Novel Avian-Origin Influenza A (H7N9) Virus Attaches to Epithelium in Both Upper and Lower Respiratory Tract of Humans
Identifieur interne : 001313 ( Main/Merge ); précédent : 001312; suivant : 001314Novel Avian-Origin Influenza A (H7N9) Virus Attaches to Epithelium in Both Upper and Lower Respiratory Tract of Humans
Auteurs : Debby Van Riel ; Lonneke M. E. Leijten ; Miranda De Graaf ; Jurre Y. Siegers ; Kirsty R. Short ; Monique I. J. Spronken ; Eefje J. A. Schrauwen ; Ron A. M. Fouchier ; Albert D. M. E. Osterhaus ; Thijs KuikenSource :
- The American Journal of Pathology [ 0002-9440 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Appareil respiratoire (anatomopathologie), Appareil respiratoire (virologie), Attachement viral, Dindons, Glycoprotéine hémagglutinine du virus influenza (métabolisme), Grippe chez les oiseaux (virologie), Grippe humaine (virologie), Humains, Jeune adulte, Récepteurs viraux (métabolisme), Sous-type H7N9 du virus de la grippe A (physiologie), Sujet âgé, Tests d'hémagglutination, Virus recombinants, Épithélium (anatomopathologie), Épithélium (virologie), Érythrocytes (métabolisme).
- MESH :
- anatomopathologie : Appareil respiratoire, Épithélium.
- métabolisme : Glycoprotéine hémagglutinine du virus influenza, Récepteurs viraux, Érythrocytes.
- physiologie : Sous-type H7N9 du virus de la grippe A.
- virologie : Appareil respiratoire, Grippe chez les oiseaux, Grippe humaine, Épithélium.
- Adulte, Adulte d'âge moyen, Animaux, Attachement viral, Dindons, Humains, Jeune adulte, Sujet âgé, Tests d'hémagglutination, Virus recombinants.
English descriptors
- KwdEn :
- Adult, Aged, Animals, Epithelium (pathology), Epithelium (virology), Erythrocytes (metabolism), Hemagglutination Tests, Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Humans, Influenza A Virus, H7N9 Subtype (physiology), Influenza in Birds (virology), Influenza, Human (virology), Middle Aged, Reassortant Viruses, Receptors, Virus (metabolism), Respiratory System (pathology), Respiratory System (virology), Turkeys, Virus Attachment, Young Adult.
- MESH :
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus, Receptors, Virus.
- metabolism : Erythrocytes.
- pathology : Epithelium, Respiratory System.
- physiology : Influenza A Virus, H7N9 Subtype.
- virology : Epithelium, Influenza in Birds, Influenza, Human, Respiratory System.
- Adult, Aged, Animals, Hemagglutination Tests, Humans, Middle Aged, Reassortant Viruses, Turkeys, Virus Attachment, Young Adult.
Abstract
Influenza A viruses from animal reservoirs have the capacity to adapt to humans and cause influenza pandemics. The occurrence of an influenza pandemic requires efficient virus transmission among humans, which is associated with virus attachment to the upper respiratory tract. Pandemic severity depends on virus ability to cause pneumonia, which is associated with virus attachment to the lower respiratory tract. Recently, a novel avian-origin H7N9 influenza A virus with unknown pandemic potential emerged in humans. We determined the pattern of attachment of two genetically engineered viruses containing the hemagglutinin of either influenza virus A/Shanghai/1/13 or A/Anhui/1/13 to formalin-fixed human respiratory tract tissues using histochemical analysis. Our results show that the emerging H7N9 virus attached moderately or abundantly to both upper and lower respiratory tract, a pattern not seen before for avian influenza A viruses. With the caveat that virus attachment is only the first step in the virus replication cycle, these results suggest that the emerging H7N9 virus has the potential both to transmit efficiently among humans and to cause severe pneumonia.
Url:
DOI: 10.1016/j.ajpath.2013.06.011
PubMed: 24029490
PubMed Central: 3791677
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PMC:3791677Le document en format XML
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The occurrence of an influenza pandemic requires efficient virus transmission among humans, which is associated with virus attachment to the upper respiratory tract. Pandemic severity depends on virus ability to cause pneumonia, which is associated with virus attachment to the lower respiratory tract. Recently, a novel avian-origin H7N9 influenza A virus with unknown pandemic potential emerged in humans. We determined the pattern of attachment of two genetically engineered viruses containing the hemagglutinin of either influenza virus A/Shanghai/1/13 or A/Anhui/1/13 to formalin-fixed human respiratory tract tissues using histochemical analysis. Our results show that the emerging H7N9 virus attached moderately or abundantly to both upper and lower respiratory tract, a pattern not seen before for avian influenza A viruses. With the caveat that virus attachment is only the first step in the virus replication cycle, these results suggest that the emerging H7N9 virus has the potential both to transmit efficiently among humans and to cause severe pneumonia.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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