Early Characterization of the Severity and Transmissibility of Pandemic Influenza Using Clinical Episode Data from Multiple Populations
Identifieur interne : 000B86 ( Main/Exploration ); précédent : 000B85; suivant : 000B87Early Characterization of the Severity and Transmissibility of Pandemic Influenza Using Clinical Episode Data from Multiple Populations
Auteurs : Pete Riley [États-Unis] ; Michal Ben-Nun [États-Unis] ; Jon A. Linker [États-Unis] ; Angelia A. Cost [États-Unis] ; Jose L. Sanchez [États-Unis] ; Dylan George [États-Unis] ; David P. Bacon [États-Unis] ; Steven Riley [États-Unis, Royaume-Uni]Source :
- PLoS Computational Biology [ 1553-734X ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- épidémiologie : Grippe humaine.
- Bases de données factuelles, Biologie informatique, Humains, Modèles biologiques, Pandémies.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Influenza, Human.
- methods : Computational Biology.
- prevention & control : Pandemics.
- statistics & numerical data : Pandemics.
- transmission : Influenza, Human.
- Databases, Factual, Humans, Models, Biological.
Abstract
The potential rapid availability of large-scale clinical episode data during the next influenza pandemic suggests an opportunity for increasing the speed with which novel respiratory pathogens can be characterized. Key intervention decisions will be determined by both the transmissibility of the novel strain (measured by the basic reproductive number
Url:
DOI: 10.1371/journal.pcbi.1004392
PubMed: 26402446
PubMed Central: 4581836
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>The potential rapid availability of large-scale clinical episode data during the next influenza pandemic suggests an opportunity for increasing the speed with which novel respiratory pathogens can be characterized. Key intervention decisions will be determined by both the transmissibility of the novel strain (measured by the basic reproductive number <italic>R</italic>
<sub>0</sub>
) and its individual-level severity. The 2009 pandemic illustrated that estimating individual-level severity, as described by the proportion <italic>p</italic>
<sub><italic>C</italic>
</sub>
of infections that result in clinical cases, can remain uncertain for a prolonged period of time. Here, we use 50 distinct US military populations during 2009 as a retrospective cohort to test the hypothesis that real-time encounter data combined with disease dynamic models can be used to bridge this uncertainty gap. Effectively, we estimated the total number of infections in multiple early-affected communities using the model and divided that number by the known number of clinical cases. Joint estimates of severity and transmissibility clustered within a relatively small region of parameter space, with 40 of the 50 populations bounded by: <italic>p</italic>
<sub><italic>C</italic>
</sub>
, 0.0133–0.150 and <italic>R</italic>
<sub>0</sub>
, 1.09–2.16. These fits were obtained despite widely varying incidence profiles: some with spring waves, some with fall waves and some with both. To illustrate the benefit of specific pairing of rapidly available data and infectious disease models, we simulated a future moderate pandemic strain with <italic>p</italic>
<sub><italic>C</italic>
</sub>
approximately ×10 that of 2009; the results demonstrating that even before the peak had passed in the first affected population, <italic>R</italic>
<sub>0</sub>
and <italic>p</italic>
<sub><italic>C</italic>
</sub>
could be well estimated. This study provides a clear reference in this two-dimensional space against which future novel respiratory pathogens can be rapidly assessed and compared with previous pandemics.</p>
</div>
</front>
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</author>
<author><name sortKey="Costanzo, M" uniqKey="Costanzo M">M Costanzo</name>
</author>
<author><name sortKey="Fey, P" uniqKey="Fey P">P Fey</name>
</author>
<author><name sortKey="Gojobori, T" uniqKey="Gojobori T">T Gojobori</name>
</author>
<author><name sortKey="Hannick, L" uniqKey="Hannick L">L Hannick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hay, Si" uniqKey="Hay S">SI Hay</name>
</author>
<author><name sortKey="George, Db" uniqKey="George D">DB George</name>
</author>
<author><name sortKey="Moyes, Cl" uniqKey="Moyes C">CL Moyes</name>
</author>
<author><name sortKey="Brownstein, Js" uniqKey="Brownstein J">JS Brownstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heffernan, R" uniqKey="Heffernan R">R Heffernan</name>
</author>
