Subthalamic deep brain stimulation increases pallidal firing rate and regularity
Identifieur interne : 001893 ( Main/Merge ); précédent : 001892; suivant : 001894Subthalamic deep brain stimulation increases pallidal firing rate and regularity
Auteurs : René Reese [Allemagne] ; Arthur Leblois [France] ; Frank Steigerwald [Allemagne] ; Monika Pötter-Nerger [Allemagne] ; Jan Herzog [Allemagne] ; H. Maximilian Mehdorn [Allemagne] ; Günther Deuschl [Allemagne] ; Wassilios G. Meissner [France] ; Jens Volkmann [Allemagne]Source :
- Experimental neurology : (Print) [ 0014-4886 ] ; 2011.
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- Pascal (Inist)
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Abstract
While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.
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Maximilian Mehdorn</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurosurgery, University Hospitals Schleswig-Holstein</s1><s2>Kiel</s2><s3>DEU</s3><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospitals Schleswig-Holstein</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Service de Neurologie, CHU Bordeaux</s1><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>CHU Bordeaux</wicri:noRegion><wicri:noRegion>Service de Neurologie, CHU Bordeaux</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université Bordeaux 2</s1><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Université Bordeaux 2</wicri:noRegion><wicri:noRegion>Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université Bordeaux 2</wicri:noRegion></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospitals Schleswig-Holstein</s1><s2>Kiel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Experimental neurology : (Print)</title><title level="j" type="abbreviated">Exp. neurol. : (Print)</title><idno type="ISSN">0014-4886</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Experimental neurology : (Print)</title><title level="j" type="abbreviated">Exp. neurol. : (Print)</title><idno type="ISSN">0014-4886</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglion</term><term>Deep brain stimulation</term><term>Discharge pattern</term><term>Electrophysiology</term><term>High frequency</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Mode décharge</term><term>Noyau sousthalamique</term><term>Haute fréquence</term><term>Noyau gris central</term><term>Electrophysiologie</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li></country><region><li>Schleswig-Holstein</li><li>Île-de-France</li></region><settlement><li>Kiel</li><li>Paris</li></settlement></list><tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Reese, Rene" sort="Reese, Rene" uniqKey="Reese R" first="René" last="Reese">René Reese</name></region><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name><name sortKey="Maximilian Mehdorn, H" sort="Maximilian Mehdorn, H" uniqKey="Maximilian Mehdorn H" first="H." last="Maximilian Mehdorn">H. Maximilian Mehdorn</name><name sortKey="Potter Nerger, Monika" sort="Potter Nerger, Monika" uniqKey="Potter Nerger M" first="Monika" last="Pötter-Nerger">Monika Pötter-Nerger</name><name sortKey="Steigerwald, Frank" sort="Steigerwald, Frank" uniqKey="Steigerwald F" first="Frank" last="Steigerwald">Frank Steigerwald</name><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></country><country name="France"><region name="Île-de-France"><name sortKey="Leblois, Arthur" sort="Leblois, Arthur" uniqKey="Leblois A" first="Arthur" last="Leblois">Arthur Leblois</name></region><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. 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