Obesity as a risk factor for severe influenza-like illness
Identifieur interne : 001312 ( Main/Merge ); précédent : 001311; suivant : 001313Obesity as a risk factor for severe influenza-like illness
Auteurs : Noelle M. Cocoros [États-Unis] ; Timothy L. Lash [États-Unis] ; Alfred Demaria [États-Unis] ; Michael Klompas [États-Unis]Source :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Grippe humaine.
- épidémiologie : Grippe humaine.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Hospitalisation, Humains, Indice de masse corporelle, Jeune adulte, Mâle, Obésité, Sujet âgé, Sujet âgé de 80 ans ou plus, Études cas-témoins.
English descriptors
- KwdEn :
- MESH :
- complications : Obesity.
- epidemiology : Influenza, Human.
- pathology : Influenza, Human.
- statistics & numerical data : Hospitalization.
- Adult, Aged, Aged, 80 and over, Body Mass Index, Case-Control Studies, Female, Humans, Male, Middle Aged, Risk Factors, Young Adult.
Abstract
Obesity was recognized as in independent risk factor for influenza during the 2009 H1N1 influenza pandemic.
We evaluated the association between body mass index (BMI) and influenza-like illness (ILI) during two non-pandemic influenza seasons (2003–2004 and 2004–2005) and during the spring and fall waves of the 2009 H1N1 pandemic.
Adults with severe (inpatient) and mild (outpatient) ILI were compared to those without ILI using a case-cohort design. The study was nested among those insured by a single health insurance company, receiving care from a large multispecialty practice. Data were collected from insurance claims and the electronic health record. The primary exposure was obesity (BMI ≥ 30·0 kg/m2).
Across three seasons, the crude and adjusted ORs for obesity and severe ILI were 1·65 (95% CI 1·31, 2·08) and 1·23 (95% CI 0·97, 1·57), respectively. An association was observed for those aged 20–59 years (adjusted OR 1·92, 95% CI 1·26, 2·90), but not for those 60 and older (adjusted OR 1·08, 95% CI 0·80, 1·46). The adjusted ORs for obesity and severe ILI in 2003–2004, 2004–2005, and during H1N1 were 1·14 (95% CI 0·80, 1·64), 1·24 (95% CI 0·86, 1·79), and 1·76 (95% CI 0·91, 3·42), respectively. Among those with a Charlson Comorbidity Index score of zero, the adjusted ORs for 2003–2004, 2004–2005, and H1N1 were 1·60 (95% CI 0·93, 2·76), 1·43 (95% CI 0·80, 2·56), and 1·90 (95% CI 0·68, 5·27), respectively.
Our results suggest a small to moderate association between obesity and hospitalized ILI among adults.
Url:
DOI: 10.1111/irv.12156
PubMed: 23957732
PubMed Central: 4177795
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Cocoros</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Bureau of Infectious Disease, Massachusetts Department of Public Health</institution><addr-line>Jamaica Plain, MA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jamaica Plain, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lash, Timothy L" sort="Lash, Timothy L" uniqKey="Lash T" first="Timothy L" last="Lash">Timothy L. Lash</name><affiliation wicri:level="2"><nlm:aff id="au2"><institution>Department of Epidemiology, Rollins School of Public Health, Emory University</institution><addr-line>Atlanta, GA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Demaria, Alfred" sort="Demaria, Alfred" uniqKey="Demaria A" first="Alfred" last="Demaria">Alfred Demaria</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Bureau of Infectious Disease, Massachusetts Department of Public Health</institution><addr-line>Jamaica Plain, MA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jamaica Plain, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Klompas, Michael" sort="Klompas, Michael" uniqKey="Klompas M" first="Michael" last="Klompas">Michael Klompas</name><affiliation wicri:level="2"><nlm:aff id="au3"><institution>Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute</institution><addr-line>Boston, MA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><idno type="eISSN">1750-2659</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Body Mass Index</term><term>Case-Control Studies</term><term>Female</term><term>Hospitalization (statistics & numerical data)</term><term>Humans</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (pathology)</term><term>Male</term><term>Middle Aged</term><term>Obesity (complications)</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Grippe humaine (anatomopathologie)</term><term>Grippe humaine (épidémiologie)</term><term>Hospitalisation ()</term><term>Humains</term><term>Indice de masse corporelle</term><term>Jeune adulte</term><term>Mâle</term><term>Obésité ()</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Body Mass Index</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Indice de masse corporelle</term><term>Jeune adulte</term><term>Mâle</term><term>Obésité</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Obesity was recognized as in independent risk factor for influenza during the 2009 H1N1 influenza pandemic.</p></sec><sec><title>Objectives</title><p>We evaluated the association between body mass index (BMI) and influenza-like illness (ILI) during two non-pandemic influenza seasons (2003–2004 and 2004–2005) and during the spring and fall waves of the 2009 H1N1 pandemic.</p></sec><sec><title>Methods</title><p>Adults with severe (inpatient) and mild (outpatient) ILI were compared to those without ILI using a case-cohort design. The study was nested among those insured by a single health insurance company, receiving care from a large multispecialty practice. Data were collected from insurance claims and the electronic health record. The primary exposure was obesity (BMI ≥ 30·0 kg/m<sup>2</sup>).</p></sec><sec><title>Results</title><p>Across three seasons, the crude and adjusted ORs for obesity and severe ILI were 1·65 (95% CI 1·31, 2·08) and 1·23 (95% CI 0·97, 1·57), respectively. An association was observed for those aged 20–59 years (adjusted OR 1·92, 95% CI 1·26, 2·90), but not for those 60 and older (adjusted OR 1·08, 95% CI 0·80, 1·46). The adjusted ORs for obesity and severe ILI in 2003–2004, 2004–2005, and during H1N1 were 1·14 (95% CI 0·80, 1·64), 1·24 (95% CI 0·86, 1·79), and 1·76 (95% CI 0·91, 3·42), respectively. Among those with a Charlson Comorbidity Index score of zero, the adjusted ORs for 2003–2004, 2004–2005, and H1N1 were 1·60 (95% CI 0·93, 2·76), 1·43 (95% CI 0·80, 2·56), and 1·90 (95% CI 0·68, 5·27), respectively.</p></sec><sec><title>Conclusions</title><p>Our results suggest a small to moderate association between obesity and hospitalized ILI among adults.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author><author><name sortKey="Zarychanski, R" uniqKey="Zarychanski R">R Zarychanski</name></author><author><name sortKey="Pinto, R" uniqKey="Pinto R">R Pinto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Louie, Jk" uniqKey="Louie J">JK Louie</name></author><author><name sortKey="Acosta, M" uniqKey="Acosta M">M Acosta</name></author><author><name sortKey="Winter, K" uniqKey="Winter K">K Winter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Napolitano, Lm" uniqKey="Napolitano L">LM Napolitano</name></author><author><name sortKey="Park, Pk" uniqKey="Park P">PK Park</name></author><author><name sortKey="Sihler, Kc" uniqKey="Sihler K">KC Sihler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slopen, Me" uniqKey="Slopen M">ME Slopen</name></author><author><name sortKey="Mosquera, Mc" uniqKey="Mosquera M">MC Mosquera</name></author><author><name sortKey="Balter, S" uniqKey="Balter S">S Balter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ugarte, S" uniqKey="Ugarte S">S Ugarte</name></author><author><name sortKey="Arancibia, F" uniqKey="Arancibia F">F Arancibia</name></author><author><name sortKey="Soto, R" uniqKey="Soto R">R Soto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaillant, L" uniqKey="Vaillant L">L Vaillant</name></author><author><name sortKey="La Ruche, G" uniqKey="La Ruche G">G La Ruche</name></author><author><name sortKey="Tarantola, A" uniqKey="Tarantola A">A Tarantola</name></author><author><name sortKey="Barboza, P" uniqKey="Barboza P">P Barboza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuhrman, C" uniqKey="Fuhrman C">C Fuhrman</name></author><author><name sortKey="Bonmarin, I" uniqKey="Bonmarin I">I Bonmarin</name></author><author><name sortKey="Bitar, D" uniqKey="Bitar D">D Bitar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Louie, Jk" uniqKey="Louie J">JK Louie</name></author><author><name sortKey="Acosta, M" uniqKey="Acosta M">M Acosta</name></author><author><name sortKey="Samuel, Mc" uniqKey="Samuel M">MC Samuel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morgan, Ow" uniqKey="Morgan O">OW Morgan</name></author><author><name sortKey="Bramley, A" uniqKey="Bramley A">A Bramley</name></author><author><name sortKey="Fowlkes, A" uniqKey="Fowlkes A">A Fowlkes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, La" uniqKey="Coleman L">LA Coleman</name></author><author><name sortKey="Waring, Sc" uniqKey="Waring S">SC Waring</name></author><author><name sortKey="Irving, Sa" uniqKey="Irving S">SA Irving</name></author><author><name sortKey="Vandermause, M" uniqKey="Vandermause M">M Vandermause</name></author><author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name></author><author><name sortKey="Belongia, Ea" uniqKey="Belongia E">EA Belongia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwong, Jc" uniqKey="Kwong J">JC Kwong</name></author><author><name sortKey="Campitelli, Ma" uniqKey="Campitelli M">MA Campitelli</name></author><author><name sortKey="Rosella, Lc" uniqKey="Rosella L">LC Rosella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rothman, Kj" uniqKey="Rothman K">KJ Rothman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Yih, Wk" uniqKey="Yih W">WK Yih</name></author><author><name sortKey="Caldwell, B" uniqKey="Caldwell B">B Caldwell</name></author><author><name sortKey="Harmon, R" uniqKey="Harmon R">R Harmon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yih, Wk" uniqKey="Yih W">WK Yih</name></author><author><name sortKey="Deshpande, S" uniqKey="Deshpande S">S Deshpande</name></author><author><name sortKey="Fuller, C" uniqKey="Fuller C">C Fuller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greene, Sk" uniqKey="Greene S">SK Greene</name></author><author><name sortKey="Kulldorff, M" uniqKey="Kulldorff M">M Kulldorff</name></author><author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charlson, Me" uniqKey="Charlson M">ME Charlson</name></author><author><name sortKey="Pompei, P" uniqKey="Pompei P">P Pompei</name></author><author><name sortKey="Ales, Kl" uniqKey="Ales K">KL Ales</name></author><author><name sortKey="Mackenzie, Cr" uniqKey="Mackenzie C">CR MacKenzie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey=" Stbye, T" uniqKey=" Stbye T">T Østbye</name></author><author><name sortKey="Taylor, Dh" uniqKey="Taylor D">DH Taylor</name></author><author><name sortKey="Yancy, Ws" uniqKey="Yancy W">WS Yancy</name></author><author><name sortKey="Krause, Km" uniqKey="Krause K">KM Krause</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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