ParkinsonFranceV1, PascalFrancis, Curation, bibRecord, 000727

Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system

Identifieur interne : 000727 ( PascalFrancis/Curation ); précédent : 000726; suivant : 000728

Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system

Auteurs : Juan E. Ferrario [Argentine] ; Irene R. E. Taravini [Argentine] ; Sophie Mourlevat [France] ; Andrea Stefano [Argentine] ; Marina A. Delfino [Argentine] ; Rita Raisman-Vozari [France] ; M. Gustavo Murer [Argentine] ; Merle Ruberg [France] ; Oscar Gershanik [Argentine]

Source :

Journal of neurochemistry [ 0022-3042 ] ; 2004.

RBID : Pascal:05-0171106

Descripteurs français

Pascal (Inist)
- Expression génique, Chronique, Lévodopa, Corps strié, Lésion, Voie nigrostriatale, Calmoduline, Myéline, Parkinson maladie, Protéine basique, Plasticité, Antiparkinsonien, Animal, Rat.

English descriptors

KwdEn :
- Animal, Antiparkinson agent, Basic protein, Calmodulin, Chronic, Corpus striatum, Gene expression, Lesion, Levodopa, Myelin, Nigrostriatal pathway, Parkinson disease, Plasticity, Rat.

Abstract

Levodopa, the major treatment for patients with Parkinson's disease, has been shown to induce a variety of compensatory effects, including facilitation of sprouting by dopaminergic neurons, in experimental animals with lesions leading to denervation of the striatum. To better understand the cellular and molecular environment where most of these compensatory changes take place, in particular elements that might contribute to the recovery of dopaminergic innervation, we have constructed a differential expression library enriched in transcripts from the striata of rats with lesions of the medial forebrain bundle treated with levodopa for 6 months. We have used this library to screen an expression array of rat genes representing the major cell functions, and have identified several that are involved in neurotrophic mechanisms and plasticity. We have confirmed the differential expression of selected transcripts by non-radioactive in situ hybridization, and report that the growth factor pleiotrophin, myelin basic protein and calmodulin are overexpressed in the denervated striatum of levodopa-treated rats.

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C01	`01`		`ENG`	@0 Levodopa, the major treatment for patients with Parkinson's disease, has been shown to induce a variety of compensatory effects, including facilitation of sprouting by dopaminergic neurons, in experimental animals with lesions leading to denervation of the striatum. To better understand the cellular and molecular environment where most of these compensatory changes take place, in particular elements that might contribute to the recovery of dopaminergic innervation, we have constructed a differential expression library enriched in transcripts from the striata of rats with lesions of the medial forebrain bundle treated with levodopa for 6 months. We have used this library to screen an expression array of rat genes representing the major cell functions, and have identified several that are involved in neurotrophic mechanisms and plasticity. We have confirmed the differential expression of selected transcripts by non-radioactive in situ hybridization, and report that the growth factor pleiotrophin, myelin basic protein and calmodulin are overexpressed in the denervated striatum of levodopa-treated rats.
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Pascal:05-0171106

