ParkinsonFranceV1, Main, Exploration, bibRecordById, Hal:hal-00093889

Addiction in Parkinson's disease : Impact of subthalamic nucleus deep brain stimulation

Identifieur interne : 002D96 ( Main/Exploration ); précédent : 002D95; suivant : 002D97

Addiction in Parkinson's disease : Impact of subthalamic nucleus deep brain stimulation

Auteurs : Tatiana Witjas [France] ; Christelle Baunez [France] ; Jean Marc Henry [France] ; Marie Delfini [France] ; Jean Regis [France] ; André Ali Cherif [France] ; Jean Claude Peragut [France] ; Jean Philippe Azulay [France]

Source :

Movement disorders [ 0885-3185 ] ; 2005.

RBID : Pascal:05-0444034

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Addiction, Parkinson maladie, Dyskinésie, Substance toxicomanogène, Noyau sousthalamique, Dopamine, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Addiction, Adult, Behavior, Addictive (complications), Behavior, Addictive (therapy), Clinical Protocols, Deep Brain Stimulation (methods), Deep brain stimulation, Dopamine, Drug of abuse, Dyskinesia, Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (therapy), Parkinson disease, Subthalamic Nucleus (radiation effects), Subthalamic nucleus.
MESH :
- complications : Behavior, Addictive, Parkinson Disease.
- methods : Deep Brain Stimulation.
- radiation effects : Subthalamic Nucleus.
- therapy : Behavior, Addictive, Parkinson Disease.
- Adult, Clinical Protocols, Humans, Male, Middle Aged.

Abstract

In Parkinson's disease, dopamine dysregulation syndrome (DDS) is characterized by severe dopamine addiction and behavioral disorders such as manic psychosis, hypersexuality, pathological gambling, and mood swings. Here, we describe the case of 2 young parkinsonian patients suffering from disabling motor fluctuations and dyskinesia associated with severe DDS. In addition to alleviating the motor disability in both patients, subthalamic nucleus (STN) deep brain stimulation greatly reduced the behavioral disorders as well as completely abolished the addiction to dopaminergic treatment. Dopaminergic addiction in patients with Parkinson's disease, therefore, does not constitute an obstacle to high-frequency STN stimulation, and this treatment may even cure the addiction.

Url:

https://hal.archives-ouvertes.fr/hal-00093889

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">In Parkinson's disease, dopamine dysregulation syndrome (DDS) is characterized by severe dopamine addiction and behavioral disorders such as manic psychosis, hypersexuality, pathological gambling, and mood swings. Here, we describe the case of 2 young parkinsonian patients suffering from disabling motor fluctuations and dyskinesia associated with severe DDS. In addition to alleviating the motor disability in both patients, subthalamic nucleus (STN) deep brain stimulation greatly reduced the behavioral disorders as well as completely abolished the addiction to dopaminergic treatment. Dopaminergic addiction in patients with Parkinson's disease, therefore, does not constitute an obstacle to high-frequency STN stimulation, and this treatment may even cure the addiction.</div>
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La maladie de Parkinson en France (serveur d'exploration)

Addiction in Parkinson's disease : Impact of subthalamic nucleus deep brain stimulation

Addiction in Parkinson's disease : Impact of subthalamic nucleus deep brain stimulation

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	La maladie de Parkinson en France (serveur d'exploration)
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