Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.
Identifieur interne : 000332 ( PubMed/Corpus ); précédent : 000331; suivant : 000333Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.
Auteurs : Lars Timmermann ; Roshini Jain ; Lilly Chen ; Mohamed Maarouf ; Michael T. Barbe ; Niels Allert ; Thomas Brücke ; Iris Kaiser ; Sebastian Beirer ; Fernando Sejio ; Esther Suarez ; Beatriz Lozano ; Claire Haegelen ; Marc Vérin ; Mauro Porta ; Domenico Servello ; Steven Gill ; Alan Whone ; Nic Van Dyck ; Francois AleschSource :
- The Lancet. Neurology [ 1474-4465 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Parkinson Disease.
- instrumentation : Deep Brain Stimulation.
- methods : Deep Brain Stimulation.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Adult, Aged, Electrodes, Implanted, Female, Humans, Male, Middle Aged, Prospective Studies, Treatment Outcome.
Abstract
High-frequency deep brain stimulation (DBS) with a single electrical source is effective for motor symptom relief in patients with Parkinson's disease. We postulated that a multiple-source, constant-current device that permits well defined distribution of current would lead to motor improvement in patients with Parkinson's disease.
DOI: 10.1016/S1474-4422(15)00087-3
PubMed: 26027940
Links to Exploration step
pubmed:26027940Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.</title><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation><nlm:affiliation>Department of Neurology, University Hospital Cologne, Cologne, Germany. Electronic address: lars.timmermann@uk-koeln.de.</nlm:affiliation></affiliation></author><author><name sortKey="Jain, Roshini" sort="Jain, Roshini" uniqKey="Jain R" first="Roshini" last="Jain">Roshini Jain</name><affiliation><nlm:affiliation>Boston Scientific, Neuromodulation, Valencia, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Lilly" sort="Chen, Lilly" uniqKey="Chen L" first="Lilly" last="Chen">Lilly Chen</name><affiliation><nlm:affiliation>Boston Scientific, Neuromodulation, Valencia, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Maarouf, Mohamed" sort="Maarouf, Mohamed" uniqKey="Maarouf M" first="Mohamed" last="Maarouf">Mohamed Maarouf</name><affiliation><nlm:affiliation>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Barbe, Michael T" sort="Barbe, Michael T" uniqKey="Barbe M" first="Michael T" last="Barbe">Michael T. Barbe</name><affiliation><nlm:affiliation>Department of Neurology, University Hospital Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Allert, Niels" sort="Allert, Niels" uniqKey="Allert N" first="Niels" last="Allert">Niels Allert</name><affiliation><nlm:affiliation>Neurological Rehabilitation Center, Godeshoehe, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name><affiliation><nlm:affiliation>Wilhelminenspital, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Kaiser, Iris" sort="Kaiser, Iris" uniqKey="Kaiser I" first="Iris" last="Kaiser">Iris Kaiser</name><affiliation><nlm:affiliation>Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Beirer, Sebastian" sort="Beirer, Sebastian" uniqKey="Beirer S" first="Sebastian" last="Beirer">Sebastian Beirer</name><affiliation><nlm:affiliation>Wilhelminenspital, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Sejio, Fernando" sort="Sejio, Fernando" uniqKey="Sejio F" first="Fernando" last="Sejio">Fernando Sejio</name><affiliation><nlm:affiliation>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Suarez, Esther" sort="Suarez, Esther" uniqKey="Suarez E" first="Esther" last="Suarez">Esther Suarez</name><affiliation><nlm:affiliation>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lozano, Beatriz" sort="Lozano, Beatriz" uniqKey="Lozano B" first="Beatriz" last="Lozano">Beatriz Lozano</name><affiliation><nlm:affiliation>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><affiliation><nlm:affiliation>Centre Hospitalier Universitait du Rennes, Service de Neurochirurgie, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name><affiliation><nlm:affiliation>Service de Neurologie, Hôpital Pontchaillou, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Porta, Mauro" sort="Porta, Mauro" uniqKey="Porta M" first="Mauro" last="Porta">Mauro Porta</name><affiliation><nlm:affiliation>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Servello, Domenico" sort="Servello, Domenico" uniqKey="Servello D" first="Domenico" last="Servello">Domenico Servello</name><affiliation><nlm:affiliation>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gill, Steven" sort="Gill, Steven" uniqKey="Gill S" first="Steven" last="Gill">Steven Gill</name><affiliation><nlm:affiliation>Department of Neurosurgery, Southmead Hospital, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Whone, Alan" sort="Whone, Alan" uniqKey="Whone A" first="Alan" last="Whone">Alan Whone</name><affiliation><nlm:affiliation>Department of Neurology, Southmead Hospital, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Van Dyck, Nic" sort="Van Dyck, Nic" uniqKey="Van Dyck N" first="Nic" last="Van Dyck">Nic Van Dyck</name><affiliation><nlm:affiliation>Boston Scientific, Neuromodulation, Maastricht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Alesch, Francois" sort="Alesch, Francois" uniqKey="Alesch F" first="Francois" last="Alesch">Francois Alesch</name><affiliation><nlm:affiliation>Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26027940</idno><idno type="pmid">26027940</idno><idno type="doi">10.1016/S1474-4422(15)00087-3</idno><idno type="wicri:Area/PubMed/Corpus">000332</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000332</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.</title><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation><nlm:affiliation>Department of Neurology, University Hospital Cologne, Cologne, Germany. Electronic address: lars.timmermann@uk-koeln.de.