Le document en format XML

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<series><title level="j" type="main">Journal of neurochemistry</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Antiparkinson agent</term>
<term>Basic protein</term>
<term>Calmodulin</term>
<term>Chronic</term>
<term>Corpus striatum</term>
<term>Gene expression</term>
<term>Lesion</term>
<term>Levodopa</term>
<term>Myelin</term>
<term>Nigrostriatal pathway</term>
<term>Parkinson disease</term>
<term>Plasticity</term>
<term>Rat</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Expression génique</term>
<term>Chronique</term>
<term>Lévodopa</term>
<term>Corps strié</term>
<term>Lésion</term>
<term>Voie nigrostriatale</term>
<term>Calmoduline</term>
<term>Myéline</term>
<term>Parkinson maladie</term>
<term>Protéine basique</term>
<term>Plasticité</term>
<term>Antiparkinsonien</term>
<term>Animal</term>
<term>Rat</term>
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<front><div type="abstract" xml:lang="en">Levodopa, the major treatment for patients with Parkinson's disease, has been shown to induce a variety of compensatory effects, including facilitation of sprouting by dopaminergic neurons, in experimental animals with lesions leading to denervation of the striatum. To better understand the cellular and molecular environment where most of these compensatory changes take place, in particular elements that might contribute to the recovery of dopaminergic innervation, we have constructed a differential expression library enriched in transcripts from the striata of rats with lesions of the medial forebrain bundle treated with levodopa for 6 months. We have used this library to screen an expression array of rat genes representing the major cell functions, and have identified several that are involved in neurotrophic mechanisms and plasticity. We have confirmed the differential expression of selected transcripts by non-radioactive in situ hybridization, and report that the growth factor pleiotrophin, myelin basic protein and calmodulin are overexpressed in the denervated striatum of levodopa-treated rats.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-3042</s0>
</fA01>
<fA02 i1="01"><s0>JONRA9</s0>
</fA02>
<fA03 i2="1"><s0>J. neurochem.</s0>
</fA03>
<fA05><s2>90</s2>
</fA05>
<fA06><s2>6</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>FERRARIO (Juan E.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>TARAVINI (Irene R. E.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>MOURLEVAT (Sophie)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>STEFANO (Andrea)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>DELFINO (Marina A.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>RAISMAN-VOZARI (Rita)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>MURER (M. Gustavo)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>RUBERG (Merle)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>GERSHANIK (Oscar)</s1>
</fA11>
<fA14 i1="01"><s1>Instituto de Investigaciones Farmacológicas (ININFA), UBA-CONICET</s1>
<s2>Buenos Aires</s2>
<s3>ARG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires</s1>
<s2>Buenos Aires</s2>
<s3>ARG</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA20><s1>1348-1358</s1>
</fA20>
<fA21><s1>2004</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>4037</s2>
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<fA47 i1="01" i2="1"><s0>05-0171106</s0>
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<fA60><s1>P</s1>
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<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of neurochemistry</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Levodopa, the major treatment for patients with Parkinson's disease, has been shown to induce a variety of compensatory effects, including facilitation of sprouting by dopaminergic neurons, in experimental animals with lesions leading to denervation of the striatum. To better understand the cellular and molecular environment where most of these compensatory changes take place, in particular elements that might contribute to the recovery of dopaminergic innervation, we have constructed a differential expression library enriched in transcripts from the striata of rats with lesions of the medial forebrain bundle treated with levodopa for 6 months. We have used this library to screen an expression array of rat genes representing the major cell functions, and have identified several that are involved in neurotrophic mechanisms and plasticity. We have confirmed the differential expression of selected transcripts by non-radioactive in situ hybridization, and report that the growth factor pleiotrophin, myelin basic protein and calmodulin are overexpressed in the denervated striatum of levodopa-treated rats.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02B06</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17A01</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Expression génique</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Gene expression</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Expresión genética</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Chronique</s0>
<s5>02</s5>
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<fC03 i1="02" i2="X" l="ENG"><s0>Chronic</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Crónico</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Lévodopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Levodopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Levodopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Corps strié</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Corpus striatum</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Cuerpo estriado</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Lésion</s0>
<s5>05</s5>
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<fC03 i1="05" i2="X" l="ENG"><s0>Lesion</s0>
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<s5>05</s5>
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<fC03 i1="06" i2="X" l="FRE"><s0>Voie nigrostriatale</s0>
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<s5>06</s5>
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<fC03 i1="06" i2="X" l="SPA"><s0>Vía nigroestriatal</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Calmoduline</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Calmodulin</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Calmodulina</s0>
<s5>07</s5>
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<fC03 i1="08" i2="X" l="FRE"><s0>Myéline</s0>
<s5>08</s5>
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<fC03 i1="08" i2="X" l="ENG"><s0>Myelin</s0>
<s5>08</s5>
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<fC03 i1="08" i2="X" l="SPA"><s0>Mielina</s0>
<s5>08</s5>
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<fC03 i1="09" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>09</s5>
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<fC03 i1="09" i2="X" l="ENG"><s0>Parkinson disease</s0>
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</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>09</s5>
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<fC03 i1="10" i2="X" l="FRE"><s0>Protéine basique</s0>
<s5>10</s5>
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<fC03 i1="10" i2="X" l="ENG"><s0>Basic protein</s0>
<s5>10</s5>
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<fC03 i1="10" i2="X" l="SPA"><s0>Proteína básica</s0>
<s5>10</s5>
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<fC03 i1="11" i2="X" l="FRE"><s0>Plasticité</s0>
<s5>11</s5>
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<fC03 i1="11" i2="X" l="ENG"><s0>Plasticity</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Plasticidad</s0>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Antiparkinsonien</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Antiparkinson agent</s0>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Antiparkinsoniano</s0>
<s5>13</s5>
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<s5>54</s5>
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<s5>54</s5>
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<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>20</s5>
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<s5>20</s5>
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<s5>20</s5>
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<s5>21</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>23</s5>
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<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>24</s5>
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<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>24</s5>
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<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>24</s5>
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<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>25</s5>
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<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>25</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>26</s5>
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<fC07 i1="07" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>26</s5>
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<s5>26</s5>
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<fC07 i1="08" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
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<fC07 i1="08" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
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<fC07 i1="09" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
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<s2>NS</s2>
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<fC07 i1="09" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
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<s2>NS</s2>
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<s2>NS</s2>
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<fC07 i1="10" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>115</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system

Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system

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