ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 001116

Parkinson's disease and sleepiness: An integral part of PD

Identifieur interne : 001116 ( PascalFrancis/Corpus ); précédent : 001115; suivant : 001117

Parkinson's disease and sleepiness: An integral part of PD

Auteurs : I. Arnulf ; E. Konofal ; M. Merino-Andreu ; J. L. Houeto ; V. Mesnage ; M. L. Welter ; L. Lacomblez ; J. L. Golmard ; J. P. Derenne ; Y. Agid

Source :

Neurology [ 0028-3878 ] ; 2002.

RBID : Pascal:02-0298578

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Somnolence, Trouble sommeil, Etiologie, Homme.

English descriptors

KwdEn :
- Etiology, Human, Parkinson disease, Sleep disorder, Somnolence.

Abstract

Objective: To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents. Methods: The authors performed night-time polysomnography and daytime multiple sleep latency tests in 54 consecutive levodopa-treated patients with PD referred for sleepiness, 27 of whom were also receiving dopaminergic agonists. Results: Sleep latency was 6.3 ± 0.6 minutes (normal >8 minutes), and the Epworth Sleepiness score was 14.3 ± 4.1 (normal <10). A narcolepsy-like phenotype (≥2 sleep-onset REM periods) was found in 39% of the patients, who were sleepier (4.6 ± 0.9 minutes) than the other 61% of patients (7.4 ± 0.7 minutes). Periodic leg movement syndromes were rare (15%, range 16 to 43/h), but obstructive sleep apnea-hypopnea syndromes were frequent (20% of patients had an apnea-hypopnea index >15/h; range 15.1 to 50.0). Severity of sleepiness was weakly correlated with Epworth Sleepiness score (r = -0.34) and daily dose of levodopa (r = 0.30) but not with dopamine-agonist treatment, age, disease duration, parkinsonian motor disability, total sleep time, periodic leg movement, apnea-hypopnea, or arousal indices. Conclusions: In patients with PD preselected for sleepiness, severity of sleepiness was not dependent on nocturnal sleep abnormalities, motor and cognitive impairment, or antiparkinsonian treatment. The results suggest that sleepiness-sudden onset of sleep-does not result from pharmacotherapy but is related to the pathology of PD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 ARNULF (I.)`
A11	`02`	`1`		`@1 KONOFAL (E.)`
A11	`03`	`1`		`@1 MERINO-ANDREU (M.)`
A11	`04`	`1`		`@1 HOUETO (J. L.)`
A11	`05`	`1`		`@1 MESNAGE (V.)`
A11	`06`	`1`		`@1 WELTER (M. L.)`
A11	`07`	`1`		`@1 LACOMBLEZ (L.)`
A11	`08`	`1`		`@1 GOLMARD (J. L.)`
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A14	`02`			`@1 Centre d'Investigation Clinique, Fédération de Neurologie and Inserm U289, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris @3 FRA @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 10 aut.`
A14	`03`			`@1 Service de Neuropharmacologie, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris @3 FRA @Z 7 aut.`
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A44				`@0 0000 @1 © 2002 INIST-CNRS. All rights reserved.`
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A47	`01`	`1`		`@0 02-0298578`
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A61				`@0 A`
A64	`01`	`1`		`@0 Neurology`
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C01	`01`		`ENG`	@0 Objective: To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents. Methods: The authors performed night-time polysomnography and daytime multiple sleep latency tests in 54 consecutive levodopa-treated patients with PD referred for sleepiness, 27 of whom were also receiving dopaminergic agonists. Results: Sleep latency was 6.3 ± 0.6 minutes (normal >8 minutes), and the Epworth Sleepiness score was 14.3 ± 4.1 (normal <10). A narcolepsy-like phenotype (≥2 sleep-onset REM periods) was found in 39% of the patients, who were sleepier (4.6 ± 0.9 minutes) than the other 61% of patients (7.4 ± 0.7 minutes). Periodic leg movement syndromes were rare (15%, range 16 to 43/h), but obstructive sleep apnea-hypopnea syndromes were frequent (20% of patients had an apnea-hypopnea index >15/h; range 15.1 to 50.0). Severity of sleepiness was weakly correlated with Epworth Sleepiness score (r = -0.34) and daily dose of levodopa (r = 0.30) but not with dopamine-agonist treatment, age, disease duration, parkinsonian motor disability, total sleep time, periodic leg movement, apnea-hypopnea, or arousal indices. Conclusions: In patients with PD preselected for sleepiness, severity of sleepiness was not dependent on nocturnal sleep abnormalities, motor and cognitive impairment, or antiparkinsonian treatment. The results suggest that sleepiness-sudden onset of sleep-does not result from pharmacotherapy but is related to the pathology of PD.
C02	`01`	`X`		`@0 002B17G`
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C03	`01`	`X`	`ENG`	`@0 Parkinson disease @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @5 01`
C03	`02`	`X`	`FRE`	`@0 Somnolence @5 04`
C03	`02`	`X`	`ENG`	`@0 Somnolence @5 04`
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C03	`03`	`X`	`SPA`	`@0 Trastorno sueño @5 07`
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C03	`04`	`X`	`ENG`	`@0 Etiology @5 17`
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C03	`05`	`X`	`FRE`	`@0 Homme @5 20`
C03	`05`	`X`	`ENG`	`@0 Human @5 20`
C03	`05`	`X`	`SPA`	`@0 Hombre @5 20`
C07	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 37`
C07	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 38`
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C07	`02`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Encéphale pathologie @5 39`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
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C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
C07	`06`	`X`	`FRE`	`@0 Trouble neurologique @5 54`
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N21				`@1 169`
N82				`@1 PSI`

Format Inist (serveur)

NO :	PASCAL 02-0298578 INIST
ET :	Parkinson's disease and sleepiness: An integral part of PD
AU :	ARNULF (I.); KONOFAL (E.); MERINO-ANDREU (M.); HOUETO (J. L.); MESNAGE (V.); WELTER (M. L.); LACOMBLEZ (L.); GOLMARD (J. L.); DERENNE (J. P.); AGID (Y.)
AF :	Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris/France (1 aut., 2 aut., 3 aut., 9 aut.); Centre d'Investigation Clinique, Fédération de Neurologie and Inserm U289, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris/France (4 aut., 5 aut., 6 aut., 10 aut.); Service de Neuropharmacologie, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris/France (7 aut.); Service d'Informatique Médicale, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris/France (8 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2002; Vol. 58; No. 7; Pp. 1019-1024; Bibl. 27 ref.
LA :	Anglais
EA :	Objective: To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents. Methods: The authors performed night-time polysomnography and daytime multiple sleep latency tests in 54 consecutive levodopa-treated patients with PD referred for sleepiness, 27 of whom were also receiving dopaminergic agonists. Results: Sleep latency was 6.3 ± 0.6 minutes (normal >8 minutes), and the Epworth Sleepiness score was 14.3 ± 4.1 (normal <10). A narcolepsy-like phenotype (≥2 sleep-onset REM periods) was found in 39% of the patients, who were sleepier (4.6 ± 0.9 minutes) than the other 61% of patients (7.4 ± 0.7 minutes). Periodic leg movement syndromes were rare (15%, range 16 to 43/h), but obstructive sleep apnea-hypopnea syndromes were frequent (20% of patients had an apnea-hypopnea index >15/h; range 15.1 to 50.0). Severity of sleepiness was weakly correlated with Epworth Sleepiness score (r = -0.34) and daily dose of levodopa (r = 0.30) but not with dopamine-agonist treatment, age, disease duration, parkinsonian motor disability, total sleep time, periodic leg movement, apnea-hypopnea, or arousal indices. Conclusions: In patients with PD preselected for sleepiness, severity of sleepiness was not dependent on nocturnal sleep abnormalities, motor and cognitive impairment, or antiparkinsonian treatment. The results suggest that sleepiness-sudden onset of sleep-does not result from pharmacotherapy but is related to the pathology of PD.
CC :	002B17G
FD :	Parkinson maladie; Somnolence; Trouble sommeil; Etiologie; Homme
FG :	Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Trouble neurologique
ED :	Parkinson disease; Somnolence; Sleep disorder; Etiology; Human
EG :	Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Neurological disorder
SD :	Parkinson enfermedad; Somnolencia; Trastorno sueño; Etiología; Hombre
LO :	INIST-6345.354000107955740060
ID :	02-0298578

Links to Exploration step

Pascal:02-0298578

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Etiology</term>
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<front><div type="abstract" xml:lang="en">Objective: To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents. Methods: The authors performed night-time polysomnography and daytime multiple sleep latency tests in 54 consecutive levodopa-treated patients with PD referred for sleepiness, 27 of whom were also receiving dopaminergic agonists. Results: Sleep latency was 6.3 ± 0.6 minutes (normal >8 minutes), and the Epworth Sleepiness score was 14.3 ± 4.1 (normal <10). A narcolepsy-like phenotype (≥2 sleep-onset REM periods) was found in 39% of the patients, who were sleepier (4.6 ± 0.9 minutes) than the other 61% of patients (7.4 ± 0.7 minutes). Periodic leg movement syndromes were rare (15%, range 16 to 43/h), but obstructive sleep apnea-hypopnea syndromes were frequent (20% of patients had an apnea-hypopnea index >15/h; range 15.1 to 50.0). Severity of sleepiness was weakly correlated with Epworth Sleepiness score (r = -0.34) and daily dose of levodopa (r = 0.30) but not with dopamine-agonist treatment, age, disease duration, parkinsonian motor disability, total sleep time, periodic leg movement, apnea-hypopnea, or arousal indices. Conclusions: In patients with PD preselected for sleepiness, severity of sleepiness was not dependent on nocturnal sleep abnormalities, motor and cognitive impairment, or antiparkinsonian treatment. The results suggest that sleepiness-sudden onset of sleep-does not result from pharmacotherapy but is related to the pathology of PD.</div>
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<s5>40</s5>
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<server><NO>PASCAL 02-0298578 INIST</NO>
<ET>Parkinson's disease and sleepiness: An integral part of PD</ET>
<AU>ARNULF (I.); KONOFAL (E.); MERINO-ANDREU (M.); HOUETO (J. L.); MESNAGE (V.); WELTER (M. L.); LACOMBLEZ (L.); GOLMARD (J. L.); DERENNE (J. P.); AGID (Y.)</AU>
<AF>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris/France (1 aut., 2 aut., 3 aut., 9 aut.); Centre d'Investigation Clinique, Fédération de Neurologie and Inserm U289, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris/France (4 aut., 5 aut., 6 aut., 10 aut.); Service de Neuropharmacologie, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris/France (7 aut.); Service d'Informatique Médicale, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris/France (8 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2002; Vol. 58; No. 7; Pp. 1019-1024; Bibl. 27 ref.</SO>
<LA>Anglais</LA>
<EA>Objective: To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents. Methods: The authors performed night-time polysomnography and daytime multiple sleep latency tests in 54 consecutive levodopa-treated patients with PD referred for sleepiness, 27 of whom were also receiving dopaminergic agonists. Results: Sleep latency was 6.3 ± 0.6 minutes (normal >8 minutes), and the Epworth Sleepiness score was 14.3 ± 4.1 (normal <10). A narcolepsy-like phenotype (≥2 sleep-onset REM periods) was found in 39% of the patients, who were sleepier (4.6 ± 0.9 minutes) than the other 61% of patients (7.4 ± 0.7 minutes). Periodic leg movement syndromes were rare (15%, range 16 to 43/h), but obstructive sleep apnea-hypopnea syndromes were frequent (20% of patients had an apnea-hypopnea index >15/h; range 15.1 to 50.0). Severity of sleepiness was weakly correlated with Epworth Sleepiness score (r = -0.34) and daily dose of levodopa (r = 0.30) but not with dopamine-agonist treatment, age, disease duration, parkinsonian motor disability, total sleep time, periodic leg movement, apnea-hypopnea, or arousal indices. Conclusions: In patients with PD preselected for sleepiness, severity of sleepiness was not dependent on nocturnal sleep abnormalities, motor and cognitive impairment, or antiparkinsonian treatment. The results suggest that sleepiness-sudden onset of sleep-does not result from pharmacotherapy but is related to the pathology of PD.</EA>
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<ED>Parkinson disease; Somnolence; Sleep disorder; Etiology; Human</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Neurological disorder</EG>
<SD>Parkinson enfermedad; Somnolencia; Trastorno sueño; Etiología; Hombre</SD>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Parkinson's disease and sleepiness: An integral part of PD

Parkinson's disease and sleepiness: An integral part of PD

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