Parkinson's disease, smoking, and family history. EUROPARKINSON Study Group.
Identifieur interne : 001294 ( PubMed/Corpus ); précédent : 001293; suivant : 001295Parkinson's disease, smoking, and family history. EUROPARKINSON Study Group.
Auteurs : A. Elbaz ; J M Manubens-Bertran ; M. Baldereschi ; M M Breteler ; F. Grigoletto ; S. Lopez-Pousa ; J F Dartigues ; A. Alpérovitch ; W A Rocca ; C. TzourioSource :
- Journal of neurology [ 0340-5354 ] ; 2000.
English descriptors
- KwdEn :
- Age of Onset, Aged, Aged, 80 and over, Epidemiologic Studies, Europe (epidemiology), Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Parkinson Disease (epidemiology), Parkinson Disease (etiology), Parkinson Disease (genetics), Prevalence, Risk Factors, Smoking (adverse effects).
- MESH :
- geographic , epidemiology : Europe.
- adverse effects : Smoking.
- epidemiology : Parkinson Disease.
- etiology : Parkinson Disease.
- genetics : Parkinson Disease.
- Age of Onset, Aged, Aged, 80 and over, Epidemiologic Studies, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Prevalence, Risk Factors.
Abstract
There is growing evidence that both genetic and environmental factors play a role in the etiology of Parkinson's disease (PD). The hypothesis of an interaction between genetic and environmental risk factors has been little explored, and never using a population-based case-control study design. Our objective was to investigate the possible interaction between smoking and family history in the etiology of PD, as part of a collaborative population-based case-control study. We included 149 nondemented PD patients ascertained in three European prevalence surveys using a two-phase design. Each patient was matched by age (+/-2 years), gender, and center to three controls drawn from the same populations (n=375). Presence of PD among first-degree relatives and smoking history were assessed through an interview for 127 cases and 306 controls. In the overall sample we found suggestive evidence that family history and ever-smoking interact in determining the risk of PD (P=0.09), with individuals exposed to both risk factors having the highest risk (OR=10.0; 95% CI=2.0-49.6). Analyses were repeated after stratification into two age-groups (cutoff: 75 years). In older patients, the joint exposure to both risk factors was associated with a significant increase in the risk of PD (OR=17.6; 95% CI=1.9-160.5). Among younger subjects, the OR for joint exposure was not significant. In conclusion, our findings suggest that smoking and family history interact synergistically on a multiplicative scale in determining the risk of PD in individuals older than 75 years.
PubMed: 11127536
Links to Exploration step
pubmed:11127536Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinson's disease, smoking, and family history. EUROPARKINSON Study Group.</title><author><name sortKey="Elbaz, A" sort="Elbaz, A" uniqKey="Elbaz A" first="A" last="Elbaz">A. Elbaz</name><affiliation><nlm:affiliation>INSERM U 360, Recherches Epidémiologiques en Neurologie et Psychopathologie, H pital de la Salpêtrière, Paris, France. elbaz@ccr.jussieu.fr</nlm:affiliation></affiliation></author><author><name sortKey="Manubens Bertran, J M" sort="Manubens Bertran, J M" uniqKey="Manubens Bertran J" first="J M" last="Manubens-Bertran">J M Manubens-Bertran</name></author><author><name sortKey="Baldereschi, M" sort="Baldereschi, M" uniqKey="Baldereschi M" first="M" last="Baldereschi">M. Baldereschi</name></author><author><name sortKey="Breteler, M M" sort="Breteler, M M" uniqKey="Breteler M" first="M M" last="Breteler">M M Breteler</name></author><author><name sortKey="Grigoletto, F" sort="Grigoletto, F" uniqKey="Grigoletto F" first="F" last="Grigoletto">F. Grigoletto</name></author><author><name sortKey="Lopez Pousa, S" sort="Lopez Pousa, S" uniqKey="Lopez Pousa S" first="S" last="Lopez-Pousa">S. Lopez-Pousa</name></author><author><name sortKey="Dartigues, J F" sort="Dartigues, J F" uniqKey="Dartigues J" first="J F" last="Dartigues">J F Dartigues</name></author><author><name sortKey="Alperovitch, A" sort="Alperovitch, A" uniqKey="Alperovitch A" first="A" last="Alpérovitch">A. Alpérovitch</name></author><author><name sortKey="Rocca, W A" sort="Rocca, W A" uniqKey="Rocca W" first="W A" last="Rocca">W A Rocca</name></author><author><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C" last="Tzourio">C. Tzourio</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:11127536</idno><idno type="pmid">11127536</idno><idno type="wicri:Area/PubMed/Corpus">001294</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001294</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Parkinson's disease, smoking, and family history. EUROPARKINSON Study Group.</title><author><name sortKey="Elbaz, A" sort="Elbaz, A" uniqKey="Elbaz A" first="A" last="Elbaz">A. Elbaz</name><affiliation><nlm:affiliation>INSERM U 360, Recherches Epidémiologiques en Neurologie et Psychopathologie, H pital de la Salpêtrière, Paris, France. elbaz@ccr.jussieu.fr</nlm:affiliation></affiliation></author><author><name sortKey="Manubens Bertran, J M" sort="Manubens Bertran, J M" uniqKey="Manubens Bertran J" first="J M" last="Manubens-Bertran">J M Manubens-Bertran</name></author><author><name sortKey="Baldereschi, M" sort="Baldereschi, M" uniqKey="Baldereschi M" first="M" last="Baldereschi">M. Baldereschi</name></author><author><name sortKey="Breteler, M M" sort="Breteler, M M" uniqKey="Breteler M" first="M M" last="Breteler">M M Breteler</name></author><author><name sortKey="Grigoletto, F" sort="Grigoletto, F" uniqKey="Grigoletto F" first="F" last="Grigoletto">F. Grigoletto</name></author><author><name sortKey="Lopez Pousa, S" sort="Lopez Pousa, S" uniqKey="Lopez Pousa S" first="S" last="Lopez-Pousa">S. Lopez-Pousa</name></author><author><name sortKey="Dartigues, J F" sort="Dartigues, J F" uniqKey="Dartigues J" first="J F" last="Dartigues">J F Dartigues</name></author><author><name sortKey="Alperovitch, A" sort="Alperovitch, A" uniqKey="Alperovitch A" first="A" last="Alpérovitch">A. Alpérovitch</name></author><author><name sortKey="Rocca, W A" sort="Rocca, W A" uniqKey="Rocca W" first="W A" last="Rocca">W A Rocca</name></author><author><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C" last="Tzourio">C. Tzourio</name></author></analytic><series><title level="j">Journal of neurology</title><idno