Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection
Identifieur interne : 001813 ( Main/Merge ); précédent : 001812; suivant : 001814Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection
Auteurs : Irina L. Tutykhina [Russie] ; Elena S. Sedova [Russie] ; Irina Y. Gribova [Russie] ; Tatiana I. Ivanova [Russie] ; Lev A. Vasilev [Russie] ; Marina V. Rutovskaya [Russie] ; Andrei A. Lysenko [Russie] ; Maxim M. Shmarov [Russie] ; Denis Y. Logunov [Russie] ; Boris S. Naroditsky [Russie] ; Sergei V. Tillib [Russie] ; Alexander L. Gintsburg [Russie]Source :
- Antiviral research [ 0166-3542 ] ; 2013.
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Abstract
One effective method for the prevention and treatment of influenza infection is passive immunization. In our study, we examined the feasibility of creating an antibody-based preparation with a prolonged protective effect against influenza virus. Single-domain antibodies (sdAbs) specific for influenza virus hem-agglutinin were generated. Experiments in mouse models showed 100% survivability for both intranasal sdAbs administration 24 h prior to influenza challenge and 24 h after infection. sdAb-gene delivery by an adenoviral vector led to gene expression for up to 14 days. Protection by a recombinant adenovirus containing the sdAb gene was observed in cases of administration prior to influenza infection (14 d-24 h). We also demonstrated that the single administration of a combined preparation containing sdAb DNA and protein expanded the protection time window from 14 d prior to 48 h after influenza infection. This approach and the application of a broad-spectrum sdAbs will allow the development of efficient drugs for the prevention and treatment of viral infections produced by pandemic virus variants and other infections.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection</title><author><name sortKey="Tutykhina, Irina L" sort="Tutykhina, Irina L" uniqKey="Tutykhina I" first="Irina L." last="Tutykhina">Irina L. Tutykhina</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Sedova, Elena S" sort="Sedova, Elena S" uniqKey="Sedova E" first="Elena S." last="Sedova">Elena S. Sedova</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Gribova, Irina Y" sort="Gribova, Irina Y" uniqKey="Gribova I" first="Irina Y." last="Gribova">Irina Y. Gribova</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Ivanova, Tatiana I" sort="Ivanova, Tatiana I" uniqKey="Ivanova T" first="Tatiana I." last="Ivanova">Tatiana I. Ivanova</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1><s2>Moscow 119334</s2><s3>RUS</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Vasilev, Lev A" sort="Vasilev, Lev A" uniqKey="Vasilev L" first="Lev A." last="Vasilev">Lev A. Vasilev</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1><s2>Moscow 119334</s2><s3>RUS</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Rutovskaya, Marina V" sort="Rutovskaya, Marina V" uniqKey="Rutovskaya M" first="Marina V." last="Rutovskaya">Marina V. Rutovskaya</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1><s2>Moscow 119334</s2><s3>RUS</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Lysenko, Andrei A" sort="Lysenko, Andrei A" uniqKey="Lysenko A" first="Andrei A." last="Lysenko">Andrei A. Lysenko</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Shmarov, Maxim M" sort="Shmarov, Maxim M" uniqKey="Shmarov M" first="Maxim M." last="Shmarov">Maxim M. Shmarov</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Logunov, Denis Y" sort="Logunov, Denis Y" uniqKey="Logunov D" first="Denis Y." last="Logunov">Denis Y. Logunov</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Naroditsky, Boris S" sort="Naroditsky, Boris S" uniqKey="Naroditsky B" first="Boris S." last="Naroditsky">Boris S. Naroditsky</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Tillib, Sergei V" sort="Tillib, Sergei V" uniqKey="Tillib S" first="Sergei V." last="Tillib">Sergei V. Tillib</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1><s2>Moscow 119334</s2><s3>RUS</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Gintsburg, Alexander L" sort="Gintsburg, Alexander L" uniqKey="Gintsburg A" first="Alexander L." last="Gintsburg">Alexander L. Gintsburg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0152042</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0152042 INIST</idno><idno type="RBID">Pascal:13-0152042</idno><idno type="wicri:Area/PascalFrancis/Corpus">000312</idno><idno type="wicri:Area/PascalFrancis/Curation">001B14</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000216</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000216</idno><idno type="wicri:doubleKey">0166-3542:2013:Tutykhina I:passive:immunization:with</idno><idno type="wicri:Area/Main/Merge">001813</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection</title><author><name sortKey="Tutykhina, Irina L" sort="Tutykhina, Irina L" uniqKey="Tutykhina I" first="Irina L." last="Tutykhina">Irina L. Tutykhina</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Sedova, Elena S" sort="Sedova, Elena S" uniqKey="Sedova E" first="Elena S." last="Sedova">Elena S. Sedova</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Gribova, Irina Y" sort="Gribova, Irina Y" uniqKey="Gribova I" first="Irina Y." last="Gribova">Irina Y. Gribova</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Ivanova, Tatiana I" sort="Ivanova, Tatiana I" uniqKey="Ivanova T" first="Tatiana I." last="Ivanova">Tatiana I. Ivanova</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1><s2>Moscow 119334</s2><s3>RUS</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Vasilev, Lev