ParkinsonFranceV1, PascalFrancis, Checkpoint, bibRecord, 000866

Pathological synchronization in Parkinson's disease : networks, models and treatments

Identifieur interne : 000866 ( PascalFrancis/Checkpoint ); précédent : 000865; suivant : 000867

Pathological synchronization in Parkinson's disease : networks, models and treatments

Auteurs : Constance Hammond [France] ; Hagai Bergman [Israël] ; Peter Brown [Royaume-Uni]

Source :

Trends in neurosciences : (Regular edition) [ 0166-2236 ] ; 2007.

RBID : Pascal:07-0404923

Descripteurs français

Pascal (Inist)
- Synchronisation, Modèle animal, Traitement, Corps strié, Mouvement volontaire, Mouvement corporel, Préparation, Noyau gris central, Parkinson maladie, Suppression, Stratégie, Article synthèse, Oscillation, Homme, Stimulation cérébrale profonde.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Animal model, Basal ganglion, Body movement, Corpus striatum, Deep brain stimulation, Human, Oscillation, Parkinson disease, Preparation, Review, Strategy, Suppression, Synchronization, Treatment, Voluntary movement.

Abstract

Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/ TINS symposium (http://inmednet.com/).

Affiliations:

France, Israël, Royaume-Uni

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Le document en format XML

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EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PascalFrancis/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000866 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 000866 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    PascalFrancis
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Pascal:07-0404923
   |texte=   Pathological synchronization in Parkinson's disease : networks, models and treatments
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Pathological synchronization in Parkinson's disease : networks, models and treatments

Pathological synchronization in Parkinson's disease : networks, models and treatments

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English descriptors

Abstract

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Le document en format XML

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Pour mettre un lien sur cette page dans le réseau Wicri