ParkinsonFranceV1, Hal, Curation, bibRecord, 000053

Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate

Identifieur interne : 000053 ( Hal/Curation ); précédent : 000052; suivant : 000054

Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate

Auteurs : Marie-Hélène Canron [France] ; Martine Perret [France] ; Anne Vital [France] ; Erwan Bezard [France] ; Benjamin Dehay [France]

Source :

Scientific Reports [ 2045-2322 ] ; 2012-01-02.

RBID : Hal:hal-01053267

Abstract

Since age-dependent deposition of Aβ-amyloid has been reported in the Microcebusmurinus, we posited that this animal could as well be a model of age-related synucleinopathy. We characterized the distribution of Aβ-amyloid, α-synuclein and two of its modified forms in the brain of Microcebusmurinus aged from 1.5 to 10 years. Intracytoplasmic α-synuclein aggregates were observed only in aged animals in different brain regions, which were also phospho-Ser129 and nitrated α-synuclein immunoreactive. Age-dependent α-synuclein aggregation occurs spontaneously in mouse lemur primates. Microcebus murinus may provide a model to study age-associated α-synucleinopathy and for testing putative therapeutic interventions for both Alzheimer's and Parkinson's diseases.

Url:

https://hal.archives-ouvertes.fr/hal-01053267

DOI: 10.1038/srep00910

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Le document en format XML

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate

Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate

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