type="ISSN">0340-5354</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Epidemiologic Studies</term><term>Europe (epidemiology)</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (genetics)</term><term>Prevalence</term><term>Risk Factors</term><term>Smoking (adverse effects)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Epidemiologic Studies</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is growing evidence that both genetic and environmental factors play a role in the etiology of Parkinson's disease (PD). The hypothesis of an interaction between genetic and environmental risk factors has been little explored, and never using a population-based case-control study design. Our objective was to investigate the possible interaction between smoking and family history in the etiology of PD, as part of a collaborative population-based case-control study. We included 149 nondemented PD patients ascertained in three European prevalence surveys using a two-phase design. Each patient was matched by age (+/-2 years), gender, and center to three controls drawn from the same populations (n=375). Presence of PD among first-degree relatives and smoking history were assessed through an interview for 127 cases and 306 controls. In the overall sample we found suggestive evidence that family history and ever-smoking interact in determining the risk of PD (P=0.09), with individuals exposed to both risk factors having the highest risk (OR=10.0; 95% CI=2.0-49.6). Analyses were repeated after stratification into two age-groups (cutoff: 75 years). In older patients, the joint exposure to both risk factors was associated with a significant increase in the risk of PD (OR=17.6; 95% CI=1.9-160.5). Among younger subjects, the OR for joint exposure was not significant. In conclusion, our findings suggest that smoking and family history interact synergistically on a multiplicative scale in determining the risk of PD in individuals older than 75 years.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11127536</PMID><DateCreated><Year>2000</Year><Month>12</Month><Day>20</Day></DateCreated><DateCompleted><Year>2001</Year><Month>02</Month><Day>15</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0340-5354</ISSN><JournalIssue CitedMedium="Print"><Volume>247</Volume><Issue>10</Issue><PubDate><Year>2000</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of neurology</Title><ISOAbbreviation>J. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Parkinson's disease, smoking, and family history. EUROPARKINSON Study Group.</ArticleTitle><Pagination><MedlinePgn>793-8</MedlinePgn></Pagination><Abstract><AbstractText>There is growing evidence that both genetic and environmental factors play a role in the etiology of Parkinson's disease (PD). The hypothesis of an interaction between genetic and environmental risk factors has been little explored, and never using a population-based case-control study design. Our objective was to investigate the possible interaction between smoking and family history in the etiology of PD, as part of a collaborative population-based case-control study. We included 149 nondemented PD patients ascertained in three European prevalence surveys using a two-phase design. Each patient was matched by age (+/-2 years), gender, and center to three controls drawn from the same populations (n=375). Presence of PD among first-degree relatives and smoking history were assessed through an interview for 127 cases and 306 controls. In the overall sample we found suggestive evidence that family history and ever-smoking interact in determining the risk of PD (P=0.09), with individuals exposed to both risk factors having the highest risk (OR=10.0; 95% CI=2.0-49.6). Analyses were repeated after stratification into two age-groups (cutoff: 75 years). In older patients, the joint exposure to both risk factors was associated with a significant increase in the risk of PD (OR=17.6; 95% CI=1.9-160.5). Among younger subjects, the OR for joint exposure was not significant. In conclusion, our findings suggest that smoking and family history interact synergistically on a multiplicative scale in determining the risk of PD in individuals older than 75 years.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Elbaz</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>INSERM U 360, Recherches Epidémiologiques en Neurologie et Psychopathologie, H pital de la Salpêtrière, Paris, France. elbaz@ccr.jussieu.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manubens-Bertran</LastName><ForeName>J M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Baldereschi</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Breteler</LastName><ForeName>M M</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>Grigoletto</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Lopez-Pousa</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Dartigues</LastName><ForeName>J F</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Alpérovitch</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Rocca</LastName><ForeName>W A</ForeName><Initials>WA</Initials></Author><Author ValidYN="Y"><LastName>Tzourio</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>NS 33978</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>J Neurol</MedlineTA><NlmUniqueID>0423161</NlmUniqueID><ISSNLinking>0340-5354</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D017668" MajorTopicYN="N">Age of Onset</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016021" MajorTopicYN="N">Epidemiologic Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N" Type="Geographic">Europe</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="Y">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012907" MajorTopicYN="N">Smoking</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>12</Month><Day>29</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>3</Month><Day>3</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>12</Month><Day>29</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11127536</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001294 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001294 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:11127536
|texte= Parkinson's disease, smoking, and family history. EUROPARKINSON Study Group.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:11127536" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |