Novel Avian-Origin Influenza A (H7N9) Virus Attaches to Epithelium in Both Upper and Lower Respiratory Tract of Humans
Identifieur interne : 000563 ( Pmc/Checkpoint ); précédent : 000562; suivant : 000564Novel Avian-Origin Influenza A (H7N9) Virus Attaches to Epithelium in Both Upper and Lower Respiratory Tract of Humans
Auteurs : Debby Van Riel ; Lonneke M. E. Leijten ; Miranda De Graaf ; Jurre Y. Siegers ; Kirsty R. Short ; Monique I. J. Spronken ; Eefje J. A. Schrauwen ; Ron A. M. Fouchier ; Albert D. M. E. Osterhaus ; Thijs KuikenSource :
- The American Journal of Pathology [ 0002-9440 ] ; 2013.
Abstract
Influenza A viruses from animal reservoirs have the capacity to adapt to humans and cause influenza pandemics. The occurrence of an influenza pandemic requires efficient virus transmission among humans, which is associated with virus attachment to the upper respiratory tract. Pandemic severity depends on virus ability to cause pneumonia, which is associated with virus attachment to the lower respiratory tract. Recently, a novel avian-origin H7N9 influenza A virus with unknown pandemic potential emerged in humans. We determined the pattern of attachment of two genetically engineered viruses containing the hemagglutinin of either influenza virus A/Shanghai/1/13 or A/Anhui/1/13 to formalin-fixed human respiratory tract tissues using histochemical analysis. Our results show that the emerging H7N9 virus attached moderately or abundantly to both upper and lower respiratory tract, a pattern not seen before for avian influenza A viruses. With the caveat that virus attachment is only the first step in the virus replication cycle, these results suggest that the emerging H7N9 virus has the potential both to transmit efficiently among humans and to cause severe pneumonia.
Url:
DOI: 10.1016/j.ajpath.2013.06.011
PubMed: 24029490
PubMed Central: 3791677
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E." last="Leijten">Lonneke M. E. Leijten</name></author><author><name sortKey="De Graaf, Miranda" sort="De Graaf, Miranda" uniqKey="De Graaf M" first="Miranda" last="De Graaf">Miranda De Graaf</name></author><author><name sortKey="Siegers, Jurre Y" sort="Siegers, Jurre Y" uniqKey="Siegers J" first="Jurre Y." last="Siegers">Jurre Y. Siegers</name></author><author><name sortKey="Short, Kirsty R" sort="Short, Kirsty R" uniqKey="Short K" first="Kirsty R." last="Short">Kirsty R. Short</name></author><author><name sortKey="Spronken, Monique I J" sort="Spronken, Monique I J" uniqKey="Spronken M" first="Monique I. J." last="Spronken">Monique I. J. Spronken</name></author><author><name sortKey="Schrauwen, Eefje J A" sort="Schrauwen, Eefje J A" uniqKey="Schrauwen E" first="Eefje J. A." last="Schrauwen">Eefje J. A. Schrauwen</name></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name></author><author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name></author></analytic><series><title level="j">The American Journal of Pathology</title><idno type="ISSN">0002-9440</idno><idno type="eISSN">1525-2191</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza A viruses from animal reservoirs have the capacity to adapt to humans and cause influenza pandemics. The occurrence of an influenza pandemic requires efficient virus transmission among humans, which is associated with virus attachment to the upper respiratory tract. Pandemic severity depends on virus ability to cause pneumonia, which is associated with virus attachment to the lower respiratory tract. Recently, a novel avian-origin H7N9 influenza A virus with unknown pandemic potential emerged in humans. We determined the pattern of attachment of two genetically engineered viruses containing the hemagglutinin of either influenza virus A/Shanghai/1/13 or A/Anhui/1/13 to formalin-fixed human respiratory tract tissues using histochemical analysis. Our results show that the emerging H7N9 virus attached moderately or abundantly to both upper and lower respiratory tract, a pattern not seen before for avian influenza A viruses. With the caveat that virus attachment is only the first step in the virus replication cycle, these results suggest that the emerging H7N9 virus has the potential both to transmit efficiently among humans and to cause severe pneumonia.</p></div></front></TEI><pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Pathol</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Pathol</journal-id><journal-title-group><journal-title>The American Journal of Pathology</journal-title></journal-title-group><issn pub-type="ppub">0002-9440</issn><issn pub-type="epub">1525-2191</issn><publisher><publisher-name>American Society for Investigative Pathology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24029490</article-id><article-id pub-id-type="pmc">3791677</article-id><article-id pub-id-type="publisher-id">S0002-9440(13)00457-4</article-id><article-id pub-id-type="doi">10.1016/j.ajpath.2013.06.011</article-id><article-categories><subj-group subj-group-type="heading"><subject>Short Communication</subject></subj-group></article-categories><title-group><article-title>Novel Avian-Origin Influenza A (H7N9) Virus Attaches to Epithelium in Both Upper and Lower Respiratory Tract of Humans</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>van Riel</surname><given-names>Debby</given-names></name></contrib><contrib contrib-type="author"><name><surname>Leijten</surname><given-names>Lonneke M.E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>de Graaf</surname><given-names>Miranda</given-names></name></contrib><contrib contrib-type="author"><name><surname>Siegers</surname><given-names>Jurre Y.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Short</surname><given-names>Kirsty R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Spronken</surname><given-names>Monique I.J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Schrauwen</surname><given-names>Eefje J.A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Fouchier</surname><given-names>Ron A.M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Osterhaus</surname><given-names>Albert D.M.E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kuiken</surname><given-names>Thijs</given-names></name><email>t.kuiken@erasmusmc.nl</email><xref rid="cor1" ref-type="corresp">∗</xref></contrib></contrib-group><aff id="aff1">Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands</aff><author-notes><corresp id="cor1"><label>∗</label>Address correspondence to Thijs Kuiken, D.V.M., Ph.D., Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands. <email>t.kuiken@erasmusmc.nl</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>1</day><month>10</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>10</month><year>2013</year></pub-date><volume>183</volume><issue>4</issue><fpage>1137</fpage><lpage>1143</lpage><history><date date-type="accepted"><day>28</day><month>6</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>American Society for Investigative Pathology</copyright-holder><license><license-p>This document may be redistributed and reused, subject to <ext-link ext-link-type="uri" xlink:href="http://www.elsevier.com/wps/find/authorsview.authors/supplementalterms1.0">certain conditions</ext-link>.</license-p></license></permissions><abstract><p>Influenza A viruses from animal reservoirs have the capacity to adapt to humans and cause influenza pandemics. The occurrence of an influenza pandemic requires efficient virus transmission among humans, which is associated with virus attachment to the upper respiratory tract. Pandemic severity depends on virus ability to cause pneumonia, which is associated with virus attachment to the lower respiratory tract. Recently, a novel avian-origin H7N9 influenza A virus with unknown pandemic potential emerged in humans. We determined the pattern of attachment of two genetically engineered viruses containing the hemagglutinin of either influenza virus A/Shanghai/1/13 or A/Anhui/1/13 to formalin-fixed human respiratory tract tissues using histochemical analysis. Our results show that the emerging H7N9 virus attached moderately or abundantly to both upper and lower respiratory tract, a pattern not seen before for avian influenza A viruses. With the caveat that virus attachment is only the first step in the virus replication cycle, these results suggest that the emerging H7N9 virus has the potential both to transmit efficiently among humans and to cause severe pneumonia.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="De Graaf, Miranda" sort="De Graaf, Miranda" uniqKey="De Graaf M" first="Miranda" last="De Graaf">Miranda De Graaf</name><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><name sortKey="Leijten, Lonneke M E" sort="Leijten, Lonneke M E" uniqKey="Leijten L" first="Lonneke M. E." last="Leijten">Lonneke M. E. Leijten</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><name sortKey="Schrauwen, Eefje J A" sort="Schrauwen, Eefje J A" uniqKey="Schrauwen E" first="Eefje J. A." last="Schrauwen">Eefje J. A. Schrauwen</name><name sortKey="Short, Kirsty R" sort="Short, Kirsty R" uniqKey="Short K" first="Kirsty R." last="Short">Kirsty R. Short</name><name sortKey="Siegers, Jurre Y" sort="Siegers, Jurre Y" uniqKey="Siegers J" first="Jurre Y." last="Siegers">Jurre Y. Siegers</name><name sortKey="Spronken, Monique I J" sort="Spronken, Monique I J" uniqKey="Spronken M" first="Monique I. J." last="Spronken">Monique I. J. Spronken</name><name sortKey="Van Riel, Debby" sort="Van Riel, Debby" uniqKey="Van Riel D" first="Debby" last="Van Riel">Debby Van Riel</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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