</nlm:affiliation></affiliation></author><author><name sortKey="Jain, Roshini" sort="Jain, Roshini" uniqKey="Jain R" first="Roshini" last="Jain">Roshini Jain</name><affiliation><nlm:affiliation>Boston Scientific, Neuromodulation, Valencia, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Lilly" sort="Chen, Lilly" uniqKey="Chen L" first="Lilly" last="Chen">Lilly Chen</name><affiliation><nlm:affiliation>Boston Scientific, Neuromodulation, Valencia, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Maarouf, Mohamed" sort="Maarouf, Mohamed" uniqKey="Maarouf M" first="Mohamed" last="Maarouf">Mohamed Maarouf</name><affiliation><nlm:affiliation>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Barbe, Michael T" sort="Barbe, Michael T" uniqKey="Barbe M" first="Michael T" last="Barbe">Michael T. Barbe</name><affiliation><nlm:affiliation>Department of Neurology, University Hospital Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Allert, Niels" sort="Allert, Niels" uniqKey="Allert N" first="Niels" last="Allert">Niels Allert</name><affiliation><nlm:affiliation>Neurological Rehabilitation Center, Godeshoehe, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name><affiliation><nlm:affiliation>Wilhelminenspital, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Kaiser, Iris" sort="Kaiser, Iris" uniqKey="Kaiser I" first="Iris" last="Kaiser">Iris Kaiser</name><affiliation><nlm:affiliation>Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Beirer, Sebastian" sort="Beirer, Sebastian" uniqKey="Beirer S" first="Sebastian" last="Beirer">Sebastian Beirer</name><affiliation><nlm:affiliation>Wilhelminenspital, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Sejio, Fernando" sort="Sejio, Fernando" uniqKey="Sejio F" first="Fernando" last="Sejio">Fernando Sejio</name><affiliation><nlm:affiliation>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Suarez, Esther" sort="Suarez, Esther" uniqKey="Suarez E" first="Esther" last="Suarez">Esther Suarez</name><affiliation><nlm:affiliation>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lozano, Beatriz" sort="Lozano, Beatriz" uniqKey="Lozano B" first="Beatriz" last="Lozano">Beatriz Lozano</name><affiliation><nlm:affiliation>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><affiliation><nlm:affiliation>Centre Hospitalier Universitait du Rennes, Service de Neurochirurgie, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name><affiliation><nlm:affiliation>Service de Neurologie, Hôpital Pontchaillou, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Porta, Mauro" sort="Porta, Mauro" uniqKey="Porta M" first="Mauro" last="Porta">Mauro Porta</name><affiliation><nlm:affiliation>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Servello, Domenico" sort="Servello, Domenico" uniqKey="Servello D" first="Domenico" last="Servello">Domenico Servello</name><affiliation><nlm:affiliation>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gill, Steven" sort="Gill, Steven" uniqKey="Gill S" first="Steven" last="Gill">Steven Gill</name><affiliation><nlm:affiliation>Department of Neurosurgery, Southmead Hospital, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Whone, Alan" sort="Whone, Alan" uniqKey="Whone A" first="Alan" last="Whone">Alan Whone</name><affiliation><nlm:affiliation>Department of Neurology, Southmead Hospital, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Van Dyck, Nic" sort="Van Dyck, Nic" uniqKey="Van Dyck N" first="Nic" last="Van Dyck">Nic Van Dyck</name><affiliation><nlm:affiliation>Boston Scientific, Neuromodulation, Maastricht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Alesch, Francois" sort="Alesch, Francois" uniqKey="Alesch F" first="Francois" last="Alesch">Francois Alesch</name><affiliation><nlm:affiliation>Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Lancet. Neurology</title><idno type="eISSN">1474-4465</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Deep Brain Stimulation (instrumentation)</term><term>Deep Brain Stimulation (methods)</term><term>Electrodes, Implanted</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (therapy)</term><term>Prospective Studies</term><term>Subthalamic Nucleus (physiology)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Electrodes, Implanted</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High-frequency deep brain stimulation (DBS) with a single electrical source is effective for motor symptom relief in patients with Parkinson's disease. We postulated that a multiple-source, constant-current device that permits well defined distribution of current would lead to motor improvement in patients with Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26027940</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>13</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>26</Day></DateCompleted><DateRevised><Year>2016</Year><Month>06</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-4465</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>7</Issue><PubDate><Year>2015</Year><Month>Jul</Month></PubDate></JournalIssue><Title>The Lancet. Neurology</Title><ISOAbbreviation>Lancet Neurol</ISOAbbreviation></Journal><ArticleTitle>Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.</ArticleTitle><Pagination><MedlinePgn>693-701</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/S1474-4422(15)00087-3</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1474-4422(15)00087-3</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">High-frequency deep brain stimulation (DBS) with a single electrical source is effective for motor symptom relief in patients with Parkinson's disease. We postulated that a multiple-source, constant-current device that permits well defined distribution of current would lead to motor improvement in patients with Parkinson's disease.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We did a prospective, multicentre, non-randomised, open-label intervention study of an implantable DBS device (the VANTAGE study) at six specialist DBS centres at universities in six European countries. Patients were judged eligible if they were aged 21-75 years, had been diagnosed with bilateral idiopathic Parkinson's disease with motor symptoms for more than 5 years, had a Hoehn and Yahr score of 2 or greater, and had a Unified Parkinson's disease rating scale part III (UPDRS III) score in the medication-off state of more than 30, which improved by 33% or more after a levodopa challenge. Participants underwent bilateral implantation in the subthalamic nucleus of a multiple-source, constant-current, eight-contact, rechargeable DBS system, and were assessed 12, 26, and 52 weeks after implantation. The primary endpoint was the mean change in UPDRS III scores (assessed by site investigators who were aware of the treatment assignment) from baseline (medication-off state) to 26 weeks after first lead implantation (stimulation-on, medication-off state). This study is registered with ClinicalTrials.gov, number NCT01221948.