ParkinsonFranceV1, Main, Exploration, bibRecordById, Pascal:00-0531976

Parkinson's disease, smoking, and family history

Identifieur interne : 003B64 ( Main/Exploration ); précédent : 003B63; suivant : 003B65

Parkinson's disease, smoking, and family history

Auteurs : Alexis Elbaz [France] ; José Maria Manubens-Bertran [Espagne] ; Marzia Baldereschi [Italie] ; Monique M. B. Breteler [Pays-Bas] ; Francesco Grigoletto [Italie] ; Secundino Lopez-Pousa [Espagne] ; Jean-Francois Dartigues [France] ; Annick Alperovitch [France] ; Walter A. Rocca [États-Unis] ; Christophe Tzourio [France]

Source :

Journal of neurology [ 0340-5354 ] ; 2000.

RBID : Pascal:00-0531976

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Tabagisme, Histoire familiale, Europe, Epidémiologie, Facteur risque, Homme, Etude cas témoin.
Wicri :
- topic : Tabagisme, Homme.

English descriptors

KwdEn :
- Age of Onset, Aged, Aged, 80 and over, Case control study, Epidemiologic Studies, Epidemiology, Europe, Europe (epidemiology), Family story, Female, Genetic Predisposition to Disease, Human, Humans, Male, Middle Aged, Parkinson Disease (epidemiology), Parkinson Disease (etiology), Parkinson Disease (genetics), Parkinson disease, Prevalence, Risk Factors, Risk factor, Smoking (adverse effects), Tobacco smoking.
MESH :
- geographic , epidemiology : Europe.
- adverse effects : Smoking.
- epidemiology : Parkinson Disease.
- etiology : Parkinson Disease.
- genetics : Parkinson Disease.
- Age of Onset, Aged, Aged, 80 and over, Epidemiologic Studies, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Prevalence, Risk Factors.

Abstract

There is growing evidence that both genetic and environmental factors play a role in the etiology of Parkinson's disease (PD). The hypothesis of an interaction between genetic and environmental risk factors has been little explored, and never using a population-based case-control study design. Our objective was to investigate the possible interaction between smoking and family history in the etiology of PD, as part of a collaborative population-based case-control study. We included 149 nondemented PD patients ascertained in three European prevalence surveys using a two-phase design. Each patient was matched by age (±2 years), gender, and center to three controls drawn from the same populations (n=375). Presence of PD among first-degree relatives and smoking history were assessed through an interview for 127 cases and 306 controls. In the overall sample we found suggestive evidence that family history and eversmoking interact in determining the risk of PD (P=0.09), with individuals exposed to both risk factors having the highest risk (OR=10.0; 95 % CI=2.0-49.6). Analyses were repeated after stratification into two age-groups (cutoff: 75 years). In older patients, the joint exposure to both risk factors was associated with a significant increase in the risk of PD (OR=17.6; 95 % CI=1.9-160.5). Among younger subjects, the OR for joint exposure was not significant. In conclusion, our findings suggest that smoking and family history interact synergistically on a multiplicative scale in determining the risk of PD in individuals older than 75 years.

Affiliations:

Espagne, France, Italie, Pays-Bas, États-Unis
Aquitaine, Hollande-Méridionale, Nouvelle-Aquitaine, Île-de-France
Bordeaux, Paris, Rotterdam

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term>
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<front><div type="abstract" xml:lang="en">There is growing evidence that both genetic and environmental factors play a role in the etiology of Parkinson's disease (PD). The hypothesis of an interaction between genetic and environmental risk factors has been little explored, and never using a population-based case-control study design. Our objective was to investigate the possible interaction between smoking and family history in the etiology of PD, as part of a collaborative population-based case-control study. We included 149 nondemented PD patients ascertained in three European prevalence surveys using a two-phase design. Each patient was matched by age (±2 years), gender, and center to three controls drawn from the same populations (n=375). Presence of PD among first-degree relatives and smoking history were assessed through an interview for 127 cases and 306 controls. In the overall sample we found suggestive evidence that family history and eversmoking interact in determining the risk of PD (P=0.09), with individuals exposed to both risk factors having the highest risk (OR=10.0; 95 % CI=2.0-49.6). Analyses were repeated after stratification into two age-groups (cutoff: 75 years). In older patients, the joint exposure to both risk factors was associated with a significant increase in the risk of PD (OR=17.6; 95 % CI=1.9-160.5). Among younger subjects, the OR for joint exposure was not significant. In conclusion, our findings suggest that smoking and family history interact synergistically on a multiplicative scale in determining the risk of PD in individuals older than 75 years.</div>
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<name sortKey="Grigoletto, Francesco" sort="Grigoletto, Francesco" uniqKey="Grigoletto F" first="Francesco" last="Grigoletto">Francesco Grigoletto</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name>
</region>
</country>
<country name="États-Unis"><noRegion><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003B64 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003B64 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:00-0531976
   |texte=   Parkinson's disease, smoking, and family history
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

La maladie de Parkinson en France (serveur d'exploration)

Parkinson's disease, smoking, and family history

Parkinson's disease, smoking, and family history

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.