Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system
Identifieur interne : 003023 ( Main/Exploration ); précédent : 003022; suivant : 003024Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system
Auteurs : Juan E. Ferrario [Argentine] ; Irene R. E. Taravini [Argentine] ; Sophie Mourlevat [France] ; Andrea Stefano [Argentine] ; Marina A. Delfino [Argentine] ; Rita Raisman-Vozari [France] ; M. Gustavo Murer [Argentine] ; Merle Ruberg [France] ; Oscar Gershanik [Argentine]Source :
- Journal of neurochemistry [ 0022-3042 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Levodopa, the major treatment for patients with Parkinson's disease, has been shown to induce a variety of compensatory effects, including facilitation of sprouting by dopaminergic neurons, in experimental animals with lesions leading to denervation of the striatum. To better understand the cellular and molecular environment where most of these compensatory changes take place, in particular elements that might contribute to the recovery of dopaminergic innervation, we have constructed a differential expression library enriched in transcripts from the striata of rats with lesions of the medial forebrain bundle treated with levodopa for 6 months. We have used this library to screen an expression array of rat genes representing the major cell functions, and have identified several that are involved in neurotrophic mechanisms and plasticity. We have confirmed the differential expression of selected transcripts by non-radioactive in situ hybridization, and report that the growth factor pleiotrophin, myelin basic protein and calmodulin are overexpressed in the denervated striatum of levodopa-treated rats.
Affiliations:
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Antiparkinson agent</term>
<term>Basic protein</term>
<term>Calmodulin</term>
<term>Chronic</term>
<term>Corpus striatum</term>
<term>Gene expression</term>
<term>Lesion</term>
<term>Levodopa</term>
<term>Myelin</term>
<term>Nigrostriatal pathway</term>
<term>Parkinson disease</term>
<term>Plasticity</term>
<term>Rat</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Expression génique</term>
<term>Chronique</term>
<term>Lévodopa</term>
<term>Corps strié</term>
<term>Lésion</term>
<term>Voie nigrostriatale</term>
<term>Calmoduline</term>
<term>Myéline</term>
<term>Parkinson maladie</term>
<term>Protéine basique</term>
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<front><div type="abstract" xml:lang="en">Levodopa, the major treatment for patients with Parkinson's disease, has been shown to induce a variety of compensatory effects, including facilitation of sprouting by dopaminergic neurons, in experimental animals with lesions leading to denervation of the striatum. To better understand the cellular and molecular environment where most of these compensatory changes take place, in particular elements that might contribute to the recovery of dopaminergic innervation, we have constructed a differential expression library enriched in transcripts from the striata of rats with lesions of the medial forebrain bundle treated with levodopa for 6 months. We have used this library to screen an expression array of rat genes representing the major cell functions, and have identified several that are involved in neurotrophic mechanisms and plasticity. We have confirmed the differential expression of selected transcripts by non-radioactive in situ hybridization, and report that the growth factor pleiotrophin, myelin basic protein and calmodulin are overexpressed in the denervated striatum of levodopa-treated rats.</div>
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