Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection
Identifieur interne : 001786 ( Main/Curation ); précédent : 001785; suivant : 001787Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection
Auteurs : Irina L. Tutykhina [Russie] ; Elena S. Sedova [Russie] ; Irina Y. Gribova [Russie] ; Tatiana I. Ivanova [Russie] ; Lev A. Vasilev [Russie] ; Marina V. Rutovskaya [Russie] ; Andrei A. Lysenko [Russie] ; Maxim M. Shmarov [Russie] ; Denis Y. Logunov [Russie] ; Boris S. Naroditsky [Russie] ; Sergei V. Tillib [Russie] ; Alexander L. Gintsburg [Russie]Source :
- Antiviral research [ 0166-3542 ] ; 2013.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
One effective method for the prevention and treatment of influenza infection is passive immunization. In our study, we examined the feasibility of creating an antibody-based preparation with a prolonged protective effect against influenza virus. Single-domain antibodies (sdAbs) specific for influenza virus hem-agglutinin were generated. Experiments in mouse models showed 100% survivability for both intranasal sdAbs administration 24 h prior to influenza challenge and 24 h after infection. sdAb-gene delivery by an adenoviral vector led to gene expression for up to 14 days. Protection by a recombinant adenovirus containing the sdAb gene was observed in cases of administration prior to influenza infection (14 d-24 h). We also demonstrated that the single administration of a combined preparation containing sdAb DNA and protein expanded the protection time window from 14 d prior to 48 h after influenza infection. This approach and the application of a broad-spectrum sdAbs will allow the development of efficient drugs for the prevention and treatment of viral infections produced by pandemic virus variants and other infections.
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Pascal:13-0152042Le document en format XML
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<term>Influenza</term>
<term>Influenzavirus</term>
<term>Mouse</term>
<term>Passive immunization</term>
<term>Prevention</term>
<term>Vector</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Immunisation passive</term>
<term>Adenoviridae</term>
<term>Adénovirus humain</term>
<term>Anticorps</term>
<term>Prévention</term>
<term>Animal</term>
<term>Souris</term>
<term>Grippe</term>
<term>Influenzavirus</term>
<term>Vecteur</term>
<term>Forme fatale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">One effective method for the prevention and treatment of influenza infection is passive immunization. In our study, we examined the feasibility of creating an antibody-based preparation with a prolonged protective effect against influenza virus. Single-domain antibodies (sdAbs) specific for influenza virus hem-agglutinin were generated. Experiments in mouse models showed 100% survivability for both intranasal sdAbs administration 24 h prior to influenza challenge and 24 h after infection. sdAb-gene delivery by an adenoviral vector led to gene expression for up to 14 days. Protection by a recombinant adenovirus containing the sdAb gene was observed in cases of administration prior to influenza infection (14 d-24 h). We also demonstrated that the single administration of a combined preparation containing sdAb DNA and protein expanded the protection time window from 14 d prior to 48 h after influenza infection. This approach and the application of a broad-spectrum sdAbs will allow the development of efficient drugs for the prevention and treatment of viral infections produced by pandemic virus variants and other infections.</div>
</front>
</TEI>
</record>
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