Novel avian-origin influenza A (H7N9) virus attaches to epithelium in both upper and lower respiratory tract of humans.
Identifieur interne : 000954 ( PubMed/Corpus ); précédent : 000953; suivant : 000955Novel avian-origin influenza A (H7N9) virus attaches to epithelium in both upper and lower respiratory tract of humans.
Auteurs : Debby Van Riel ; Lonneke M E. Leijten ; Miranda De Graaf ; Jurre Y. Siegers ; Kirsty R. Short ; Monique I J. Spronken ; Eefje J A. Schrauwen ; Ron A M. Fouchier ; Albert D M E. Osterhaus ; Thijs KuikenSource :
- The American journal of pathology [ 1525-2191 ] ; 2013.
English descriptors
- KwdEn :
- Adult, Aged, Animals, Epithelium (pathology), Epithelium (virology), Erythrocytes (metabolism), Hemagglutination Tests, Hemagglutinin Glycoproteins, Influenza Virus (metabolism), Humans, Influenza A Virus, H7N9 Subtype (physiology), Influenza in Birds (virology), Influenza, Human (virology), Middle Aged, Reassortant Viruses, Receptors, Virus (metabolism), Respiratory System (pathology), Respiratory System (virology), Turkeys, Virus Attachment, Young Adult.
- MESH :
- chemical , metabolism : Hemagglutinin Glycoproteins, Influenza Virus, Receptors, Virus.
- metabolism : Erythrocytes.
- pathology : Epithelium, Respiratory System.
- physiology : Influenza A Virus, H7N9 Subtype.
- virology : Epithelium, Influenza in Birds, Influenza, Human, Respiratory System.
- Adult, Aged, Animals, Hemagglutination Tests, Humans, Middle Aged, Reassortant Viruses, Turkeys, Virus Attachment, Young Adult.
Abstract
Influenza A viruses from animal reservoirs have the capacity to adapt to humans and cause influenza pandemics. The occurrence of an influenza pandemic requires efficient virus transmission among humans, which is associated with virus attachment to the upper respiratory tract. Pandemic severity depends on virus ability to cause pneumonia, which is associated with virus attachment to the lower respiratory tract. Recently, a novel avian-origin H7N9 influenza A virus with unknown pandemic potential emerged in humans. We determined the pattern of attachment of two genetically engineered viruses containing the hemagglutinin of either influenza virus A/Shanghai/1/13 or A/Anhui/1/13 to formalin-fixed human respiratory tract tissues using histochemical analysis. Our results show that the emerging H7N9 virus attached moderately or abundantly to both upper and lower respiratory tract, a pattern not seen before for avian influenza A viruses. With the caveat that virus attachment is only the first step in the virus replication cycle, these results suggest that the emerging H7N9 virus has the potential both to transmit efficiently among humans and to cause severe pneumonia.
DOI: 10.1016/j.ajpath.2013.06.011
PubMed: 24029490
Links to Exploration step
pubmed:24029490Le document en format XML
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Leijten</name><affiliation><nlm:affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Graaf, Miranda" sort="De Graaf, Miranda" uniqKey="De Graaf M" first="Miranda" last="De Graaf">Miranda De Graaf</name><affiliation><nlm:affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Siegers, Jurre Y" sort="Siegers, Jurre Y" uniqKey="Siegers J" first="Jurre Y" last="Siegers">Jurre Y. Siegers</name><affiliation><nlm:affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Short, Kirsty R" sort="Short, Kirsty R" uniqKey="Short K" first="Kirsty R" last="Short">Kirsty R. Short</name><affiliation><nlm:affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Spronken, Monique I J" sort="Spronken, Monique I J" uniqKey="Spronken M" first="Monique I J" last="Spronken">Monique I J. Spronken</name><affiliation><nlm:affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Schrauwen, Eefje J A" sort="Schrauwen, Eefje J A" uniqKey="Schrauwen E" first="Eefje J A" last="Schrauwen">Eefje J A. Schrauwen</name><affiliation><nlm:affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name><affiliation><nlm:affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name><affiliation><nlm:affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><affiliation><nlm:affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands. Electronic address: t.kuiken@erasmusmc.nl.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The American journal of pathology</title><idno type="eISSN">1525-2191</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Animals</term><term>Epithelium (pathology)</term><term>Epithelium (virology)</term><term>Erythrocytes (metabolism)</term><term>Hemagglutination Tests</term><term>Hemagglutinin Glycoproteins, Influenza Virus (metabolism)</term><term>Humans</term><term>Influenza A Virus, H7N9 Subtype (physiology)</term><term>Influenza in Birds (virology)</term><term>Influenza, Human (virology)</term><term>Middle Aged</term><term>Reassortant Viruses</term><term>Receptors, Virus (metabolism)</term><term>Respiratory System (pathology)</term><term>Respiratory System (virology)</term><term>Turkeys</term><term>Virus Attachment</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Erythrocytes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Epithelium</term><term>Respiratory System</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H7N9 Subtype</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Epithelium</term><term>Influenza in Birds</term><term>Influenza, Human</term><term>Respiratory System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Animals</term><term>Hemagglutination Tests</term><term>Humans</term><term>Middle Aged</term><term>Reassortant Viruses</term><term>Turkeys</term><term>Virus Attachment</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza A viruses from animal reservoirs have the capacity to adapt to humans and cause influenza pandemics. The occurrence of an influenza pandemic requires efficient virus transmission among humans, which is associated with virus attachment to the upper respiratory tract. Pandemic severity depends on virus ability to cause pneumonia, which is associated with virus attachment to the lower respiratory tract. Recently, a novel avian-origin H7N9 influenza A virus with unknown pandemic potential emerged in humans. We determined the pattern of attachment of two genetically engineered viruses containing the hemagglutinin of either influenza virus A/Shanghai/1/13 or A/Anhui/1/13 to formalin-fixed human respiratory tract tissues using histochemical analysis. Our results show that the emerging H7N9 virus attached moderately or abundantly to both upper and lower respiratory tract, a pattern not seen before for avian influenza A viruses. With the caveat that virus attachment is only the first step in the virus replication cycle, these results suggest that the emerging H7N9 virus has the potential both to transmit efficiently among humans and to cause severe pneumonia. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24029490</PMID><DateCompleted><Year>2014</Year><Month>04</Month><Day>22</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1525-2191</ISSN><JournalIssue CitedMedium="Internet"><Volume>183</Volume><Issue>4</Issue><PubDate><Year>2013</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The American journal of pathology</Title><ISOAbbreviation>Am. J. Pathol.</ISOAbbreviation></Journal><ArticleTitle>Novel avian-origin influenza A (H7N9) virus attaches to epithelium in both upper and lower respiratory tract of humans.</ArticleTitle><Pagination><MedlinePgn>1137-1143</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0002-9440(13)00457-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ajpath.2013.06.011</ELocationID><Abstract><AbstractText>Influenza A viruses from animal reservoirs have the capacity to adapt to humans and cause influenza pandemics. The occurrence of an influenza pandemic requires efficient virus transmission among humans, which is associated with virus attachment to the upper respiratory tract. Pandemic severity depends on virus ability to cause pneumonia, which is associated with virus attachment to the lower respiratory tract. Recently, a novel avian-origin H7N9 influenza A virus with unknown pandemic potential emerged in humans. We determined the pattern of attachment of two genetically engineered viruses containing the hemagglutinin of either influenza virus A/Shanghai/1/13 or A/Anhui/1/13 to formalin-fixed human respiratory tract tissues using histochemical analysis. Our results show that the emerging H7N9 virus attached moderately or abundantly to both upper and lower respiratory tract, a pattern not seen before for avian influenza A viruses. With the caveat that virus attachment is only the first step in the virus replication cycle, these results suggest that the emerging H7N9 virus has the potential both to transmit efficiently among humans and to cause severe pneumonia. </AbstractText><CopyrightInformation>Copyright © 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van Riel</LastName><ForeName>Debby</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leijten</LastName><ForeName>Lonneke M E</ForeName><Initials>LME</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Graaf</LastName><ForeName>Miranda</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siegers</LastName><ForeName>Jurre Y</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Short</LastName><ForeName>Kirsty R</ForeName><Initials>KR</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spronken</LastName><ForeName>Monique I J</ForeName><Initials>MIJ</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schrauwen</LastName><ForeName>Eefje J A</ForeName><Initials>EJA</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fouchier</LastName><ForeName>Ron A M</ForeName><Initials>RAM</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Osterhaus</LastName><ForeName>Albert D M E</ForeName><Initials>ADME</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuiken</LastName><ForeName>Thijs</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Viroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands. Electronic address: t.kuiken@erasmusmc.nl.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>HHSN266200700010C</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN266200700010C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>09</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Pathol</MedlineTA><NlmUniqueID>0370502</NlmUniqueID><ISSNLinking>0002-9440</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011991">Receptors, Virus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004848" MajorTopicYN="N">Epithelium</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004912" MajorTopicYN="N">Erythrocytes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006386" MajorTopicYN="N">Hemagglutination Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064766" MajorTopicYN="N">Influenza A Virus, H7N9 Subtype</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000821" 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| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a PandemieGrippaleV1
| This area was generated with Dilib version V0.6.34. |  |