ParkinsonFranceV1, Main, Curation, bibRecord, 003488

Parkinson's disease and sleepiness: An integral part of PD

Identifieur interne : 003488 ( Main/Curation ); précédent : 003487; suivant : 003489

Parkinson's disease and sleepiness: An integral part of PD

Auteurs : I. Arnulf [France] ; E. Konofal [France] ; M. Merino-Andreu [France] ; J. L. Houeto [France] ; V. Mesnage [France] ; M. L. Welter [France] ; L. Lacomblez [France] ; J. L. Golmard [France] ; J. P. Derenne [France] ; Yves Agid [France]

Source :

Neurology [ 0028-3878 ] ; 2002.

RBID : Pascal:02-0298578

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Somnolence, Trouble sommeil, Etiologie, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Antiparkinson Agents (therapeutic use), Etiology, Female, Human, Humans, Male, Middle Aged, Multivariate Analysis, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson disease, Prospective Studies, Sleep Deprivation (complications), Sleep Deprivation (diagnosis), Sleep Wake Disorders (complications), Sleep Wake Disorders (diagnosis), Sleep disorder, Somnolence.
MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- complications : Parkinson Disease, Sleep Deprivation, Sleep Wake Disorders.
- diagnosis : Sleep Deprivation, Sleep Wake Disorders.
- drug therapy : Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Multivariate Analysis, Prospective Studies.

Abstract

Objective: To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents. Methods: The authors performed night-time polysomnography and daytime multiple sleep latency tests in 54 consecutive levodopa-treated patients with PD referred for sleepiness, 27 of whom were also receiving dopaminergic agonists. Results: Sleep latency was 6.3 ± 0.6 minutes (normal >8 minutes), and the Epworth Sleepiness score was 14.3 ± 4.1 (normal <10). A narcolepsy-like phenotype (≥2 sleep-onset REM periods) was found in 39% of the patients, who were sleepier (4.6 ± 0.9 minutes) than the other 61% of patients (7.4 ± 0.7 minutes). Periodic leg movement syndromes were rare (15%, range 16 to 43/h), but obstructive sleep apnea-hypopnea syndromes were frequent (20% of patients had an apnea-hypopnea index >15/h; range 15.1 to 50.0). Severity of sleepiness was weakly correlated with Epworth Sleepiness score (r = -0.34) and daily dose of levodopa (r = 0.30) but not with dopamine-agonist treatment, age, disease duration, parkinsonian motor disability, total sleep time, periodic leg movement, apnea-hypopnea, or arousal indices. Conclusions: In patients with PD preselected for sleepiness, severity of sleepiness was not dependent on nocturnal sleep abnormalities, motor and cognitive impairment, or antiparkinsonian treatment. The results suggest that sleepiness-sudden onset of sleep-does not result from pharmacotherapy but is related to the pathology of PD.

