Pathological synchronization in Parkinson's disease : networks, models and treatments
Identifieur interne : 000A12 ( PascalFrancis/Corpus ); précédent : 000A11; suivant : 000A13Pathological synchronization in Parkinson's disease : networks, models and treatments
Auteurs : Constance Hammond ; Hagai Bergman ; Peter BrownSource :
- Trends in neurosciences : (Regular edition) [ 0166-2236 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/ TINS symposium (http://inmednet.com/).
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 07-0404923 INIST |
---|---|
ET : | Pathological synchronization in Parkinson's disease : networks, models and treatments |
AU : | HAMMOND (Constance); BERGMAN (Hagai); BROWN (Peter); BEN-ARI (Yehezkel) |
AF : | Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2/France (1 aut.); Department of Physiology, The Eric Roland Center for Neurodegenerative Diseases and the Center for Neural Computation, The Hebrew University -Hadassah Medical School/Jerusalem, 91120/Israël (2 aut.); Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology/London, WC1N 3BG/Royaume-Uni (3 aut.); INSERM U29-INMED, Parc Scientifique de Luminy, BP 13/13273 Marseille/France (1 aut.) |
DT : | Publication en série; Congrès; Niveau analytique |
SO : | Trends in neurosciences : (Regular edition); ISSN 0166-2236; Royaume-Uni; Da. 2007; Vol. 30; No. 7; Pp. 357-364; Bibl. 72 ref. |
LA : | Anglais |
EA : | Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/ TINS symposium (http://inmednet.com/). |
CC : | 002B17G; 002A25E |
FD : | Synchronisation; Modèle animal; Traitement; Corps strié; Mouvement volontaire; Mouvement corporel; Préparation; Noyau gris central; Parkinson maladie; Suppression; Stratégie; Article synthèse; Oscillation; Homme; Stimulation cérébrale profonde |
FG : | Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux pathologie; Système nerveux central |
ED : | Synchronization; Animal model; Treatment; Corpus striatum; Voluntary movement; Body movement; Preparation; Basal ganglion; Parkinson disease; Suppression; Strategy; Review; Oscillation; Human; Deep brain stimulation |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases; Central nervous system |
SD : | Sincronización; Modelo animal; Tratamiento; Cuerpo estriado; Movimiento voluntario; Movimiento corporal; Preparación; Núcleo basal; Parkinson enfermedad; Supresión; Estrategia; Artículo síntesis; Oscilación; Hombre |
LO : | INIST-18018B.354000162978560070 |
ID : | 07-0404923 |
Links to Exploration step
Pascal:07-0404923Le document en format XML
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<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>23</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>24</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>25</s5>
</fC07>
<fN21><s1>260</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
<pR><fA30 i1="01" i2="1" l="ENG"><s1>INMED/TINS Conference</s1>
<s2>5</s2>
<s3>La Ciotat FRA</s3>
<s4>2006-09-09</s4>
</fA30>
</pR>
</standard>
<server><NO>PASCAL 07-0404923 INIST</NO>
<ET>Pathological synchronization in Parkinson's disease : networks, models and treatments</ET>
<AU>HAMMOND (Constance); BERGMAN (Hagai); BROWN (Peter); BEN-ARI (Yehezkel)</AU>
<AF>Institut de Neurobiologie de la Méditerranée, U29 Inserm, Université Aix-Marseille II and UMR CNRS 5543, Université Bordeaux 2/France (1 aut.); Department of Physiology, The Eric Roland Center for Neurodegenerative Diseases and the Center for Neural Computation, The Hebrew University -Hadassah Medical School/Jerusalem, 91120/Israël (2 aut.); Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology/London, WC1N 3BG/Royaume-Uni (3 aut.); INSERM U29-INMED, Parc Scientifique de Luminy, BP 13/13273 Marseille/France (1 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Trends in neurosciences : (Regular edition); ISSN 0166-2236; Royaume-Uni; Da. 2007; Vol. 30; No. 7; Pp. 357-364; Bibl. 72 ref.</SO>
<LA>Anglais</LA>
<EA>Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/ TINS symposium (http://inmednet.com/).</EA>
<CC>002B17G; 002A25E</CC>
<FD>Synchronisation; Modèle animal; Traitement; Corps strié; Mouvement volontaire; Mouvement corporel; Préparation; Noyau gris central; Parkinson maladie; Suppression; Stratégie; Article synthèse; Oscillation; Homme; Stimulation cérébrale profonde</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux pathologie; Système nerveux central</FG>
<ED>Synchronization; Animal model; Treatment; Corpus striatum; Voluntary movement; Body movement; Preparation; Basal ganglion; Parkinson disease; Suppression; Strategy; Review; Oscillation; Human; Deep brain stimulation</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases; Central nervous system</EG>
<SD>Sincronización; Modelo animal; Tratamiento; Cuerpo estriado; Movimiento voluntario; Movimiento corporal; Preparación; Núcleo basal; Parkinson enfermedad; Supresión; Estrategia; Artículo síntesis; Oscilación; Hombre</SD>
<LO>INIST-18018B.354000162978560070</LO>
<ID>07-0404923</ID>
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