Early vaccine availability represents an important public health advance for the control of pandemic influenza
Identifieur interne : 000B85 ( Main/Exploration ); précédent : 000B84; suivant : 000B86Early vaccine availability represents an important public health advance for the control of pandemic influenza
Auteurs : Amy L. GreerSource :
- BMC Research Notes [ 1756-0500 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Canada (épidémiologie), Enfant, Enfant d'âge préscolaire, Grippe humaine (), Grippe humaine (immunologie), Grippe humaine (épidémiologie), Humains, Jeune adulte, Modèles biologiques, Nourrisson, Nouveau-né, Pandémies (), Plantes, Résultat thérapeutique, Saisons, Santé publique, Sujet âgé, Vaccination, Vaccins antigrippaux (immunologie).
- MESH :
- immunologie : Grippe humaine, Vaccins antigrippaux.
- épidémiologie : Canada, Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Grippe humaine, Humains, Jeune adulte, Modèles biologiques, Nourrisson, Nouveau-né, Pandémies, Plantes, Résultat thérapeutique, Saisons, Santé publique, Sujet âgé, Vaccination.
- Wicri :
- geographic : Canada.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Canada (epidemiology), Child, Child, Preschool, Humans, Infant, Infant, Newborn, Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (prevention & control), Middle Aged, Models, Biological, Pandemics (prevention & control), Plants, Public Health, Seasons, Treatment Outcome, Vaccination, Young Adult.
- MESH :
- chemical , immunology : Influenza Vaccines.
- geographic , epidemiology : Canada.
- epidemiology : Influenza, Human.
- immunology : Influenza, Human.
- prevention & control : Influenza, Human, Pandemics.
- Adolescent, Adult, Aged, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Middle Aged, Models, Biological, Plants, Public Health, Seasons, Treatment Outcome, Vaccination, Young Adult.
Abstract
Traditional processes for the production of pandemic influenza vaccines are not capable of producing a vaccine that could be deployed sooner than 5–6 months after strain identification. Plant-based vaccine technologies are of public health interest because they represent an opportunity to begin vaccinating earlier.
We used an age- and risk- structured disease transmission model for Canada to evaluate the potential impact of a plant-produced vaccine available for rapid deployment (within 1–3 months) compared to an egg-based vaccine timeline.
We found that in the case of a mildly transmissible virus (
Pandemic influenza vaccines produced by plants, change the timeline of pandemic vaccine availability in a way that could significantly mitigate the impact of the next influenza pandemic.
Url:
DOI: 10.1186/s13104-015-1157-1
PubMed: 25953076
PubMed Central: 4427977
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Traditional processes for the production of pandemic influenza vaccines are not capable of producing a vaccine that could be deployed sooner than 5–6 months after strain identification. Plant-based vaccine technologies are of public health interest because they represent an opportunity to begin vaccinating earlier.</p>
</sec>
<sec><title>Methods</title>
<p>We used an age- and risk- structured disease transmission model for Canada to evaluate the potential impact of a plant-produced vaccine available for rapid deployment (within 1–3 months) compared to an egg-based vaccine timeline.</p>
</sec>
<sec><title>Results</title>
<p>We found that in the case of a mildly transmissible virus (<italic>R0</italic>
= 1.3), depending on the amount of plant-based vaccine produced per week, severe clinical outcomes could be decreased by 60–100 % if vaccine was available within 3 months of strain identification. However, in the case of a highly transmissible virus (<italic>R0</italic>
= 2.0), a delay of 3 months does not change clinical outcomes regardless of the level of weekly vaccine availability. If transmissibility is high, the only strategy that can impact clinical outcomes occurs if vaccine production is high and available within 2 months.</p>
</sec>
<sec><title>Conclusions</title>
<p>Pandemic influenza vaccines produced by plants, change the timeline of pandemic vaccine availability in a way that could significantly mitigate the impact of the next influenza pandemic.</p>
</sec>
</div>
</front>
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