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Of 53 patients enrolled in the study, 40 received a bilateral implant in the subthalamic nucleus and their data contributed to the primary endpoint analysis. Improvement was noted in the UPDRS III motor score 6 months after first lead implantation (mean 13·5 [SD 6·8], 95% CI 11·3-15·7) compared with baseline (37·4 [8·9], 34·5-40·2), with a mean difference of 23·8 (SD 10·6; 95% CI 20·3-27·3; p<0·0001). One patient died of pneumonia 24 weeks after implantation, which was judged to be unrelated to the procedure. 125 adverse events were reported, the most frequent of which were dystonia, speech disorder, and apathy. 18 serious adverse events were recorded, three of which were attributed to the device or procedure (one case each of infection, migration, and respiratory depression). All serious adverse events resolved without residual effects and stimulation remained on during the study.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">The multiple-source, constant-current, eight-contact DBS system suppressed motor symptoms effectively in patients with Parkinson's disease, with an acceptable safety profile. Future trials are needed to investigate systematically the potential benefits of this system on postoperative outcome and its side-effects.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Boston Scientific.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Timmermann</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Hospital Cologne, Cologne, Germany. Electronic address: lars.timmermann@uk-koeln.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jain</LastName><ForeName>Roshini</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Boston Scientific, Neuromodulation, Valencia, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Lilly</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Boston Scientific, Neuromodulation, Valencia, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maarouf</LastName><ForeName>Mohamed</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barbe</LastName><ForeName>Michael T</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Hospital Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allert</LastName><ForeName>Niels</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Neurological Rehabilitation Center, Godeshoehe, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brücke</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Wilhelminenspital, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaiser</LastName><ForeName>Iris</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beirer</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Wilhelminenspital, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sejio</LastName><ForeName>Fernando</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suarez</LastName><ForeName>Esther</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lozano</LastName><ForeName>Beatriz</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Servicio de Neurocirugía, Instituto de Neurociencias, Hospital Universitario Central de Asturias, Oviedo, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haegelen</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre Hospitalier Universitait du Rennes, Service de Neurochirurgie, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vérin</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Service de Neurologie, Hôpital Pontchaillou, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Porta</LastName><ForeName>Mauro</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Servello</LastName><ForeName>Domenico</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Functional Neurosurgery, IRCCS Galeazzi Hospital, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gill</LastName><ForeName>Steven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Southmead Hospital, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whone</LastName><ForeName>Alan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Southmead Hospital, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Dyck</LastName><ForeName>Nic</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Boston Scientific, Neuromodulation, Maastricht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alesch</LastName><ForeName>Francois</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT01221948</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet Neurol</MedlineTA><NlmUniqueID>101139309</NlmUniqueID><ISSNLinking>1474-4422</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Lancet Neurol. 2015 Jul;14(7):670-1</RefSource><PMID Version="1">26027942</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046690" MajorTopicYN="N">Deep Brain Stimulation</DescriptorName><QualifierName UI="Q000295" MajorTopicYN="Y">instrumentation</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004567" MajorTopicYN="Y">Electrodes, Implanted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>11</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>04</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>05</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>6</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>6</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26027940</ArticleId><ArticleId IdType="pii">S1474-4422(15)00087-3</ArticleId><ArticleId IdType="doi">10.1016/S1474-4422(15)00087-3</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000332 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000332 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:26027940
|texte= Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:26027940" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |