Parkinson's disease and sleepiness: an integral part of PD.
Identifieur interne : 000234 ( Ncbi/Merge ); précédent : 000233; suivant : 000235Parkinson's disease and sleepiness: an integral part of PD.
Auteurs : I. Arnulf [France] ; E. Konofal ; M. Merino-Andreu ; J L Houeto ; V. Mesnage ; M L Welter ; L. Lacomblez ; J L Golmard ; J P Derenne ; Yves Agid [France]Source :
- Neurology [ 0028-3878 ] ; 2002.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antiparkinson Agents (therapeutic use), Female, Humans, Male, Middle Aged, Multivariate Analysis, Parkinson Disease (complications), Parkinson Disease (drug therapy), Prospective Studies, Sleep Deprivation (complications), Sleep Deprivation (diagnosis), Sleep Wake Disorders (complications), Sleep Wake Disorders (diagnosis).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- complications : Parkinson Disease, Sleep Deprivation, Sleep Wake Disorders.
- diagnosis : Sleep Deprivation, Sleep Wake Disorders.
- drug therapy : Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Multivariate Analysis, Prospective Studies.
Abstract
To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents.
PubMed: 11940685
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001196
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- to stream PubMed, to step Checkpoint: 001155
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pubmed:11940685Le document en format XML
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<front><div type="abstract" xml:lang="en">To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11940685</PMID>
<DateCreated><Year>2002</Year>
<Month>04</Month>
<Day>09</Day>
</DateCreated>
<DateCompleted><Year>2002</Year>
<Month>05</Month>
<Day>07</Day>
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<Month>11</Month>
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<Day>09</Day>
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<Title>Neurology</Title>
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<ArticleTitle>Parkinson's disease and sleepiness: an integral part of PD.</ArticleTitle>
<Pagination><MedlinePgn>1019-24</MedlinePgn>
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<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The authors performed night-time polysomnography and daytime multiple sleep latency tests in 54 consecutive levodopa-treated patients with PD referred for sleepiness, 27 of whom were also receiving dopaminergic agonists.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Sleep latency was 6.3 +/- 0.6 minutes (normal >8 minutes), and the Epworth Sleepiness score was 14.3 +/- 4.1 (normal <10). A narcolepsy-like phenotype (> or = 2 sleep-onset REM periods) was found in 39% of the patients, who were sleepier (4.6 +/- 0.9 minutes) than the other 61% of patients (7.4 +/- 0.7 minutes). Periodic leg movement syndromes were rare (15%, range 16 to 43/h), but obstructive sleep apnea-hypopnea syndromes were frequent (20% of patients had an apnea-hypopnea index >15/h; range 15.1 to 50.0). Severity of sleepiness was weakly correlated with Epworth Sleepiness score (r = -0.34) and daily dose of levodopa (r = 0.30) but not with dopamine-agonist treatment, age, disease duration, parkinsonian motor disability, total sleep time, periodic leg movement, apnea-hypopnea, or arousal indices.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In patients with PD preselected for sleepiness, severity of sleepiness was not dependent on nocturnal sleep abnormalities, motor and cognitive impairment, or antiparkinsonian treatment. The results suggest that sleepiness-sudden onset of sleep-does not result from pharmacotherapy but is related to the pathology of PD.</AbstractText>
</Abstract>
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