Parkinson's disease, smoking, and family history
Identifieur interne : 001186 ( PascalFrancis/Checkpoint ); précédent : 001185; suivant : 001187Parkinson's disease, smoking, and family history
Auteurs : Alexis Elbaz [France] ; José Maria Manubens-Bertran [Espagne] ; Marzia Baldereschi [Italie] ; Monique M. B. Breteler [Pays-Bas] ; Francesco Grigoletto [Italie] ; Secundino Lopez-Pousa [Espagne] ; Jean-Francois Dartigues [France] ; Annick Alperovitch [France] ; Walter A. Rocca [États-Unis] ; Christophe Tzourio [France]Source :
- Journal of neurology [ 0340-5354 ] ; 2000.
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Abstract
There is growing evidence that both genetic and environmental factors play a role in the etiology of Parkinson's disease (PD). The hypothesis of an interaction between genetic and environmental risk factors has been little explored, and never using a population-based case-control study design. Our objective was to investigate the possible interaction between smoking and family history in the etiology of PD, as part of a collaborative population-based case-control study. We included 149 nondemented PD patients ascertained in three European prevalence surveys using a two-phase design. Each patient was matched by age (±2 years), gender, and center to three controls drawn from the same populations (n=375). Presence of PD among first-degree relatives and smoking history were assessed through an interview for 127 cases and 306 controls. In the overall sample we found suggestive evidence that family history and eversmoking interact in determining the risk of PD (P=0.09), with individuals exposed to both risk factors having the highest risk (OR=10.0; 95 % CI=2.0-49.6). Analyses were repeated after stratification into two age-groups (cutoff: 75 years). In older patients, the joint exposure to both risk factors was associated with a significant increase in the risk of PD (OR=17.6; 95 % CI=1.9-160.5). Among younger subjects, the OR for joint exposure was not significant. In conclusion, our findings suggest that smoking and family history interact synergistically on a multiplicative scale in determining the risk of PD in individuals older than 75 years.
Affiliations:
- Espagne, France, Italie, Pays-Bas, États-Unis
- Aquitaine, Hollande-Méridionale, Nouvelle-Aquitaine, Île-de-France
- Bordeaux, Paris, Rotterdam
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B." last="Breteler">Monique M. B. Breteler</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Epidemiology and Biostatistics, Erasmus University Medical School</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Grigoletto, Francesco" sort="Grigoletto, Francesco" uniqKey="Grigoletto F" first="Francesco" last="Grigoletto">Francesco Grigoletto</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Hygiene, University of Padua</s1><s2>Padua</s2><s3>ITA</s3><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Pousa, Secundino" sort="Lopez Pousa, Secundino" uniqKey="Lopez Pousa S" first="Secundino" last="Lopez-Pousa">Secundino Lopez-Pousa</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, University Hospital Sta. Caterina</s1><s2>Girona</s2><s3>ESP</s3><sZ>6 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Girona</wicri:noRegion></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-Francois" last="Dartigues">Jean-Francois Dartigues</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, Pellegrin Hospital, University of Bordeaux II</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alperovitch">Annick Alperovitch</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM U 360, Recherches Epidémiologiques en Neurologie et Psychopathologie, Hôpital de la Salpêtrière</s1><s2>75651 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Departments of Health Sciences Research and Neurology, Mayo Clinic and Mayo Foundation, 200 First Street SW</s1><s2>Rochester, 55905 MN</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Rochester, 55905 MN</wicri:noRegion></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM U 360, Recherches Epidémiologiques en Neurologie et Psychopathologie, Hôpital de la Salpêtrière</s1><s2>75651 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of neurology</title><title level="j" type="abbreviated">J. neurol.</title><idno type="ISSN">0340-5354</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neurology</title><title level="j" type="abbreviated">J. neurol.</title><idno type="ISSN">0340-5354</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case control study</term><term>Epidemiology</term><term>Europe</term><term>Family story</term><term>Human</term><term>Parkinson disease</term><term>Risk factor</term><term>Tobacco smoking</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Tabagisme</term><term>Histoire familiale</term><term>Europe</term><term>Epidémiologie</term><term>Facteur risque</term><term>Homme</term><term>Etude cas témoin</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Tabagisme</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is growing evidence that both genetic and environmental factors play a role in the etiology of Parkinson's disease (PD). The hypothesis of an interaction between genetic and environmental risk factors has been little explored, and never using a population-based case-control study design. Our objective was to investigate the possible interaction between smoking and family history in the etiology of PD, as part of a collaborative population-based case-control study. We included 149 nondemented PD patients ascertained in three European prevalence surveys using a two-phase design. Each patient was matched by age (±2 years), gender, and center to three controls drawn from the same populations (n=375). Presence of PD among first-degree relatives and smoking history were assessed through an interview for 127 cases and 306 controls. In the overall sample we found suggestive evidence that family history and eversmoking interact in determining the risk of PD (P=0.09), with individuals exposed to both risk factors having the highest risk (OR=10.0; 95 % CI=2.0-49.6). Analyses were repeated after stratification into two age-groups (cutoff: 75 years). In older patients, the joint exposure to both risk factors was associated with a significant increase in the risk of PD (OR=17.6; 95 % CI=1.9-160.5). Among younger subjects, the OR for joint exposure was not significant. In conclusion, our findings suggest that smoking and family history interact synergistically on a multiplicative scale in determining the risk of PD in individuals older than 75 years.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0340-5354</s0></fA01><fA02 i1="01"><s0>JNRYA9</s0></fA02><fA03 i2="1"><s0>J. neurol.</s0></fA03><fA05><s2>247</s2></fA05><fA06><s2>10</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Parkinson's disease, smoking, and family history</s1></fA08><fA11 i1="01" i2="1"><s1>ELBAZ (Alexis)</s1></fA11><fA11 i1="02" i2="1"><s1>MANUBENS-BERTRAN (José Maria)</s1></fA11><fA11 i1="03" i2="1"><s1>BALDERESCHI (Marzia)</s1></fA11><fA11 i1="04" i2="1"><s1>BRETELER (Monique M. 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Caterina</s1><s2>Girona</s2><s3>ESP</s3><sZ>6 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neurology, Pellegrin Hospital, University of Bordeaux II</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="08"><s1>Departments of Health Sciences Research and Neurology, Mayo Clinic and Mayo Foundation, 200 First Street SW</s1><s2>Rochester, 55905 MN</s2><s3>USA</s3><sZ>9 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>EUROPARKINSON Study Group</s1><s3>EUR</s3></fA17><fA20><s1>793-798</s1></fA20><fA21><s1>2000</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>4826</s2><s5>354000092964510080</s5></fA43><fA44><s0>0000</s0><s1>© 2000 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>29 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>00-0531976</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of neurology</s0></fA64><fA66 i1="01"><s0>DEU</s0></fA66><fC01 i1="01" l="ENG"><s0>There is growing evidence that both genetic and environmental factors play a role in the etiology of Parkinson's disease (PD). The hypothesis of an interaction between genetic and environmental risk factors has been little explored, and never using a population-based case-control study design. Our objective was to investigate the possible interaction between smoking and family history in the etiology of PD, as part of a collaborative population-based case-control study. We included 149 nondemented PD patients ascertained in three European prevalence surveys using a two-phase design. Each patient was matched by age (±2 years), gender, and center to three controls drawn from the same populations (n=375). Presence of PD among first-degree relatives and smoking history were assessed through an interview for 127 cases and 306 controls. In the overall sample we found suggestive evidence that family history and eversmoking interact in determining the risk of PD (P=0.09), with individuals exposed to both risk factors having the highest risk (OR=10.0; 95 % CI=2.0-49.6). Analyses were repeated after stratification into two age-groups (cutoff: 75 years). In older patients, the joint exposure to both risk factors was associated with a significant increase in the risk of PD (OR=17.6; 95 % CI=1.9-160.5). Among younger subjects, the OR for joint exposure was not significant. In conclusion, our findings suggest that smoking and family history interact synergistically on a multiplicative scale in determining the risk of PD in individuals older than 75 years.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Tabagisme</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Tobacco smoking</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Tabaquismo</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Histoire familiale</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Family story</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Historia familiar</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Europe</s0><s2>NG</s2><s5>16</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Europe</s0><s2>NG</s2><s5>16</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Europa</s0><s2>NG</s2><s5>16</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Epidémiologie</s0><s5>17</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Epidemiology</s0><s5>17</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Epidemiología</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Facteur risque</s0><s5>18</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Risk factor</s0><s5>18</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Factor riesgo</s0><s5>18</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Homme</s0><s5>20</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Human</s0><s5>20</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Hombre</s0><s5>20</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Etude cas témoin</s0><s5>23</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Case control study</s0><s5>23</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Estudio caso control</s0><s5>23</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fN21><s1>353</s1></fN21></pA></standard></inist><affiliations><list><country><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Aquitaine</li><li>Hollande-Méridionale</li><li>Nouvelle-Aquitaine</li><li>Île-de-France</li></region><settlement><li>Bordeaux</li><li>Paris</li><li>Rotterdam</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name></region><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alperovitch">Annick Alperovitch</name><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-Francois" last="Dartigues">Jean-Francois Dartigues</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></country><country name="Espagne"><noRegion><name sortKey="Manubens Bertran, Jose Maria" sort="Manubens Bertran, Jose Maria" uniqKey="Manubens Bertran J" first="José Maria" last="Manubens-Bertran">José Maria Manubens-Bertran</name></noRegion><name sortKey="Lopez Pousa, Secundino" sort="Lopez Pousa, Secundino" uniqKey="Lopez Pousa S" first="Secundino" last="Lopez-Pousa">Secundino Lopez-Pousa</name></country><country name="Italie"><noRegion><name sortKey="Baldereschi, Marzia" sort="Baldereschi, Marzia" uniqKey="Baldereschi M" first="Marzia" last="Baldereschi">Marzia Baldereschi</name></noRegion><name sortKey="Grigoletto, Francesco" sort="Grigoletto, Francesco" uniqKey="Grigoletto F" first="Francesco" last="Grigoletto">Francesco Grigoletto</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name></region></country><country name="États-Unis"><noRegion><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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