Differential contribution of dopamine D2S and D2L receptors in the modulation of glutamate and GABA transmission in the striatum
Identifieur interne : 003024 ( Main/Exploration ); précédent : 003023; suivant : 003025Differential contribution of dopamine D2S and D2L receptors in the modulation of glutamate and GABA transmission in the striatum
Auteurs : D. Centonze [Italie] ; P. Gubellini [Italie, France] ; A. Usiello [France] ; S. Rossi [Italie] ; A. Tscherter [Italie] ; E. Bracci [Italie, Royaume-Uni] ; E. Erbs [France] ; N. Tognazzi [France] ; G. Bernardi [Italie] ; A. Pisani [Italie] ; P. Calabresi [Italie] ; E. Borrelli [France]Source :
- Neuroscience [ 0306-4522 ] ; 2004.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Animal transgénique.
English descriptors
- KwdEn :
Abstract
Compelling evidence indicates that the long (D2L) and the short (D2S) isoform of dopamine (DA) D2 receptors serve distinct physiological functions in vivo. To address the involvement of these isoforms in the control of synaptic transmission in the striatum, we measured the sensitivity to D2 receptor stimulation of glutamate- and GABA-mediated currents recorded from striatal neurons of three mutant mice, in which the expression of D2L and D2S receptors was either ablated or variably altered. Our data indicate that both isoforms participate in the presynaptic inhibition of GABA transmission in the striatum, while the D2-receptor-dependent modulation of glutamate release preferentially involves the D2S receptor. Accordingly, the inhibitory effects of the DA D2 receptor agonist quinpirole (10 μM) on GABAA-mediated spontaneous inhibitory postsynaptic currents (IPSCs) correlate with the total number of D2 receptor sites in the striatum, irrespective of the specific receptor isoform expressed. In contrast, glutamate-mediated spontaneous excitatory postsynaptic currents (EPSCs) were significantly inhibited by quinpirole only when the total number of D2 receptor sites, normally composed by both D2L and D2S receptors in a ratio favoring the D2L isoform, was modified to express only the D2S isoform at higher than normal levels. Understanding the physiological roles of DA D2 receptors in the striatum is essential for the treatment of several neuropsychiatric conditions, such as Parkinson's disease, Tourette's syndrome, schizophrenia, and drug addiction.
Affiliations:
- France, Italie, Royaume-Uni
- Alsace (région administrative), Grand Est, Latium, Provence-Alpes-Côte d'Azur
- Illkirch, Marseille, Rome
- Université de la Méditerranée
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Centonze</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinica Neurologica, Dipartimento di Neuroscienze, Università "Tor Vergata, " Via Montpellier 1</s1><s2>00133 Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS Fondazione Santa Lucia, Via Ardeatina 306</s1><s2>00179, Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Gubellini, P" sort="Gubellini, P" uniqKey="Gubellini P" first="P." last="Gubellini">P. 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Fries, BP10142</s1><s2>67404 Illkirch</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Illkirch</settlement></placeName></affiliation></author><author><name sortKey="Bernardi, G" sort="Bernardi, G" uniqKey="Bernardi G" first="G." last="Bernardi">G. Bernardi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinica Neurologica, Dipartimento di Neuroscienze, Università "Tor Vergata, " Via Montpellier 1</s1><s2>00133 Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS Fondazione Santa Lucia, Via Ardeatina 306</s1><s2>00179, Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Pisani, A" sort="Pisani, A" uniqKey="Pisani A" first="A." last="Pisani">A. 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Calabresi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinica Neurologica, Dipartimento di Neuroscienze, Università "Tor Vergata, " Via Montpellier 1</s1><s2>00133 Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS Fondazione Santa Lucia, Via Ardeatina 306</s1><s2>00179, Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Borrelli, E" sort="Borrelli, E" uniqKey="Borrelli E" first="E." last="Borrelli">E. Borrelli</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Medicale-ULP, Rue L. Fries, BP10142</s1><s2>67404 Illkirch</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Illkirch</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">04-0596648</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 04-0596648 INIST</idno><idno type="RBID">Pascal:04-0596648</idno><idno type="wicri:Area/PascalFrancis/Corpus">000D48</idno><idno type="wicri:Area/PascalFrancis/Curation">000686</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000C54</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000C54</idno><idno type="wicri:doubleKey">0306-4522:2004:Centonze D:differential:contribution:of</idno><idno type="wicri:Area/Main/Merge">003454</idno><idno type="wicri:Area/Main/Curation">003024</idno><idno type="wicri:Area/Main/Exploration">003024</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Differential contribution of dopamine D2S and D2L receptors in the modulation of glutamate and GABA transmission in the striatum</title><author><name sortKey="Centonze, D" sort="Centonze, D" uniqKey="Centonze D" first="D." last="Centonze">D. Centonze</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinica Neurologica, Dipartimento di Neuroscienze, Università "Tor Vergata, " Via Montpellier 1</s1><s2>00133 Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS Fondazione Santa Lucia, Via Ardeatina 306</s1><s2>00179, Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Gubellini, P" sort="Gubellini, P" uniqKey="Gubellini P" first="P." last="Gubellini">P. Gubellini</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinica Neurologica, Dipartimento di Neuroscienze, Università "Tor Vergata, " Via Montpellier 1</s1><s2>00133 Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS Fondazione Santa Lucia, Via Ardeatina 306</s1><s2>00179, Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Interactions Cellulaires, Neurodégénérescence et Neuroplasticité (IC2N-UMR6186), CNRS-Université de la Méditerranée</s1><s2>Marseille</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université de la Méditerranée</orgName></affiliation></author><author><name sortKey="Usiello, A" sort="Usiello, A" uniqKey="Usiello A" first="A." last="Usiello">A. Usiello</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Medicale-ULP, Rue L. Fries, BP10142</s1><s2>67404 Illkirch</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Illkirch</settlement></placeName></affiliation></author><author><name sortKey="Rossi, S" sort="Rossi, S" uniqKey="Rossi S" first="S." last="Rossi">S. Rossi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinica Neurologica, Dipartimento di Neuroscienze, Università "Tor Vergata, " Via Montpellier 1</s1><s2>00133 Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS Fondazione Santa Lucia, Via Ardeatina 306</s1><s2>00179, Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Tscherter, A" sort="Tscherter, A" uniqKey="Tscherter A" first="A." last="Tscherter">A. Tscherter</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinica Neurologica, Dipartimento di Neuroscienze, Università "Tor Vergata, " Via Montpellier 1</s1><s2>00133 Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS Fondazione Santa Lucia, Via Ardeatina 306</s1><s2>00179, Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bracci, E" sort="Bracci, E" uniqKey="Bracci E" first="E." last="Bracci">E. Bracci</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinica Neurologica, Dipartimento di Neuroscienze, Università "Tor Vergata, " Via Montpellier 1</s1><s2>00133 Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS Fondazione Santa Lucia, Via Ardeatina 306</s1><s2>00179, Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Optometry and Neuroscience, UMIST</s1><s2>Manchester M60 1QD</s2><s3>GBR</s3><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Manchester M60 1QD</wicri:noRegion></affiliation></author><author><name sortKey="Erbs, E" sort="Erbs, E" uniqKey="Erbs E" first="E." last="Erbs">E. Erbs</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Medicale-ULP, Rue L. Fries, BP10142</s1><s2>67404 Illkirch</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Illkirch</settlement></placeName></affiliation></author><author><name sortKey="Tognazzi, N" sort="Tognazzi, N" uniqKey="Tognazzi N" first="N." last="Tognazzi">N. Tognazzi</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Medicale-ULP, Rue L. Fries, BP10142</s1><s2>67404 Illkirch</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Illkirch</settlement></placeName></affiliation></author><author><name sortKey="Bernardi, G" sort="Bernardi, G" uniqKey="Bernardi G" first="G." last="Bernardi">G. Bernardi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinica Neurologica, Dipartimento di Neuroscienze, Università "Tor Vergata, " Via Montpellier 1</s1><s2>00133 Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS Fondazione Santa Lucia, Via Ardeatina 306</s1><s2>00179, Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Pisani, A" sort="Pisani, A" uniqKey="Pisani A" first="A." last="Pisani">A. Pisani</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinica Neurologica, Dipartimento di Neuroscienze, Università "Tor Vergata, " Via Montpellier 1</s1><s2>00133 Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS Fondazione Santa Lucia, Via Ardeatina 306</s1><s2>00179, Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Calabresi, P" sort="Calabresi, P" uniqKey="Calabresi P" first="P." last="Calabresi">P. Calabresi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinica Neurologica, Dipartimento di Neuroscienze, Università "Tor Vergata, " Via Montpellier 1</s1><s2>00133 Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>IRCCS Fondazione Santa Lucia, Via Ardeatina 306</s1><s2>00179, Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Borrelli, E" sort="Borrelli, E" uniqKey="Borrelli E" first="E." last="Borrelli">E. Borrelli</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Medicale-ULP, Rue L. Fries, BP10142</s1><s2>67404 Illkirch</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Illkirch</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglion</term><term>Corpus striatum</term><term>D2L dopamine receptor</term><term>D2S dopamine receptor</term><term>Electrophysiology</term><term>Excitatory postsynaptic current</term><term>GABA</term><term>Glutamatergic transmission</term><term>Inhibitory postsynaptic current</term><term>Synaptic transmission</term><term>Transgenic animal</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Récepteur dopaminergique D2S</term><term>Récepteur dopaminergique D2L</term><term>Transmission glutamatergique</term><term>GABA</term><term>Corps strié</term><term>Noyau gris central</term><term>Electrophysiologie</term><term>Courant postsynaptique excitateur</term><term>Courant postsynaptique inhibiteur</term><term>Transmission synaptique</term><term>Animal transgénique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Animal transgénique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Compelling evidence indicates that the long (D2L) and the short (D2S) isoform of dopamine (DA) D2 receptors serve distinct physiological functions in vivo. To address the involvement of these isoforms in the control of synaptic transmission in the striatum, we measured the sensitivity to D2 receptor stimulation of glutamate- and GABA-mediated currents recorded from striatal neurons of three mutant mice, in which the expression of D2L and D2S receptors was either ablated or variably altered. Our data indicate that both isoforms participate in the presynaptic inhibition of GABA transmission in the striatum, while the D2-receptor-dependent modulation of glutamate release preferentially involves the D2S receptor. Accordingly, the inhibitory effects of the DA D2 receptor agonist quinpirole (10 μM) on GABA<sub>A</sub>-mediated spontaneous inhibitory postsynaptic currents (IPSCs) correlate with the total number of D2 receptor sites in the striatum, irrespective of the specific receptor isoform expressed. In contrast, glutamate-mediated spontaneous excitatory postsynaptic currents (EPSCs) were significantly inhibited by quinpirole only when the total number of D2 receptor sites, normally composed by both D2L and D2S receptors in a ratio favoring the D2L isoform, was modified to express only the D2S isoform at higher than normal levels. Understanding the physiological roles of DA D2 receptors in the striatum is essential for the treatment of several neuropsychiatric conditions, such as Parkinson's disease, Tourette's syndrome, schizophrenia, and drug addiction.</div></front></TEI><affiliations><list><country><li>France</li><li>Italie</li><li>Royaume-Uni</li></country><region><li>Alsace (région administrative)</li><li>Grand Est</li><li>Latium</li><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Illkirch</li><li>Marseille</li><li>Rome</li></settlement><orgName><li>Université de la Méditerranée</li></orgName></list><tree><country name="Italie"><region name="Latium"><name sortKey="Centonze, D" sort="Centonze, D" uniqKey="Centonze D" first="D." last="Centonze">D. Centonze</name></region><name sortKey="Bernardi, G" sort="Bernardi, G" uniqKey="Bernardi G" first="G." last="Bernardi">G. Bernardi</name><name sortKey="Bernardi, G" sort="Bernardi, G" uniqKey="Bernardi G" first="G." last="Bernardi">G. Bernardi</name><name sortKey="Bracci, E" sort="Bracci, E" uniqKey="Bracci E" first="E." last="Bracci">E. Bracci</name><name sortKey="Bracci, E" sort="Bracci, E" uniqKey="Bracci E" first="E." last="Bracci">E. Bracci</name><name sortKey="Calabresi, P" sort="Calabresi, P" uniqKey="Calabresi P" first="P." last="Calabresi">P. Calabresi</name><name sortKey="Calabresi, P" sort="Calabresi, P" uniqKey="Calabresi P" first="P." last="Calabresi">P. Calabresi</name><name sortKey="Centonze, D" sort="Centonze, D" uniqKey="Centonze D" first="D." last="Centonze">D. Centonze</name><name sortKey="Gubellini, P" sort="Gubellini, P" uniqKey="Gubellini P" first="P." last="Gubellini">P. Gubellini</name><name sortKey="Gubellini, P" sort="Gubellini, P" uniqKey="Gubellini P" first="P." last="Gubellini">P. Gubellini</name><name sortKey="Pisani, A" sort="Pisani, A" uniqKey="Pisani A" first="A." last="Pisani">A. Pisani</name><name sortKey="Pisani, A" sort="Pisani, A" uniqKey="Pisani A" first="A." last="Pisani">A. Pisani</name><name sortKey="Rossi, S" sort="Rossi, S" uniqKey="Rossi S" first="S." last="Rossi">S. Rossi</name><name sortKey="Rossi, S" sort="Rossi, S" uniqKey="Rossi S" first="S." last="Rossi">S. Rossi</name><name sortKey="Tscherter, A" sort="Tscherter, A" uniqKey="Tscherter A" first="A." last="Tscherter">A. Tscherter</name><name sortKey="Tscherter, A" sort="Tscherter, A" uniqKey="Tscherter A" first="A." last="Tscherter">A. Tscherter</name></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Gubellini, P" sort="Gubellini, P" uniqKey="Gubellini P" first="P." last="Gubellini">P. Gubellini</name></region><name sortKey="Borrelli, E" sort="Borrelli, E" uniqKey="Borrelli E" first="E." last="Borrelli">E. Borrelli</name><name sortKey="Erbs, E" sort="Erbs, E" uniqKey="Erbs E" first="E." last="Erbs">E. Erbs</name><name sortKey="Tognazzi, N" sort="Tognazzi, N" uniqKey="Tognazzi N" first="N." last="Tognazzi">N. Tognazzi</name><name sortKey="Usiello, A" sort="Usiello, A" uniqKey="Usiello A" first="A." last="Usiello">A. Usiello</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Bracci, E" sort="Bracci, E" uniqKey="Bracci E" first="E." last="Bracci">E. Bracci</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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