ParkinsonFranceV1, PascalFrancis, Curation, bibRecord, 000F50

Subthalamic deep brain stimulation increases pallidal firing rate and regularity

Identifieur interne : 000F50 ( PascalFrancis/Curation ); précédent : 000F49; suivant : 000F51

Subthalamic deep brain stimulation increases pallidal firing rate and regularity

Auteurs : René Reese [Allemagne] ; Arthur Leblois [France] ; Frank Steigerwald [Allemagne] ; Monika Pötter-Nerger [Allemagne] ; Jan Herzog [Allemagne] ; H. Maximilian Mehdorn [Allemagne] ; Günther Deuschl [Allemagne] ; Wassilios G. Meissner [France] ; Jens Volkmann [Allemagne]

Source :

Experimental neurology : (Print) [ 0014-4886 ] ; 2011.

RBID : Pascal:11-0308790

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Mode décharge, Noyau sousthalamique, Haute fréquence, Noyau gris central, Electrophysiologie, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Basal ganglion, Deep brain stimulation, Discharge pattern, Electrophysiology, High frequency, Nervous system diseases, Parkinson disease, Subthalamic nucleus.

Abstract

While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.

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A03		`1`		`@0 Exp. neurol. : (Print)`
A05				`@2 229`
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A08	`01`	`1`	`ENG`	`@1 Subthalamic deep brain stimulation increases pallidal firing rate and regularity`
A11	`01`	`1`		`@1 REESE (René)`
A11	`02`	`1`		`@1 LEBLOIS (Arthur)`
A11	`03`	`1`		`@1 STEIGERWALD (Frank)`
A11	`04`	`1`		`@1 PÖTTER-NERGER (Monika)`
A11	`05`	`1`		`@1 HERZOG (Jan)`
A11	`06`	`1`		`@1 MAXIMILIAN MEHDORN (H.)`
A11	`07`	`1`		`@1 DEUSCHL (Günther)`
A11	`08`	`1`		`@1 MEISSNER (Wassilios G.)`
A11	`09`	`1`		`@1 VOLKMANN (Jens)`
A14	`01`			`@1 Department of Neurology, University Hospitals Schleswig-Holstein @2 Kiel @3 DEU @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 7 aut. @Z 9 aut.`
A14	`02`			`@1 Laboratoire de Neurophysique et Physiologie, CNRS UMR 8119, Université René Descartes @2 Paris @3 FRA @Z 2 aut.`
A14	`03`			`@1 Department of Neurosurgery, University Hospitals Schleswig-Holstein @2 Kiel @3 DEU @Z 6 aut.`
A14	`04`			`@1 Service de Neurologie, CHU Bordeaux @3 FRA @Z 8 aut.`
A14	`05`			`@1 Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université Bordeaux 2 @3 FRA @Z 8 aut.`
A20				`@1 517-521`
A21				`@1 2011`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 9181 @5 354000190415410370`
A44				`@0 0000 @1 © 2011 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B26I`
C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Mode décharge @5 09`
C03	`03`	`X`	`ENG`	`@0 Discharge pattern @5 09`
C03	`03`	`X`	`SPA`	`@0 Forma descarga @5 09`
C03	`04`	`X`	`FRE`	`@0 Noyau sousthalamique @5 10`
C03	`04`	`X`	`ENG`	`@0 Subthalamic nucleus @5 10`
C03	`04`	`X`	`SPA`	`@0 Núcleo subtalámico @5 10`
C03	`05`	`X`	`FRE`	`@0 Haute fréquence @5 11`
C03	`05`	`X`	`ENG`	`@0 High frequency @5 11`
C03	`05`	`X`	`SPA`	`@0 Alta frecuencia @5 11`
C03	`06`	`X`	`FRE`	`@0 Noyau gris central @5 12`
C03	`06`	`X`	`ENG`	`@0 Basal ganglion @5 12`
C03	`06`	`X`	`SPA`	`@0 Núcleo basal @5 12`
C03	`07`	`X`	`FRE`	`@0 Electrophysiologie @5 13`
C03	`07`	`X`	`ENG`	`@0 Electrophysiology @5 13`
C03	`07`	`X`	`SPA`	`@0 Electrofisiología @5 13`
C03	`08`	`X`	`FRE`	`@0 Stimulation cérébrale profonde @4 CD @5 96`
C03	`08`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
C07	`05`	`X`	`FRE`	`@0 Encéphale @5 42`
C07	`05`	`X`	`ENG`	`@0 Encephalon @5 42`
C07	`05`	`X`	`SPA`	`@0 Encéfalo @5 42`
C07	`06`	`X`	`FRE`	`@0 Système nerveux central @5 43`
C07	`06`	`X`	`ENG`	`@0 Central nervous system @5 43`
C07	`06`	`X`	`SPA`	`@0 Sistema nervioso central @5 43`
N21				`@1 213`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglion</term>
<term>Deep brain stimulation</term>
<term>Discharge pattern</term>
<term>Electrophysiology</term>
<term>High frequency</term>
<term>Nervous system diseases</term>
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</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
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<front><div type="abstract" xml:lang="en">While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.</div>
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</fA11>
<fA11 i1="07" i2="1"><s1>DEUSCHL (Günther)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>MEISSNER (Wassilios G.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>VOLKMANN (Jens)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Neurology, University Hospitals Schleswig-Holstein</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Laboratoire de Neurophysique et Physiologie, CNRS UMR 8119, Université René Descartes</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Neurosurgery, University Hospitals Schleswig-Holstein</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Service de Neurologie, CHU Bordeaux</s1>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université Bordeaux 2</s1>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>517-521</s1>
</fA20>
<fA21><s1>2011</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>9181</s2>
<s5>354000190415410370</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2011 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>1/2 p.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>11-0308790</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Experimental neurology : (Print)</s0>
</fA64>
<fA66 i1="01"><s0>NLD</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B26I</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Mode décharge</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Discharge pattern</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Forma descarga</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Noyau sousthalamique</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Subthalamic nucleus</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Núcleo subtalámico</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Haute fréquence</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>High frequency</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Alta frecuencia</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Noyau gris central</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Basal ganglion</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Núcleo basal</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Electrophysiologie</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Electrophysiology</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Electrofisiología</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Stimulation cérébrale profonde</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Deep brain stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>43</s5>
</fC07>
<fN21><s1>213</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Subthalamic deep brain stimulation increases pallidal firing rate and regularity

Subthalamic deep brain stimulation increases pallidal firing rate and regularity

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