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Le document en format XML

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<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson disease</term>
<term>Prospective Studies</term>
<term>Sleep Deprivation (complications)</term>
<term>Sleep Deprivation (diagnosis)</term>
<term>Sleep Wake Disorders (complications)</term>
<term>Sleep Wake Disorders (diagnosis)</term>
<term>Sleep disorder</term>
<term>Somnolence</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
<term>Sleep Deprivation</term>
<term>Sleep Wake Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Sleep Deprivation</term>
<term>Sleep Wake Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Prospective Studies</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Somnolence</term>
<term>Trouble sommeil</term>
<term>Etiologie</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">Objective: To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents. Methods: The authors performed night-time polysomnography and daytime multiple sleep latency tests in 54 consecutive levodopa-treated patients with PD referred for sleepiness, 27 of whom were also receiving dopaminergic agonists. Results: Sleep latency was 6.3 ± 0.6 minutes (normal >8 minutes), and the Epworth Sleepiness score was 14.3 ± 4.1 (normal <10). A narcolepsy-like phenotype (≥2 sleep-onset REM periods) was found in 39% of the patients, who were sleepier (4.6 ± 0.9 minutes) than the other 61% of patients (7.4 ± 0.7 minutes). Periodic leg movement syndromes were rare (15%, range 16 to 43/h), but obstructive sleep apnea-hypopnea syndromes were frequent (20% of patients had an apnea-hypopnea index >15/h; range 15.1 to 50.0). Severity of sleepiness was weakly correlated with Epworth Sleepiness score (r = -0.34) and daily dose of levodopa (r = 0.30) but not with dopamine-agonist treatment, age, disease duration, parkinsonian motor disability, total sleep time, periodic leg movement, apnea-hypopnea, or arousal indices. Conclusions: In patients with PD preselected for sleepiness, severity of sleepiness was not dependent on nocturnal sleep abnormalities, motor and cognitive impairment, or antiparkinsonian treatment. The results suggest that sleepiness-sudden onset of sleep-does not result from pharmacotherapy but is related to the pathology of PD.</div>
</front>
</TEI>
<double idat="0028-3878:2002:Arnulf I:parkinson:s:disease"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Parkinson's disease and sleepiness: An integral part of PD</title>
<author><name sortKey="Arnulf, I" sort="Arnulf, I" uniqKey="Arnulf I" first="I." last="Arnulf">I. Arnulf</name>
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<wicri:noRegion>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris</wicri:noRegion>
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</author>
<author><name sortKey="Konofal, E" sort="Konofal, E" uniqKey="Konofal E" first="E." last="Konofal">E. Konofal</name>
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<author><name sortKey="Merino Andreu, M" sort="Merino Andreu, M" uniqKey="Merino Andreu M" first="M." last="Merino-Andreu">M. Merino-Andreu</name>
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<author><name sortKey="Houeto, J L" sort="Houeto, J L" uniqKey="Houeto J" first="J. L." last="Houeto">J. L. Houeto</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'Investigation Clinique, Fédération de Neurologie and Inserm U289, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris</s1>
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<date when="2002">2002</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Parkinson's disease and sleepiness: An integral part of PD</title>
<author><name sortKey="Arnulf, I" sort="Arnulf, I" uniqKey="Arnulf I" first="I." last="Arnulf">I. Arnulf</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris</s1>
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<wicri:noRegion>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Konofal, E" sort="Konofal, E" uniqKey="Konofal E" first="E." last="Konofal">E. Konofal</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris</s1>
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</affiliation>
</author>
<author><name sortKey="Merino Andreu, M" sort="Merino Andreu, M" uniqKey="Merino Andreu M" first="M." last="Merino-Andreu">M. Merino-Andreu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris</s1>
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</affiliation>
</author>
<author><name sortKey="Houeto, J L" sort="Houeto, J L" uniqKey="Houeto J" first="J. L." last="Houeto">J. L. Houeto</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'Investigation Clinique, Fédération de Neurologie and Inserm U289, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris</s1>
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<author><name sortKey="Mesnage, V" sort="Mesnage, V" uniqKey="Mesnage V" first="V." last="Mesnage">V. Mesnage</name>
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<author><name sortKey="Welter, M L" sort="Welter, M L" uniqKey="Welter M" first="M. L." last="Welter">M. L. Welter</name>
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<author><name sortKey="Lacomblez, L" sort="Lacomblez, L" uniqKey="Lacomblez L" first="L." last="Lacomblez">L. Lacomblez</name>
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<author><name sortKey="Golmard, J L" sort="Golmard, J L" uniqKey="Golmard J" first="J. L." last="Golmard">J. L. Golmard</name>
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<author><name sortKey="Derenne, J P" sort="Derenne, J P" uniqKey="Derenne J" first="J. P." last="Derenne">J. P. Derenne</name>
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<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'Investigation Clinique, Fédération de Neurologie and Inserm U289, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris</s1>
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<region type="region" nuts="2">Île-de-France</region>
</placeName>
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</analytic>
<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2002">2002</date>
</imprint>
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<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Etiology</term>
<term>Human</term>
<term>Parkinson disease</term>
<term>Sleep disorder</term>
<term>Somnolence</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Somnolence</term>
<term>Trouble sommeil</term>
<term>Etiologie</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">Objective: To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents. Methods: The authors performed night-time polysomnography and daytime multiple sleep latency tests in 54 consecutive levodopa-treated patients with PD referred for sleepiness, 27 of whom were also receiving dopaminergic agonists. Results: Sleep latency was 6.3 ± 0.6 minutes (normal >8 minutes), and the Epworth Sleepiness score was 14.3 ± 4.1 (normal <10). A narcolepsy-like phenotype (≥2 sleep-onset REM periods) was found in 39% of the patients, who were sleepier (4.6 ± 0.9 minutes) than the other 61% of patients (7.4 ± 0.7 minutes). Periodic leg movement syndromes were rare (15%, range 16 to 43/h), but obstructive sleep apnea-hypopnea syndromes were frequent (20% of patients had an apnea-hypopnea index >15/h; range 15.1 to 50.0). Severity of sleepiness was weakly correlated with Epworth Sleepiness score (r = -0.34) and daily dose of levodopa (r = 0.30) but not with dopamine-agonist treatment, age, disease duration, parkinsonian motor disability, total sleep time, periodic leg movement, apnea-hypopnea, or arousal indices. Conclusions: In patients with PD preselected for sleepiness, severity of sleepiness was not dependent on nocturnal sleep abnormalities, motor and cognitive impairment, or antiparkinsonian treatment. The results suggest that sleepiness-sudden onset of sleep-does not result from pharmacotherapy but is related to the pathology of PD.</div>
</front>
</TEI>
</INIST>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinson's disease and sleepiness: an integral part of PD.</title>
<author><name sortKey="Arnulf, I" sort="Arnulf, I" uniqKey="Arnulf I" first="I" last="Arnulf">I. Arnulf</name>
<affiliation wicri:level="1"><nlm:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, France. isabelle.arnulf@psl.ap-hop-paris.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris</wicri:regionArea>
<wicri:noRegion>Assistance Publique-Hôpitaux de Paris</wicri:noRegion>
<wicri:noRegion>Assistance Publique-Hôpitaux de Paris</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Konofal, E" sort="Konofal, E" uniqKey="Konofal E" first="E" last="Konofal">E. Konofal</name>
</author>
<author><name sortKey="Merino Andreu, M" sort="Merino Andreu, M" uniqKey="Merino Andreu M" first="M" last="Merino-Andreu">M. Merino-Andreu</name>
</author>
<author><name sortKey="Houeto, J L" sort="Houeto, J L" uniqKey="Houeto J" first="J L" last="Houeto">J L Houeto</name>
</author>
<author><name sortKey="Mesnage, V" sort="Mesnage, V" uniqKey="Mesnage V" first="V" last="Mesnage">V. Mesnage</name>
</author>
<author><name sortKey="Welter, M L" sort="Welter, M L" uniqKey="Welter M" first="M L" last="Welter">M L Welter</name>
</author>
<author><name sortKey="Lacomblez, L" sort="Lacomblez, L" uniqKey="Lacomblez L" first="L" last="Lacomblez">L. Lacomblez</name>
</author>
<author><name sortKey="Golmard, J L" sort="Golmard, J L" uniqKey="Golmard J" first="J L" last="Golmard">J L Golmard</name>
</author>
<author><name sortKey="Derenne, J P" sort="Derenne, J P" uniqKey="Derenne J" first="J P" last="Derenne">J P Derenne</name>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2002">2002</date>
<idno type="RBID">pubmed:11940685</idno>
<idno type="pmid">11940685</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Parkinson's disease and sleepiness: an integral part of PD.</title>
<author><name sortKey="Arnulf, I" sort="Arnulf, I" uniqKey="Arnulf I" first="I" last="Arnulf">I. Arnulf</name>
<affiliation wicri:level="1"><nlm:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, France. isabelle.arnulf@psl.ap-hop-paris.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris</wicri:regionArea>
<wicri:noRegion>Assistance Publique-Hôpitaux de Paris</wicri:noRegion>
<wicri:noRegion>Assistance Publique-Hôpitaux de Paris</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Konofal, E" sort="Konofal, E" uniqKey="Konofal E" first="E" last="Konofal">E. Konofal</name>
</author>
<author><name sortKey="Merino Andreu, M" sort="Merino Andreu, M" uniqKey="Merino Andreu M" first="M" last="Merino-Andreu">M. Merino-Andreu</name>
</author>
<author><name sortKey="Houeto, J L" sort="Houeto, J L" uniqKey="Houeto J" first="J L" last="Houeto">J L Houeto</name>
</author>
<author><name sortKey="Mesnage, V" sort="Mesnage, V" uniqKey="Mesnage V" first="V" last="Mesnage">V. Mesnage</name>
</author>
<author><name sortKey="Welter, M L" sort="Welter, M L" uniqKey="Welter M" first="M L" last="Welter">M L Welter</name>
</author>
<author><name sortKey="Lacomblez, L" sort="Lacomblez, L" uniqKey="Lacomblez L" first="L" last="Lacomblez">L. Lacomblez</name>
</author>
<author><name sortKey="Golmard, J L" sort="Golmard, J L" uniqKey="Golmard J" first="J L" last="Golmard">J L Golmard</name>
</author>
<author><name sortKey="Derenne, J P" sort="Derenne, J P" uniqKey="Derenne J" first="J P" last="Derenne">J P Derenne</name>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2002" type="published">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Prospective Studies</term>
<term>Sleep Deprivation (complications)</term>
<term>Sleep Deprivation (diagnosis)</term>
<term>Sleep Wake Disorders (complications)</term>
<term>Sleep Wake Disorders (diagnosis)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
<term>Sleep Deprivation</term>
<term>Sleep Wake Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Sleep Deprivation</term>
<term>Sleep Wake Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Prospective Studies</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents.</div>
</front>
</TEI>
</PubMed>
</double>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Parkinson's disease and sleepiness: An integral part of PD

Parkinson's disease and sleepiness: An integral part of PD

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