Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.
Identifieur interne : 000575 ( Main/Exploration ); précédent : 000574; suivant : 000576Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.
Auteurs : Lars Timmermann [Allemagne] ; Roshini Jain [États-Unis] ; Lilly Chen [États-Unis] ; Mohamed Maarouf [Allemagne] ; Michael T. Barbe [Allemagne] ; Niels Allert [Allemagne] ; Thomas Brücke [Autriche] ; Iris Kaiser [Autriche] ; Sebastian Beirer [Autriche] ; Fernando Sejio [Espagne] ; Esther Suarez [Espagne] ; Beatriz Lozano [Espagne] ; Claire Haegelen [France] ; Marc Vérin [France] ; Mauro Porta [Italie] ; Domenico Servello [Italie] ; Steven Gill [Royaume-Uni] ; Alan Whone [Royaume-Uni] ; Nic Van Dyck [Pays-Bas] ; Francois Alesch [Autriche]Source :
- The Lancet. Neurology [ 1474-4465 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Parkinson Disease.
- instrumentation : Deep Brain Stimulation.
- methods : Deep Brain Stimulation.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Adult, Aged, Electrodes, Implanted, Female, Humans, Male, Middle Aged, Prospective Studies, Treatment Outcome.
Abstract
High-frequency deep brain stimulation (DBS) with a single electrical source is effective for motor symptom relief in patients with Parkinson's disease. We postulated that a multiple-source, constant-current device that permits well defined distribution of current would lead to motor improvement in patients with Parkinson's disease.
Url:
DOI: 10.1016/S1474-4422(15)00087-3
PubMed: 26027940
Affiliations:
- Allemagne, Autriche, Espagne, France, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Californie, Lombardie, Région Bretagne, Vienne (Autriche)
- Milan, Rennes, Vienne (Autriche)
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Le document en format XML
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xml:lang="en">Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.</title><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital Cologne, Cologne, Germany. Electronic address: lars.timmermann@uk-koeln.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Jain, Roshini" sort="Jain, Roshini" uniqKey="Jain R" first="Roshini" last="Jain">Roshini Jain</name><affiliation wicri:level="2"><nlm:affiliation>Boston Scientific, Neuromodulation, Valencia, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston Scientific, Neuromodulation, Valencia, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chen, Lilly" sort="Chen, Lilly" uniqKey="Chen L" first="Lilly" last="Chen">Lilly Chen</name><affiliation wicri:level="2"><nlm:affiliation>Boston Scientific, Neuromodulation, Valencia, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston Scientific, Neuromodulation, Valencia, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Maarouf, Mohamed" sort="Maarouf, Mohamed" uniqKey="Maarouf M" first="Mohamed" last="Maarouf">Mohamed Maarouf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Barbe, Michael T" sort="Barbe, Michael T" uniqKey="Barbe M" first="Michael T" last="Barbe">Michael T. Barbe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Allert, Niels" sort="Allert, Niels" uniqKey="Allert N" first="Niels" last="Allert">Niels Allert</name><affiliation wicri:level="1"><nlm:affiliation>Neurological Rehabilitation Center, Godeshoehe, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurological Rehabilitation Center, Godeshoehe</wicri:regionArea><wicri:noRegion>Godeshoehe</wicri:noRegion><wicri:noRegion>Godeshoehe</wicri:noRegion><wicri:noRegion>Godeshoehe</wicri:noRegion></affiliation></author><author><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name><affiliation wicri:level="3"><nlm:affiliation>Wilhelminenspital, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Wilhelminenspital, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Kaiser, Iris" sort="Kaiser, Iris" uniqKey="Kaiser I" first="Iris" last="Kaiser">Iris Kaiser</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurosurgery, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Beirer, Sebastian" sort="Beirer, Sebastian" uniqKey="Beirer S" first="Sebastian" last="Beirer">Sebastian Beirer</name><affiliation wicri:level="3"><nlm:affiliation>Wilhelminenspital, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Wilhelminenspital, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Sejio, Fernando" sort="Sejio, Fernando" uniqKey="Sejio F" first="Fernando" last="Sejio">Fernando Sejio</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Suarez, Esther" sort="Suarez, Esther" uniqKey="Suarez E" first="Esther" last="Suarez">Esther Suarez</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Lozano, Beatriz" sort="Lozano, Beatriz" uniqKey="Lozano B" first="Beatriz" last="Lozano">Beatriz Lozano</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitait du Rennes, Service de Neurochirurgie, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitait du Rennes, Service de Neurochirurgie, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name><affiliation wicri:level="3"><nlm:affiliation>Service de Neurologie, Hôpital Pontchaillou, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, Hôpital Pontchaillou, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Porta, Mauro" sort="Porta, Mauro" uniqKey="Porta M" first="Mauro" last="Porta">Mauro Porta</name><affiliation wicri:level="3"><nlm:affiliation>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Servello, Domenico" sort="Servello, Domenico" uniqKey="Servello D" first="Domenico" last="Servello">Domenico Servello</name><affiliation wicri:level="3"><nlm:affiliation>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Gill, Steven" sort="Gill, Steven" uniqKey="Gill S" first="Steven" last="Gill">Steven Gill</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery, Southmead Hospital, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurosurgery, Southmead Hospital, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Whone, Alan" sort="Whone, Alan" uniqKey="Whone A" first="Alan" last="Whone">Alan Whone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Southmead Hospital, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Southmead Hospital, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Van Dyck, Nic" sort="Van Dyck, Nic" uniqKey="Van Dyck N" first="Nic" last="Van Dyck">Nic Van Dyck</name><affiliation wicri:level="1"><nlm:affiliation>Boston Scientific, Neuromodulation, Maastricht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Boston Scientific, Neuromodulation, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Alesch, Francois" sort="Alesch, Francois" uniqKey="Alesch F" first="Francois" last="Alesch">Francois Alesch</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurosurgery, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Neurology</title><idno type="eISSN">1474-4465</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Deep Brain Stimulation (instrumentation)</term><term>Deep Brain Stimulation (methods)</term><term>Electrodes, Implanted</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (therapy)</term><term>Prospective Studies</term><term>Subthalamic Nucleus (physiology)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Electrodes, Implanted</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High-frequency deep brain stimulation (DBS) with a single electrical source is effective for motor symptom relief in patients with Parkinson's disease. We postulated that a multiple-source, constant-current device that permits well defined distribution of current would lead to motor improvement in patients with Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Californie</li><li>Lombardie</li><li>Région Bretagne</li><li>Vienne (Autriche)</li></region><settlement><li>Milan</li><li>Rennes</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></noRegion><name sortKey="Allert, Niels" sort="Allert, Niels" uniqKey="Allert N" first="Niels" last="Allert">Niels Allert</name><name sortKey="Barbe, Michael T" sort="Barbe, Michael T" uniqKey="Barbe M" first="Michael T" last="Barbe">Michael T. Barbe</name><name sortKey="Maarouf, Mohamed" sort="Maarouf, Mohamed" uniqKey="Maarouf M" first="Mohamed" last="Maarouf">Mohamed Maarouf</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Jain, Roshini" sort="Jain, Roshini" uniqKey="Jain R" first="Roshini" last="Jain">Roshini Jain</name></region><name sortKey="Chen, Lilly" sort="Chen, Lilly" uniqKey="Chen L" first="Lilly" last="Chen">Lilly Chen</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name></region><name sortKey="Alesch, Francois" sort="Alesch, Francois" uniqKey="Alesch F" first="Francois" last="Alesch">Francois Alesch</name><name sortKey="Beirer, Sebastian" sort="Beirer, Sebastian" uniqKey="Beirer S" first="Sebastian" last="Beirer">Sebastian Beirer</name><name sortKey="Kaiser, Iris" sort="Kaiser, Iris" uniqKey="Kaiser I" first="Iris" last="Kaiser">Iris Kaiser</name></country><country name="Espagne"><noRegion><name sortKey="Sejio, Fernando" sort="Sejio, Fernando" uniqKey="Sejio F" first="Fernando" last="Sejio">Fernando Sejio</name></noRegion><name sortKey="Lozano, Beatriz" sort="Lozano, Beatriz" uniqKey="Lozano B" first="Beatriz" last="Lozano">Beatriz Lozano</name><name sortKey="Suarez, Esther" sort="Suarez, Esther" uniqKey="Suarez E" first="Esther" last="Suarez">Esther Suarez</name></country><country name="France"><region name="Région Bretagne"><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name></region><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Porta, Mauro" sort="Porta, Mauro" uniqKey="Porta M" first="Mauro" last="Porta">Mauro Porta</name></region><name sortKey="Servello, Domenico" sort="Servello, Domenico" uniqKey="Servello D" first="Domenico" last="Servello">Domenico Servello</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Gill, Steven" sort="Gill, Steven" uniqKey="Gill S" first="Steven" last="Gill">Steven Gill</name></noRegion><name sortKey="Whone, Alan" sort="Whone, Alan" uniqKey="Whone A" first="Alan" last="Whone">Alan Whone</name></country><country name="Pays-Bas"><noRegion><name sortKey="Van Dyck, Nic" sort="Van Dyck, Nic" uniqKey="Van Dyck N" first="Nic" last="Van Dyck">Nic Van Dyck</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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