Subthalamic deep brain stimulation increases pallidal firing rate and regularity
Identifieur interne : 000389 ( PascalFrancis/Corpus ); précédent : 000388; suivant : 000390Subthalamic deep brain stimulation increases pallidal firing rate and regularity
Auteurs : René Reese ; Arthur Leblois ; Frank Steigerwald ; Monika Pötter-Nerger ; Jan Herzog ; H. Maximilian Mehdorn ; Günther Deuschl ; Wassilios G. Meissner ; Jens VolkmannSource :
- Experimental neurology : (Print) [ 0014-4886 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.
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Format Inist (serveur)
NO : | PASCAL 11-0308790 INIST |
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ET : | Subthalamic deep brain stimulation increases pallidal firing rate and regularity |
AU : | REESE (René); LEBLOIS (Arthur); STEIGERWALD (Frank); PÖTTER-NERGER (Monika); HERZOG (Jan); MAXIMILIAN MEHDORN (H.); DEUSCHL (Günther); MEISSNER (Wassilios G.); VOLKMANN (Jens) |
AF : | Department of Neurology, University Hospitals Schleswig-Holstein/Kiel/Allemagne (1 aut., 3 aut., 4 aut., 5 aut., 7 aut., 9 aut.); Laboratoire de Neurophysique et Physiologie, CNRS UMR 8119, Université René Descartes/Paris/France (2 aut.); Department of Neurosurgery, University Hospitals Schleswig-Holstein/Kiel/Allemagne (6 aut.); Service de Neurologie, CHU Bordeaux/France (8 aut.); Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université Bordeaux 2/France (8 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Experimental neurology : (Print); ISSN 0014-4886; Coden EXNEAC; Pays-Bas; Da. 2011; Vol. 229; No. 2; Pp. 517-521; Bibl. 1/2 p. |
LA : | Anglais |
EA : | While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD. |
CC : | 002B17; 002B26I |
FD : | Maladie de Parkinson; Pathologie du système nerveux; Mode décharge; Noyau sousthalamique; Haute fréquence; Noyau gris central; Electrophysiologie; Stimulation cérébrale profonde |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central |
ED : | Parkinson disease; Nervous system diseases; Discharge pattern; Subthalamic nucleus; High frequency; Basal ganglion; Electrophysiology; Deep brain stimulation |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system |
SD : | Parkinson enfermedad; Sistema nervioso patología; Forma descarga; Núcleo subtalámico; Alta frecuencia; Núcleo basal; Electrofisiología |
LO : | INIST-9181.354000190415410370 |
ID : | 11-0308790 |
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Pascal:11-0308790Le document en format XML
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<front><div type="abstract" xml:lang="en">While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.</div>
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<fC03 i1="06" i2="X" l="SPA"><s0>Núcleo basal</s0>
<s5>12</s5>
</fC03>
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<s5>13</s5>
</fC03>
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<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Electrofisiología</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Stimulation cérébrale profonde</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Deep brain stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
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<s5>37</s5>
</fC07>
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<s5>37</s5>
</fC07>
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<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>43</s5>
</fC07>
<fN21><s1>213</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
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<server><NO>PASCAL 11-0308790 INIST</NO>
<ET>Subthalamic deep brain stimulation increases pallidal firing rate and regularity</ET>
<AU>REESE (René); LEBLOIS (Arthur); STEIGERWALD (Frank); PÖTTER-NERGER (Monika); HERZOG (Jan); MAXIMILIAN MEHDORN (H.); DEUSCHL (Günther); MEISSNER (Wassilios G.); VOLKMANN (Jens)</AU>
<AF>Department of Neurology, University Hospitals Schleswig-Holstein/Kiel/Allemagne (1 aut., 3 aut., 4 aut., 5 aut., 7 aut., 9 aut.); Laboratoire de Neurophysique et Physiologie, CNRS UMR 8119, Université René Descartes/Paris/France (2 aut.); Department of Neurosurgery, University Hospitals Schleswig-Holstein/Kiel/Allemagne (6 aut.); Service de Neurologie, CHU Bordeaux/France (8 aut.); Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université Bordeaux 2/France (8 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Experimental neurology : (Print); ISSN 0014-4886; Coden EXNEAC; Pays-Bas; Da. 2011; Vol. 229; No. 2; Pp. 517-521; Bibl. 1/2 p.</SO>
<LA>Anglais</LA>
<EA>While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.</EA>
<CC>002B17; 002B26I</CC>
<FD>Maladie de Parkinson; Pathologie du système nerveux; Mode décharge; Noyau sousthalamique; Haute fréquence; Noyau gris central; Electrophysiologie; Stimulation cérébrale profonde</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Discharge pattern; Subthalamic nucleus; High frequency; Basal ganglion; Electrophysiology; Deep brain stimulation</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Forma descarga; Núcleo subtalámico; Alta frecuencia; Núcleo basal; Electrofisiología</SD>
<LO>INIST-9181.354000190415410370</LO>
<ID>11-0308790</ID>
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