Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.
Identifieur interne : 000575 ( Main/Curation ); précédent : 000574; suivant : 000576Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.
Auteurs : Lars Timmermann [Allemagne] ; Roshini Jain [États-Unis] ; Lilly Chen [États-Unis] ; Mohamed Maarouf [Allemagne] ; Michael T. Barbe [Allemagne] ; Niels Allert [Allemagne] ; Thomas Brücke [Autriche] ; Iris Kaiser [Autriche] ; Sebastian Beirer [Autriche] ; Fernando Sejio [Espagne] ; Esther Suarez [Espagne] ; Beatriz Lozano [Espagne] ; Claire Haegelen [France] ; Marc Vérin [France] ; Mauro Porta [Italie] ; Domenico Servello [Italie] ; Steven Gill [Royaume-Uni] ; Alan Whone [Royaume-Uni] ; Nic Van Dyck [Pays-Bas] ; Francois Alesch [Autriche]Source :
- The Lancet. Neurology [ 1474-4465 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Parkinson Disease.
- instrumentation : Deep Brain Stimulation.
- methods : Deep Brain Stimulation.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Adult, Aged, Electrodes, Implanted, Female, Humans, Male, Middle Aged, Prospective Studies, Treatment Outcome.
Abstract
High-frequency deep brain stimulation (DBS) with a single electrical source is effective for motor symptom relief in patients with Parkinson's disease. We postulated that a multiple-source, constant-current device that permits well defined distribution of current would lead to motor improvement in patients with Parkinson's disease.
Url:
DOI: 10.1016/S1474-4422(15)00087-3
PubMed: 26027940
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pubmed:26027940Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.</title>
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<author><name sortKey="Lozano, Beatriz" sort="Lozano, Beatriz" uniqKey="Lozano B" first="Beatriz" last="Lozano">Beatriz Lozano</name>
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<author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name>
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<settlement type="city">Rennes</settlement>
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</affiliation>
</author>
<author><name sortKey="Porta, Mauro" sort="Porta, Mauro" uniqKey="Porta M" first="Mauro" last="Porta">Mauro Porta</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Servello, Domenico" sort="Servello, Domenico" uniqKey="Servello D" first="Domenico" last="Servello">Domenico Servello</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gill, Steven" sort="Gill, Steven" uniqKey="Gill S" first="Steven" last="Gill">Steven Gill</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery, Southmead Hospital, Bristol, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurosurgery, Southmead Hospital, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Whone, Alan" sort="Whone, Alan" uniqKey="Whone A" first="Alan" last="Whone">Alan Whone</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Southmead Hospital, Bristol, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurology, Southmead Hospital, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Dyck, Nic" sort="Van Dyck, Nic" uniqKey="Van Dyck N" first="Nic" last="Van Dyck">Nic Van Dyck</name>
<affiliation wicri:level="1"><nlm:affiliation>Boston Scientific, Neuromodulation, Maastricht, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Boston Scientific, Neuromodulation, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alesch, Francois" sort="Alesch, Francois" uniqKey="Alesch F" first="Francois" last="Alesch">Francois Alesch</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurosurgery, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Lancet. Neurology</title>
<idno type="eISSN">1474-4465</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Deep Brain Stimulation (instrumentation)</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Electrodes, Implanted</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (therapy)</term>
<term>Prospective Studies</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Deep Brain Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Electrodes, Implanted</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Treatment Outcome</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">High-frequency deep brain stimulation (DBS) with a single electrical source is effective for motor symptom relief in patients with Parkinson's disease. We postulated that a multiple-source, constant-current device that permits well defined distribution of current would lead to motor improvement in patients with Parkinson's disease.</div>
</front>
</TEI>
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