiento; Cuerpo estriado; Movimiento voluntario; Movimiento corporal; Preparación; Núcleo basal; Parkinson enfermedad; Supresión; Estrategia; Artículo síntesis; Oscilación; Hombre
LO :	INIST-18018B.354000162978560070
ID :	07-0404923

Links to Exploration step

Pascal:07-0404923

Le document en format XML

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<front><div type="abstract" xml:lang="en">Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/ TINS symposium (http://inmednet.com/).</div>
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<fC03 i1="03" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Corps strié</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Corpus striatum</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Cuerpo estriado</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Mouvement volontaire</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Voluntary movement</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Movimiento voluntario</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Mouvement corporel</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Body movement</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Movimiento corporal</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Préparation</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Preparation</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Preparación</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Noyau gris central</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Basal ganglion</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Núcleo basal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Suppression</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Suppression</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Supresión</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Stratégie</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Strategy</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Estrategia</s0>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Article synthèse</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Review</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Artículo síntesis</s0>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Oscillation</s0>
<s5>14</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Oscillation</s0>
<s5>14</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Oscilación</s0>
<s5>14</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Homme</s0>
<s5>54</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Human</s0>
<s5>54</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Hombre</s0>
<s5>54</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Stimulation cérébrale profonde</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Deep brain stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>22</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>22</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>22</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>23</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>24</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>25</s5>
</fC07>
<fN21><s1>260</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
<pR><fA30 i1="01" i2="1" l="ENG"><s1>INMED/TINS Conference</s1>
<s2>5</s2>
<s3>La Ciotat FRA</s3>
<s4>2006-09-09</s4>
</fA30>
</pR>
</standard>
<server><NO>PASCAL 07-0404923 INIST</NO>
<ET>Pathological synchronization in Parkinson's disease : networks, models and treatments</ET>
<AU>HAMMOND (Constance); BERGMAN (Hagai); BROWN (Peter); BEN-ARI (Yehezkel)</AU>
<AF>Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2/France (1 aut.); Department of Physiology, The Eric Roland Center for Neurodegenerative Diseases and the Center for Neural Computation, The Hebrew University -Hadassah Medical School/Jerusalem, 91120/Israël (2 aut.); Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology/London, WC1N 3BG/Royaume-Uni (3 aut.); INSERM U29-INMED, Parc Scientifique de Luminy, BP 13/13273 Marseille/France (1 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Trends in neurosciences : (Regular edition); ISSN 0166-2236; Royaume-Uni; Da. 2007; Vol. 30; No. 7; Pp. 357-364; Bibl. 72 ref.</SO>
<LA>Anglais</LA>
<EA>Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/ TINS symposium (http://inmednet.com/).</EA>
<CC>002B17G; 002A25E</CC>
<FD>Synchronisation; Modèle animal; Traitement; Corps strié; Mouvement volontaire; Mouvement corporel; Préparation; Noyau gris central; Parkinson maladie; Suppression; Stratégie; Article synthèse; Oscillation; Homme; Stimulation cérébrale profonde</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux pathologie; Système nerveux central</FG>
<ED>Synchronization; Animal model; Treatment; Corpus striatum; Voluntary movement; Body movement; Preparation; Basal ganglion; Parkinson disease; Suppression; Strategy; Review; Oscillation; Human; Deep brain stimulation</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases; Central nervous system</EG>
<SD>Sincronización; Modelo animal; Tratamiento; Cuerpo estriado; Movimiento voluntario; Movimiento corporal; Preparación; Núcleo basal; Parkinson enfermedad; Supresión; Estrategia; Artículo síntesis; Oscilación; Hombre</SD>
<LO>INIST-18018B.354000162978560070</LO>
<ID>07-0404923</ID>
</server>
</inist>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Pathological synchronization in Parkinson's disease : networks, models and treatments

Pathological synchronization in Parkinson's disease : networks, models and treatments

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