Nonmotor fluctuations in Parkinson's disease: Frequent and disabling
Identifieur interne : 003489 ( Main/Curation ); précédent : 003488; suivant : 003490Nonmotor fluctuations in Parkinson's disease: Frequent and disabling
Auteurs : T. Witjas [France] ; E. Kaphan [France] ; J. P. Azulay [France] ; O. Blin [France] ; M. Ceccaldi [France] ; J. Pouget [France] ; M. Poncet [France] ; A. Ali Cherif [France]Source :
- Neurology [ 0028-3878 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Autonomic Nervous System Diseases (epidemiology), Autonomic Nervous System Diseases (physiopathology), Autonomic Nervous System Diseases (psychology), Chi-Square Distribution, Cognition Disorders (epidemiology), Cognition Disorders (physiopathology), Cognition Disorders (psychology), Female, Fluctuations, Frequency, Handicap, Human, Humans, Male, Middle Aged, Parkinson Disease (epidemiology), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson disease, Prospective Studies, Questionnaire, Sensation Disorders (epidemiology), Sensation Disorders (physiopathology), Sensation Disorders (psychology), Statistics, Nonparametric, Surveys and Questionnaires, Symptomatology.
- MESH :
- epidemiology : Autonomic Nervous System Diseases, Cognition Disorders, Parkinson Disease, Sensation Disorders.
- physiopathology : Autonomic Nervous System Diseases, Cognition Disorders, Parkinson Disease, Sensation Disorders.
- psychology : Autonomic Nervous System Diseases, Cognition Disorders, Parkinson Disease, Sensation Disorders.
- Aged, Chi-Square Distribution, Female, Humans, Male, Middle Aged, Prospective Studies, Statistics, Nonparametric, Surveys and Questionnaires.
Abstract
Objective: To assess the frequency and disability caused by nonmotor fluctuations (NMF) in PD. Methods: A structured questionnaire was administered to 50 patients with PD with motor fluctuations (MF), focused on 54 nonmotor symptoms classified in three subgroups: 26 dysautonomic, 21 cognitive and psychiatric, and seven pain/sensory NMF. The link between each NMF and the motor state was determined. Patients were asked to grade their disability from 0 (no disability) to 4 (maximum discomfort) and to specify which kind of fluctuation subgroup (motor or nonmotor) was the most incapacitating. A statistical analysis was performed to determine the frequency of each NMF and to determine whether the level of disability resulting from NMF could be correlated to the main characteristics of the population. Results: All patients had had at least one type of NMF, most of which were associated with the "off" state. Anxiety (66%), drenching sweats (64%), slowness of thinking (58%), fatigue (56%), and akathisia (54%) were the most frequent NMF. Some symptoms such as anxiety or dyspnea correlated with a greater level of disability. The total number of NMF was found to be correlated with the motor disability. Incapacity resulting from the dysautonomic fluctuations was also significantly correlated with levodopa treatment. Surprisingly, 28% of the patients stated that NMF involved a greater degree of disability than MF. Conclusion: Nonmotor fluctuations are frequent and debilitating in PD.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001061
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :000375
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000F08
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003A23
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001172
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001131
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001131
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000263
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000263
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000263
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003822
Links to Exploration step
Pascal:02-0469214Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Nonmotor fluctuations in Parkinson's disease: Frequent and disabling</title>
<author><name sortKey="Witjas, T" sort="Witjas, T" uniqKey="Witjas T" first="T." last="Witjas">T. Witjas</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaphan, E" sort="Kaphan, E" uniqKey="Kaphan E" first="E." last="Kaphan">E. Kaphan</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J. P." last="Azulay">J. P. Azulay</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O." last="Blin">O. Blin</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CPCET, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ceccaldi, M" sort="Ceccaldi, M" uniqKey="Ceccaldi M" first="M." last="Ceccaldi">M. Ceccaldi</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pouget, J" sort="Pouget, J" uniqKey="Pouget J" first="J." last="Pouget">J. Pouget</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poncet, M" sort="Poncet, M" uniqKey="Poncet M" first="M." last="Poncet">M. Poncet</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ali Cherif, A" sort="Ali Cherif, A" uniqKey="Ali Cherif A" first="A." last="Ali Cherif">A. Ali Cherif</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">02-0469214</idno>
<date when="2002">2002</date>
<idno type="stanalyst">PASCAL 02-0469214 INIST</idno>
<idno type="RBID">Pascal:02-0469214</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001061</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000375</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000F08</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000F08</idno>
<idno type="wicri:doubleKey">0028-3878:2002:Witjas T:nonmotor:fluctuations:in</idno>
<idno type="wicri:Area/Main/Merge">003A23</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:12177375</idno>
<idno type="wicri:Area/PubMed/Corpus">001172</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001172</idno>
<idno type="wicri:Area/PubMed/Curation">001131</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001131</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001131</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001131</idno>
<idno type="wicri:Area/Ncbi/Merge">000263</idno>
<idno type="wicri:Area/Ncbi/Curation">000263</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000263</idno>
<idno type="wicri:doubleKey">0028-3878:2002:Witjas T:nonmotor:fluctuations:in</idno>
<idno type="wicri:Area/Main/Merge">003822</idno>
<idno type="wicri:Area/Main/Curation">003489</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Nonmotor fluctuations in Parkinson's disease: Frequent and disabling</title>
<author><name sortKey="Witjas, T" sort="Witjas, T" uniqKey="Witjas T" first="T." last="Witjas">T. Witjas</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaphan, E" sort="Kaphan, E" uniqKey="Kaphan E" first="E." last="Kaphan">E. Kaphan</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J. P." last="Azulay">J. P. Azulay</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O." last="Blin">O. Blin</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CPCET, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ceccaldi, M" sort="Ceccaldi, M" uniqKey="Ceccaldi M" first="M." last="Ceccaldi">M. Ceccaldi</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pouget, J" sort="Pouget, J" uniqKey="Pouget J" first="J." last="Pouget">J. Pouget</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poncet, M" sort="Poncet, M" uniqKey="Poncet M" first="M." last="Poncet">M. Poncet</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ali Cherif, A" sort="Ali Cherif, A" uniqKey="Ali Cherif A" first="A." last="Ali Cherif">A. Ali Cherif</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Autonomic Nervous System Diseases (epidemiology)</term>
<term>Autonomic Nervous System Diseases (physiopathology)</term>
<term>Autonomic Nervous System Diseases (psychology)</term>
<term>Chi-Square Distribution</term>
<term>Cognition Disorders (epidemiology)</term>
<term>Cognition Disorders (physiopathology)</term>
<term>Cognition Disorders (psychology)</term>
<term>Female</term>
<term>Fluctuations</term>
<term>Frequency</term>
<term>Handicap</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson disease</term>
<term>Prospective Studies</term>
<term>Questionnaire</term>
<term>Sensation Disorders (epidemiology)</term>
<term>Sensation Disorders (physiopathology)</term>
<term>Sensation Disorders (psychology)</term>
<term>Statistics, Nonparametric</term>
<term>Surveys and Questionnaires</term>
<term>Symptomatology</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Autonomic Nervous System Diseases</term>
<term>Cognition Disorders</term>
<term>Parkinson Disease</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Autonomic Nervous System Diseases</term>
<term>Cognition Disorders</term>
<term>Parkinson Disease</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Autonomic Nervous System Diseases</term>
<term>Cognition Disorders</term>
<term>Parkinson Disease</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Chi-Square Distribution</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Statistics, Nonparametric</term>
<term>Surveys and Questionnaires</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Fluctuation</term>
<term>Handicap</term>
<term>Symptomatologie</term>
<term>Fréquence</term>
<term>Homme</term>
<term>Questionnaire</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: To assess the frequency and disability caused by nonmotor fluctuations (NMF) in PD. Methods: A structured questionnaire was administered to 50 patients with PD with motor fluctuations (MF), focused on 54 nonmotor symptoms classified in three subgroups: 26 dysautonomic, 21 cognitive and psychiatric, and seven pain/sensory NMF. The link between each NMF and the motor state was determined. Patients were asked to grade their disability from 0 (no disability) to 4 (maximum discomfort) and to specify which kind of fluctuation subgroup (motor or nonmotor) was the most incapacitating. A statistical analysis was performed to determine the frequency of each NMF and to determine whether the level of disability resulting from NMF could be correlated to the main characteristics of the population. Results: All patients had had at least one type of NMF, most of which were associated with the "off" state. Anxiety (66%), drenching sweats (64%), slowness of thinking (58%), fatigue (56%), and akathisia (54%) were the most frequent NMF. Some symptoms such as anxiety or dyspnea correlated with a greater level of disability. The total number of NMF was found to be correlated with the motor disability. Incapacity resulting from the dysautonomic fluctuations was also significantly correlated with levodopa treatment. Surprisingly, 28% of the patients stated that NMF involved a greater degree of disability than MF. Conclusion: Nonmotor fluctuations are frequent and debilitating in PD.</div>
</front>
</TEI>
<double idat="0028-3878:2002:Witjas T:nonmotor:fluctuations:in"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Nonmotor fluctuations in Parkinson's disease: Frequent and disabling</title>
<author><name sortKey="Witjas, T" sort="Witjas, T" uniqKey="Witjas T" first="T." last="Witjas">T. Witjas</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaphan, E" sort="Kaphan, E" uniqKey="Kaphan E" first="E." last="Kaphan">E. Kaphan</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J. P." last="Azulay">J. P. Azulay</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O." last="Blin">O. Blin</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CPCET, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ceccaldi, M" sort="Ceccaldi, M" uniqKey="Ceccaldi M" first="M." last="Ceccaldi">M. Ceccaldi</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pouget, J" sort="Pouget, J" uniqKey="Pouget J" first="J." last="Pouget">J. Pouget</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poncet, M" sort="Poncet, M" uniqKey="Poncet M" first="M." last="Poncet">M. Poncet</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ali Cherif, A" sort="Ali Cherif, A" uniqKey="Ali Cherif A" first="A." last="Ali Cherif">A. Ali Cherif</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">02-0469214</idno>
<date when="2002">2002</date>
<idno type="stanalyst">PASCAL 02-0469214 INIST</idno>
<idno type="RBID">Pascal:02-0469214</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001061</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000375</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000F08</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000F08</idno>
<idno type="wicri:doubleKey">0028-3878:2002:Witjas T:nonmotor:fluctuations:in</idno>
<idno type="wicri:Area/Main/Merge">003A23</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Nonmotor fluctuations in Parkinson's disease: Frequent and disabling</title>
<author><name sortKey="Witjas, T" sort="Witjas, T" uniqKey="Witjas T" first="T." last="Witjas">T. Witjas</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaphan, E" sort="Kaphan, E" uniqKey="Kaphan E" first="E." last="Kaphan">E. Kaphan</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J. P." last="Azulay">J. P. Azulay</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O." last="Blin">O. Blin</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CPCET, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ceccaldi, M" sort="Ceccaldi, M" uniqKey="Ceccaldi M" first="M." last="Ceccaldi">M. Ceccaldi</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pouget, J" sort="Pouget, J" uniqKey="Pouget J" first="J." last="Pouget">J. Pouget</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poncet, M" sort="Poncet, M" uniqKey="Poncet M" first="M." last="Poncet">M. Poncet</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ali Cherif, A" sort="Ali Cherif, A" uniqKey="Ali Cherif A" first="A." last="Ali Cherif">A. Ali Cherif</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, CHU Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Fluctuations</term>
<term>Frequency</term>
<term>Handicap</term>
<term>Human</term>
<term>Parkinson disease</term>
<term>Questionnaire</term>
<term>Symptomatology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Fluctuation</term>
<term>Handicap</term>
<term>Symptomatologie</term>
<term>Fréquence</term>
<term>Homme</term>
<term>Questionnaire</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: To assess the frequency and disability caused by nonmotor fluctuations (NMF) in PD. Methods: A structured questionnaire was administered to 50 patients with PD with motor fluctuations (MF), focused on 54 nonmotor symptoms classified in three subgroups: 26 dysautonomic, 21 cognitive and psychiatric, and seven pain/sensory NMF. The link between each NMF and the motor state was determined. Patients were asked to grade their disability from 0 (no disability) to 4 (maximum discomfort) and to specify which kind of fluctuation subgroup (motor or nonmotor) was the most incapacitating. A statistical analysis was performed to determine the frequency of each NMF and to determine whether the level of disability resulting from NMF could be correlated to the main characteristics of the population. Results: All patients had had at least one type of NMF, most of which were associated with the "off" state. Anxiety (66%), drenching sweats (64%), slowness of thinking (58%), fatigue (56%), and akathisia (54%) were the most frequent NMF. Some symptoms such as anxiety or dyspnea correlated with a greater level of disability. The total number of NMF was found to be correlated with the motor disability. Incapacity resulting from the dysautonomic fluctuations was also significantly correlated with levodopa treatment. Surprisingly, 28% of the patients stated that NMF involved a greater degree of disability than MF. Conclusion: Nonmotor fluctuations are frequent and debilitating in PD.</div>
</front>
</TEI>
</INIST>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nonmotor fluctuations in Parkinson's disease: frequent and disabling.</title>
<author><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, CHU Timone, 264 rue Saint Pierre, 13385 Marseille cedex 05, France. twitjas@yahoo.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, CHU Timone, 264 rue Saint Pierre, 13385 Marseille cedex 05</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaphan, E" sort="Kaphan, E" uniqKey="Kaphan E" first="E" last="Kaphan">E. Kaphan</name>
</author>
<author><name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J P" last="Azulay">J P Azulay</name>
</author>
<author><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O" last="Blin">O. Blin</name>
</author>
<author><name sortKey="Ceccaldi, M" sort="Ceccaldi, M" uniqKey="Ceccaldi M" first="M" last="Ceccaldi">M. Ceccaldi</name>
</author>
<author><name sortKey="Pouget, J" sort="Pouget, J" uniqKey="Pouget J" first="J" last="Pouget">J. Pouget</name>
</author>
<author><name sortKey="Poncet, M" sort="Poncet, M" uniqKey="Poncet M" first="M" last="Poncet">M. Poncet</name>
</author>
<author><name sortKey="Cherif, A Ali" sort="Cherif, A Ali" uniqKey="Cherif A" first="A Ali" last="Chérif">A Ali Chérif</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2002">2002</date>
<idno type="RBID">pubmed:12177375</idno>
<idno type="pmid">12177375</idno>
<idno type="wicri:Area/PubMed/Corpus">001172</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001172</idno>
<idno type="wicri:Area/PubMed/Curation">001131</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001131</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001131</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001131</idno>
<idno type="wicri:Area/Ncbi/Merge">000263</idno>
<idno type="wicri:Area/Ncbi/Curation">000263</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000263</idno>
<idno type="wicri:doubleKey">0028-3878:2002:Witjas T:nonmotor:fluctuations:in</idno>
<idno type="wicri:Area/Main/Merge">003822</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Nonmotor fluctuations in Parkinson's disease: frequent and disabling.</title>
<author><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, CHU Timone, 264 rue Saint Pierre, 13385 Marseille cedex 05, France. twitjas@yahoo.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, CHU Timone, 264 rue Saint Pierre, 13385 Marseille cedex 05</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaphan, E" sort="Kaphan, E" uniqKey="Kaphan E" first="E" last="Kaphan">E. Kaphan</name>
</author>
<author><name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J P" last="Azulay">J P Azulay</name>
</author>
<author><name sortKey="Blin, O" sort="Blin, O" uniqKey="Blin O" first="O" last="Blin">O. Blin</name>
</author>
<author><name sortKey="Ceccaldi, M" sort="Ceccaldi, M" uniqKey="Ceccaldi M" first="M" last="Ceccaldi">M. Ceccaldi</name>
</author>
<author><name sortKey="Pouget, J" sort="Pouget, J" uniqKey="Pouget J" first="J" last="Pouget">J. Pouget</name>
</author>
<author><name sortKey="Poncet, M" sort="Poncet, M" uniqKey="Poncet M" first="M" last="Poncet">M. Poncet</name>
</author>
<author><name sortKey="Cherif, A Ali" sort="Cherif, A Ali" uniqKey="Cherif A" first="A Ali" last="Chérif">A Ali Chérif</name>
</author>
</analytic>
<series><title level="j">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2002" type="published">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Autonomic Nervous System Diseases (epidemiology)</term>
<term>Autonomic Nervous System Diseases (physiopathology)</term>
<term>Autonomic Nervous System Diseases (psychology)</term>
<term>Chi-Square Distribution</term>
<term>Cognition Disorders (epidemiology)</term>
<term>Cognition Disorders (physiopathology)</term>
<term>Cognition Disorders (psychology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Prospective Studies</term>
<term>Sensation Disorders (epidemiology)</term>
<term>Sensation Disorders (physiopathology)</term>
<term>Sensation Disorders (psychology)</term>
<term>Statistics, Nonparametric</term>
<term>Surveys and Questionnaires</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Autonomic Nervous System Diseases</term>
<term>Cognition Disorders</term>
<term>Parkinson Disease</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Autonomic Nervous System Diseases</term>
<term>Cognition Disorders</term>
<term>Parkinson Disease</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Autonomic Nervous System Diseases</term>
<term>Cognition Disorders</term>
<term>Parkinson Disease</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Chi-Square Distribution</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Statistics, Nonparametric</term>
<term>Surveys and Questionnaires</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To assess the frequency and disability caused by nonmotor fluctuations (NMF) in PD.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003489 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 003489 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Curation |type= RBID |clé= Pascal:02-0469214 |texte= Nonmotor fluctuations in Parkinson's disease: Frequent and disabling }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |