Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system
Identifieur interne : 003453 ( Main/Merge ); précédent : 003452; suivant : 003454Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system
Auteurs : Juan E. Ferrario [Argentine] ; Irene R. E. Taravini [Argentine] ; Sophie Mourlevat [France] ; Andrea Stefano [Argentine] ; Marina A. Delfino [Argentine] ; Rita Raisman-Vozari [France] ; M. Gustavo Murer [Argentine] ; Merle Ruberg [France] ; Oscar Gershanik [Argentine]Source :
- Journal of neurochemistry [ 0022-3042 ] ; 2004.
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Abstract
Levodopa, the major treatment for patients with Parkinson's disease, has been shown to induce a variety of compensatory effects, including facilitation of sprouting by dopaminergic neurons, in experimental animals with lesions leading to denervation of the striatum. To better understand the cellular and molecular environment where most of these compensatory changes take place, in particular elements that might contribute to the recovery of dopaminergic innervation, we have constructed a differential expression library enriched in transcripts from the striata of rats with lesions of the medial forebrain bundle treated with levodopa for 6 months. We have used this library to screen an expression array of rat genes representing the major cell functions, and have identified several that are involved in neurotrophic mechanisms and plasticity. We have confirmed the differential expression of selected transcripts by non-radioactive in situ hybridization, and report that the growth factor pleiotrophin, myelin basic protein and calmodulin are overexpressed in the denervated striatum of levodopa-treated rats.
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Ferrario</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Instituto de Investigaciones Farmacológicas (ININFA), UBA-CONICET</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Argentine</country><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Taravini, Irene R E" sort="Taravini, Irene R E" uniqKey="Taravini I" first="Irene R. E." last="Taravini">Irene R. E. Taravini</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Instituto de Investigaciones Farmacológicas (ININFA), UBA-CONICET</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Argentine</country><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Mourlevat, Sophie" sort="Mourlevat, Sophie" uniqKey="Mourlevat S" first="Sophie" last="Mourlevat">Sophie Mourlevat</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Stefano, Andrea" sort="Stefano, Andrea" uniqKey="Stefano A" first="Andrea" last="Stefano">Andrea Stefano</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Instituto de Investigaciones Farmacológicas (ININFA), UBA-CONICET</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Argentine</country><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Delfino, Marina A" sort="Delfino, Marina A" uniqKey="Delfino M" first="Marina A." last="Delfino">Marina A. Delfino</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Instituto de Investigaciones Farmacológicas (ININFA), UBA-CONICET</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Argentine</country><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Murer, M Gustavo" sort="Murer, M Gustavo" uniqKey="Murer M" first="M. Gustavo" last="Murer">M. Gustavo Murer</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>7 aut.</sZ></inist:fA14><country>Argentine</country><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gershanik, Oscar" sort="Gershanik, Oscar" uniqKey="Gershanik O" first="Oscar" last="Gershanik">Oscar Gershanik</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Instituto de Investigaciones Farmacológicas (ININFA), UBA-CONICET</s1><s2>Buenos Aires</s2><s3>ARG</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Argentine</country><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of neurochemistry</title><title level="j" type="abbreviated">J. neurochem.</title><idno type="ISSN">0022-3042</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neurochemistry</title><title level="j" type="abbreviated">J. neurochem.</title><idno type="ISSN">0022-3042</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Antiparkinson agent</term><term>Basic protein</term><term>Calmodulin</term><term>Chronic</term><term>Corpus striatum</term><term>Gene expression</term><term>Lesion</term><term>Levodopa</term><term>Myelin</term><term>Nigrostriatal pathway</term><term>Parkinson disease</term><term>Plasticity</term><term>Rat</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Expression génique</term><term>Chronique</term><term>Lévodopa</term><term>Corps strié</term><term>Lésion</term><term>Voie nigrostriatale</term><term>Calmoduline</term><term>Myéline</term><term>Parkinson maladie</term><term>Protéine basique</term><term>Plasticité</term><term>Antiparkinsonien</term><term>Animal</term><term>Rat</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa, the major treatment for patients with Parkinson's disease, has been shown to induce a variety of compensatory effects, including facilitation of sprouting by dopaminergic neurons, in experimental animals with lesions leading to denervation of the striatum. To better understand the cellular and molecular environment where most of these compensatory changes take place, in particular elements that might contribute to the recovery of dopaminergic innervation, we have constructed a differential expression library enriched in transcripts from the striata of rats with lesions of the medial forebrain bundle treated with levodopa for 6 months. We have used this library to screen an expression array of rat genes representing the major cell functions, and have identified several that are involved in neurotrophic mechanisms and plasticity. We have confirmed the differential expression of selected transcripts by non-radioactive in situ hybridization, and report that the growth factor pleiotrophin, myelin basic protein and calmodulin are overexpressed in the denervated striatum of levodopa-treated rats.</div></front></TEI><affiliations><list><country><li>Argentine</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="Argentine"><noRegion><name sortKey="Ferrario, Juan E" sort="Ferrario, Juan E" uniqKey="Ferrario J" first="Juan E." last="Ferrario">Juan E. Ferrario</name></noRegion><name sortKey="Delfino, Marina A" sort="Delfino, Marina A" uniqKey="Delfino M" first="Marina A." last="Delfino">Marina A. Delfino</name><name sortKey="Gershanik, Oscar" sort="Gershanik, Oscar" uniqKey="Gershanik O" first="Oscar" last="Gershanik">Oscar Gershanik</name><name sortKey="Murer, M Gustavo" sort="Murer, M Gustavo" uniqKey="Murer M" first="M. Gustavo" last="Murer">M. Gustavo Murer</name><name sortKey="Stefano, Andrea" sort="Stefano, Andrea" uniqKey="Stefano A" first="Andrea" last="Stefano">Andrea Stefano</name><name sortKey="Taravini, Irene R E" sort="Taravini, Irene R E" uniqKey="Taravini I" first="Irene R. E." last="Taravini">Irene R. E. Taravini</name></country><country name="France"><region name="Île-de-France"><name sortKey="Mourlevat, Sophie" sort="Mourlevat, Sophie" uniqKey="Mourlevat S" first="Sophie" last="Mourlevat">Sophie Mourlevat</name></region><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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