A" sort="Vasilev, Lev A" uniqKey="Vasilev L" first="Lev A." last="Vasilev">Lev A. Vasilev</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1><s2>Moscow 119334</s2><s3>RUS</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Rutovskaya, Marina V" sort="Rutovskaya, Marina V" uniqKey="Rutovskaya M" first="Marina V." last="Rutovskaya">Marina V. Rutovskaya</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1><s2>Moscow 119334</s2><s3>RUS</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Lysenko, Andrei A" sort="Lysenko, Andrei A" uniqKey="Lysenko A" first="Andrei A." last="Lysenko">Andrei A. Lysenko</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Shmarov, Maxim M" sort="Shmarov, Maxim M" uniqKey="Shmarov M" first="Maxim M." last="Shmarov">Maxim M. Shmarov</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Logunov, Denis Y" sort="Logunov, Denis Y" uniqKey="Logunov D" first="Denis Y." last="Logunov">Denis Y. Logunov</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Naroditsky, Boris S" sort="Naroditsky, Boris S" uniqKey="Naroditsky B" first="Boris S." last="Naroditsky">Boris S. Naroditsky</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Tillib, Sergei V" sort="Tillib, Sergei V" uniqKey="Tillib S" first="Sergei V." last="Tillib">Sergei V. Tillib</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1><s2>Moscow 119334</s2><s3>RUS</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Gintsburg, Alexander L" sort="Gintsburg, Alexander L" uniqKey="Gintsburg A" first="Alexander L." last="Gintsburg">Alexander L. Gintsburg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1><s2>Moscow 123098</s2><s3>RUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Russie</country><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Antiviral research</title><title level="j" type="abbreviated">Antivir. res.</title><idno type="ISSN">0166-3542</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Antiviral research</title><title level="j" type="abbreviated">Antivir. res.</title><idno type="ISSN">0166-3542</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae</term><term>Animal</term><term>Antibody</term><term>Human adenovirus</term><term>Influenza</term><term>Influenzavirus</term><term>Mouse</term><term>Passive immunization</term><term>Prevention</term><term>Vector</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Immunisation passive</term><term>Adenoviridae</term><term>Adénovirus humain</term><term>Anticorps</term><term>Prévention</term><term>Animal</term><term>Souris</term><term>Grippe</term><term>Influenzavirus</term><term>Vecteur</term><term>Forme fatale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One effective method for the prevention and treatment of influenza infection is passive immunization. In our study, we examined the feasibility of creating an antibody-based preparation with a prolonged protective effect against influenza virus. Single-domain antibodies (sdAbs) specific for influenza virus hem-agglutinin were generated. Experiments in mouse models showed 100% survivability for both intranasal sdAbs administration 24 h prior to influenza challenge and 24 h after infection. sdAb-gene delivery by an adenoviral vector led to gene expression for up to 14 days. Protection by a recombinant adenovirus containing the sdAb gene was observed in cases of administration prior to influenza infection (14 d-24 h). We also demonstrated that the single administration of a combined preparation containing sdAb DNA and protein expanded the protection time window from 14 d prior to 48 h after influenza infection. This approach and the application of a broad-spectrum sdAbs will allow the development of efficient drugs for the prevention and treatment of viral infections produced by pandemic virus variants and other infections.</div></front></TEI><affiliations><list><country><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Tutykhina, Irina L" sort="Tutykhina, Irina L" uniqKey="Tutykhina I" first="Irina L." last="Tutykhina">Irina L. Tutykhina</name></region><name sortKey="Gintsburg, Alexander L" sort="Gintsburg, Alexander L" uniqKey="Gintsburg A" first="Alexander L." last="Gintsburg">Alexander L. Gintsburg</name><name sortKey="Gribova, Irina Y" sort="Gribova, Irina Y" uniqKey="Gribova I" first="Irina Y." last="Gribova">Irina Y. Gribova</name><name sortKey="Ivanova, Tatiana I" sort="Ivanova, Tatiana I" uniqKey="Ivanova T" first="Tatiana I." last="Ivanova">Tatiana I. Ivanova</name><name sortKey="Logunov, Denis Y" sort="Logunov, Denis Y" uniqKey="Logunov D" first="Denis Y." last="Logunov">Denis Y. Logunov</name><name sortKey="Lysenko, Andrei A" sort="Lysenko, Andrei A" uniqKey="Lysenko A" first="Andrei A." last="Lysenko">Andrei A. Lysenko</name><name sortKey="Naroditsky, Boris S" sort="Naroditsky, Boris S" uniqKey="Naroditsky B" first="Boris S." last="Naroditsky">Boris S. Naroditsky</name><name sortKey="Rutovskaya, Marina V" sort="Rutovskaya, Marina V" uniqKey="Rutovskaya M" first="Marina V." last="Rutovskaya">Marina V. Rutovskaya</name><name sortKey="Sedova, Elena S" sort="Sedova, Elena S" uniqKey="Sedova E" first="Elena S." last="Sedova">Elena S. Sedova</name><name sortKey="Shmarov, Maxim M" sort="Shmarov, Maxim M" uniqKey="Shmarov M" first="Maxim M." last="Shmarov">Maxim M. Shmarov</name><name sortKey="Tillib, Sergei V" sort="Tillib, Sergei V" uniqKey="Tillib S" first="Sergei V." last="Tillib">Sergei V. Tillib</name><name sortKey="Vasilev, Lev A" sort="Vasilev, Lev A" uniqKey="Vasilev L" first="Lev A." last="Vasilev">Lev A. Vasilev</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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