ParkinsonFranceV1, Hal, Curation, bibRecord, 000769

Oxidative and nitrosative stress in Parkinson's disease

Identifieur interne : 000769 ( Hal/Curation ); précédent : 000768; suivant : 000770

Oxidative and nitrosative stress in Parkinson's disease

Auteurs : Anthony H. K. Tsang [Hong Kong] ; Kenny K. K. Chung [Hong Kong]

Source :

BBA - Molecular Basis of Disease [ 0925-4439 ] ; 2009-06-15.

RBID : Hal:hal-00562891

English descriptors

mix :
- Free radicals, Nitric oxide, Oxidative stress, Parkinson's disease, nitrosylation.

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder marked by movement impairment caused by a selective degeneration of dopaminergic neurons. The mechanism for dopaminergic neuronal degeneration in PD is not completely clear, but it is believed that oxidative and nitrosative stress plays an important role during the pathogenesis of PD. This notion is supported by various studies that several indices of oxidative and nitrosative stress are increased in PD patients. In recent years, different pathways that are known to be important for neuronal survival have been shown to be affected by oxidative and nitrosative stress. Apart from the well-known oxidative free radicals induced protein nitration, lipid peroxidation and DNA damage, increasing evidence also suggests that some neuroprotective pathways can be affected by nitric oxide through -nitrosylation. In addition, the selective dopaminergic neurodegeneration suggests that generation of oxidative stress associated with the metabolism of dopamine is an important contributor. Thorough understanding of how oxidative stress can contribute to the pathogenesis of PD will help formulate potential therapy for the treatment of this neurodegenerative disorder in the future.

Url:

https://hal.archives-ouvertes.fr/hal-00562891

DOI: 10.1016/j.bbadis.2008.12.006

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to stream Hal, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000841

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Hal:hal-00562891

Le document en format XML

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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a common neurodegenerative disorder marked by movement impairment caused by a selective degeneration of dopaminergic neurons. The mechanism for dopaminergic neuronal degeneration in PD is not completely clear, but it is believed that oxidative and nitrosative stress plays an important role during the pathogenesis of PD. This notion is supported by various studies that several indices of oxidative and nitrosative stress are increased in PD patients. In recent years, different pathways that are known to be important for neuronal survival have been shown to be affected by oxidative and nitrosative stress. Apart from the well-known oxidative free radicals induced protein nitration, lipid peroxidation and DNA damage, increasing evidence also suggests that some neuroprotective pathways can be affected by nitric oxide through -nitrosylation. In addition, the selective dopaminergic neurodegeneration suggests that generation of oxidative stress associated with the metabolism of dopamine is an important contributor. Thorough understanding of how oxidative stress can contribute to the pathogenesis of PD will help formulate potential therapy for the treatment of this neurodegenerative disorder in the future.</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Oxidative and nitrosative stress in Parkinson's disease

Oxidative and nitrosative stress in Parkinson's disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri