Subthalamic deep brain stimulation increases pallidal firing rate and regularity
Identifieur interne : 001807 ( Main/Curation ); précédent : 001806; suivant : 001808Subthalamic deep brain stimulation increases pallidal firing rate and regularity
Auteurs : René Reese [Allemagne] ; Arthur Leblois [France] ; Frank Steigerwald [Allemagne] ; Monika Pötter-Nerger [Allemagne] ; Jan Herzog [Allemagne] ; H. Maximilian Mehdorn [Allemagne] ; Günther Deuschl [Allemagne] ; Wassilios G. Meissner [France] ; Jens Volkmann [Allemagne]Source :
- Experimental neurology : (Print) [ 0014-4886 ] ; 2011.
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- Pascal (Inist)
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Abstract
While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.
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<term>High frequency</term>
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<term>Mode décharge</term>
<term>Noyau sousthalamique</term>
<term>Haute fréquence</term>
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<term>Electrophysiologie</term>
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<front><div type="abstract" xml:lang="en">While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.</div>
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