<author><name sortKey="Mostashari, F" uniqKey="Mostashari F">F Mostashari</name>
</author>
<author><name sortKey="Das, D" uniqKey="Das D">D Das</name>
</author>
<author><name sortKey="Karpati, A" uniqKey="Karpati A">A Karpati</name>
</author>
<author><name sortKey="Kulldorff, M" uniqKey="Kulldorff M">M Kulldorff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ginsberg, M" uniqKey="Ginsberg M">M Ginsberg</name>
</author>
<author><name sortKey="Hopkins, J" uniqKey="Hopkins J">J Hopkins</name>
</author>
<author><name sortKey="Maroufi, A" uniqKey="Maroufi A">A Maroufi</name>
</author>
<author><name sortKey="Dunne, G" uniqKey="Dunne G">G Dunne</name>
</author>
<author><name sortKey="Sunega, D" uniqKey="Sunega D">D Sunega</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, R" uniqKey="Gao R">R Gao</name>
</author>
<author><name sortKey="Cao, B" uniqKey="Cao B">B Cao</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name>
</author>
<author><name sortKey="Feng, Z" uniqKey="Feng Z">Z Feng</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name>
</author>
<author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name>
</author>
<author><name sortKey="Heffernan, Rt" uniqKey="Heffernan R">RT Heffernan</name>
</author>
<author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name>
</author>
<author><name sortKey="Redd" uniqKey="Redd">Redd</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name>
</author>
<author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name>
</author>
<author><name sortKey="Ghani, Ac" uniqKey="Ghani A">AC Ghani</name>
</author>
<author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Jt" uniqKey="Wu J">JT Wu</name>
</author>
<author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name>
</author>
<author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name>
</author>
<author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Newall, At" uniqKey="Newall A">AT Newall</name>
</author>
<author><name sortKey="Wood, Jg" uniqKey="Wood J">JG Wood</name>
</author>
<author><name sortKey="Oudin, N" uniqKey="Oudin N">N Oudin</name>
</author>
<author><name sortKey="Macintyre, Cr" uniqKey="Macintyre C">CR MacIntyre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nichol, Kl" uniqKey="Nichol K">KL Nichol</name>
</author>
<author><name sortKey="Treanor, Jj" uniqKey="Treanor J">JJ Treanor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heesterbeek, Ja" uniqKey="Heesterbeek J">JA Heesterbeek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name>
</author>
<author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name>
</author>
<author><name sortKey="Hanage, Wp" uniqKey="Hanage W">WP Hanage</name>
</author>
<author><name sortKey="Van Kerkhove, Md" uniqKey="Van Kerkhove M">MD Van Kerkhove</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mills, Ce" uniqKey="Mills C">CE Mills</name>
</author>
<author><name sortKey="Robins, Jm" uniqKey="Robins J">JM Robins</name>
</author>
<author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Kerkhove, Md" uniqKey="Van Kerkhove M">MD van Kerkhove</name>
</author>
<author><name sortKey="Asikainen, T" uniqKey="Asikainen T">T Asikainen</name>
</author>
<author><name sortKey="Becker, Ng" uniqKey="Becker N">NG Becker</name>
</author>
<author><name sortKey="Bjorge, S" uniqKey="Bjorge S">S Bjorge</name>
</author>
<author><name sortKey="Desenclos, Jc" uniqKey="Desenclos J">JC Desenclos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name>
</author>
<author><name sortKey="Cummings, Da" uniqKey="Cummings D">DA Cummings</name>
</author>
<author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name>
</author>
<author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name>
</author>
<author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Longini, Im" uniqKey="Longini I">IM Longini</name>
</author>
<author><name sortKey="Nizam, A" uniqKey="Nizam A">A Nizam</name>
</author>
<author><name sortKey="Xu, S" uniqKey="Xu S">S Xu</name>
</author>
<author><name sortKey="Ungchusak, K" uniqKey="Ungchusak K">K Ungchusak</name>
</author>
<author><name sortKey="Hanshaoworakul, W" uniqKey="Hanshaoworakul W">W Hanshaoworakul</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, Jy" uniqKey="Wong J">JY Wong</name>
</author>
<author><name sortKey="Wu, P" uniqKey="Wu P">P Wu</name>
</author>
<author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H Nishiura</name>
</author>
<author><name sortKey="Goldstein, E" uniqKey="Goldstein E">E Goldstein</name>
</author>
<author><name sortKey="Lau, Eh" uniqKey="Lau E">EH Lau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name>
</author>
<author><name sortKey="Kwok, Ko" uniqKey="Kwok K">KO Kwok</name>
</author>
<author><name sortKey="Wu, Km" uniqKey="Wu K">KM Wu</name>
</author>
<author><name sortKey="Ning, Dy" uniqKey="Ning D">DY Ning</name>
</author>
<author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Olson, Dr" uniqKey="Olson D">DR Olson</name>
</author>
<author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name>
</author>
<author><name sortKey="Edelson, Pj" uniqKey="Edelson P">PJ Edelson</name>
</author>
<author><name sortKey="Morse, Ss" uniqKey="Morse S">SS Morse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Kerkhove, Md" uniqKey="Van Kerkhove M">MD Van Kerkhove</name>
</author>
<author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name>
</author>
<author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Monto, As" uniqKey="Monto A">AS Monto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morse, Ss" uniqKey="Morse S">SS Morse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reed, C" uniqKey="Reed C">C Reed</name>
</author>
<author><name sortKey="Biggerstaff, M" uniqKey="Biggerstaff M">M Biggerstaff</name>
</author>
<author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name>
</author>
<author><name sortKey="Koonin, Lm" uniqKey="Koonin L">LM Koonin</name>
</author>
<author><name sortKey="Beauvais, D" uniqKey="Beauvais D">D Beauvais</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Riley, P" uniqKey="Riley P">P Riley</name>
</author>
<author><name sortKey="Ben Nun, M" uniqKey="Ben Nun M">M Ben-Nun</name>
</author>
<author><name sortKey="Armenta, R" uniqKey="Armenta R">R Armenta</name>
</author>
<author><name sortKey="Linker, Ja" uniqKey="Linker J">JA Linker</name>
</author>
<author><name sortKey="Eick, Aa" uniqKey="Eick A">AA Eick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marsden Haug, N" uniqKey="Marsden Haug N">N Marsden-Haug</name>
</author>
<author><name sortKey="Foster, Vb" uniqKey="Foster V">VB Foster</name>
</author>
<author><name sortKey="Gould, Pl" uniqKey="Gould P">PL Gould</name>
</author>
<author><name sortKey="Elbert, E" uniqKey="Elbert E">E Elbert</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gilks, W" uniqKey="Gilks W">W Gilks</name>
</author>
<author><name sortKey="Richardson, S" uniqKey="Richardson S">S Richardson</name>
</author>
<author><name sortKey="Spiegelhalter, D" uniqKey="Spiegelhalter D">D Spiegelhalter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fleming, Dm" uniqKey="Fleming D">DM Fleming</name>
</author>
<author><name sortKey="Elliot, Aj" uniqKey="Elliot A">AJ Elliot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fisman, Dn" uniqKey="Fisman D">DN Fisman</name>
</author>
<author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name>
</author>
<author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, W" uniqKey="Yang W">W Yang</name>
</author>
<author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name>
</author>
<author><name sortKey="Shaman, J" uniqKey="Shaman J">J Shaman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anderson, Sj" uniqKey="Anderson S">SJ Anderson</name>
</author>
<author><name sortKey="Cherutich, P" uniqKey="Cherutich P">P Cherutich</name>
</author>
<author><name sortKey="Kilonzo, N" uniqKey="Kilonzo N">N Kilonzo</name>
</author>
<author><name sortKey="Cremin, I" uniqKey="Cremin I">I Cremin</name>
</author>
<author><name sortKey="Fecht, D" uniqKey="Fecht D">D Fecht</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reed, C" uniqKey="Reed C">C Reed</name>
</author>
<author><name sortKey="Angulo, Fj" uniqKey="Angulo F">FJ Angulo</name>
</author>
<author><name sortKey="Swerdlow, Dl" uniqKey="Swerdlow D">DL Swerdlow</name>
</author>
<author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name>
</author>
<author><name sortKey="Meltzer, Mi" uniqKey="Meltzer M">MI Meltzer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name>
</author>
<author><name sortKey="Spreeuwenberg, P" uniqKey="Spreeuwenberg P">P Spreeuwenberg</name>
</author>
<author><name sortKey="Lustig, R" uniqKey="Lustig R">R Lustig</name>
</author>
<author><name sortKey="Taylor, Rj" uniqKey="Taylor R">RJ Taylor</name>
</author>
<author><name sortKey="Fleming, Dm" uniqKey="Fleming D">DM Fleming</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shaman, J" uniqKey="Shaman J">J Shaman</name>
</author>
<author><name sortKey="Karspeck, A" uniqKey="Karspeck A">A Karspeck</name>
</author>
</analytic>
</biblStruct>
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