PandemieGrippaleV1, PascalFrancis, Curation, bibRecord, 001B14

Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection

Identifieur interne : 001B14 ( PascalFrancis/Curation ); précédent : 001B13; suivant : 001B15

Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection

Auteurs : Irina L. Tutykhina [Russie] ; Elena S. Sedova [Russie] ; Irina Y. Gribova [Russie] ; Tatiana I. Ivanova [Russie] ; Lev A. Vasilev [Russie] ; Marina V. Rutovskaya [Russie] ; Andrei A. Lysenko [Russie] ; Maxim M. Shmarov [Russie] ; Denis Y. Logunov [Russie] ; Boris S. Naroditsky [Russie] ; Sergei V. Tillib [Russie] ; Alexander L. Gintsburg [Russie]

Source :

Antiviral research [ 0166-3542 ] ; 2013.

RBID : Pascal:13-0152042

Descripteurs français

Pascal (Inist)
- Immunisation passive, Adenoviridae, Adénovirus humain, Anticorps, Prévention, Animal, Souris, Grippe, Influenzavirus, Vecteur, Forme fatale.

English descriptors

KwdEn :
- Adenoviridae, Animal, Antibody, Human adenovirus, Influenza, Influenzavirus, Mouse, Passive immunization, Prevention, Vector.

Abstract

One effective method for the prevention and treatment of influenza infection is passive immunization. In our study, we examined the feasibility of creating an antibody-based preparation with a prolonged protective effect against influenza virus. Single-domain antibodies (sdAbs) specific for influenza virus hem-agglutinin were generated. Experiments in mouse models showed 100% survivability for both intranasal sdAbs administration 24 h prior to influenza challenge and 24 h after infection. sdAb-gene delivery by an adenoviral vector led to gene expression for up to 14 days. Protection by a recombinant adenovirus containing the sdAb gene was observed in cases of administration prior to influenza infection (14 d-24 h). We also demonstrated that the single administration of a combined preparation containing sdAb DNA and protein expanded the protection time window from 14 d prior to 48 h after influenza infection. This approach and the application of a broad-spectrum sdAbs will allow the development of efficient drugs for the prevention and treatment of viral infections produced by pandemic virus variants and other infections.

A01	`01`	`1`		`@0 0166-3542`
A02	`01`			`@0 ARSRDR`
A03		`1`		`@0 Antivir. res.`
A05				`@2 97`
A06				`@2 3`
A08	`01`	`1`	`ENG`	`@1 Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection`
A11	`01`	`1`		`@1 TUTYKHINA (Irina L.)`
A11	`02`	`1`		`@1 SEDOVA (Elena S.)`
A11	`03`	`1`		`@1 GRIBOVA (Irina Y.)`
A11	`04`	`1`		`@1 IVANOVA (Tatiana I.)`
A11	`05`	`1`		`@1 VASILEV (Lev A.)`
A11	`06`	`1`		`@1 RUTOVSKAYA (Marina V.)`
A11	`07`	`1`		`@1 LYSENKO (Andrei A.)`
A11	`08`	`1`		`@1 SHMAROV (Maxim M.)`
A11	`09`	`1`		`@1 LOGUNOV (Denis Y.)`
A11	`10`	`1`		`@1 NARODITSKY (Boris S.)`
A11	`11`	`1`		`@1 TILLIB (Sergei V.)`
A11	`12`	`1`		`@1 GINTSBURG (Alexander L.)`
A14	`01`			`@1 Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street @2 Moscow 123098 @3 RUS @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut. @Z 10 aut. @Z 12 aut.`
A14	`02`			`@1 Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street @2 Moscow 119334 @3 RUS @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 11 aut.`
A20				`@1 318-328`
A21				`@1 2013`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 18839 @5 354000503745790140`
A44				`@0 0000 @1 © 2013 INIST-CNRS. All rights reserved.`
A45				`@0 1 p.1/4`
A47	`01`	`1`		`@0 13-0152042`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Antiviral research`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 One effective method for the prevention and treatment of influenza infection is passive immunization. In our study, we examined the feasibility of creating an antibody-based preparation with a prolonged protective effect against influenza virus. Single-domain antibodies (sdAbs) specific for influenza virus hem-agglutinin were generated. Experiments in mouse models showed 100% survivability for both intranasal sdAbs administration 24 h prior to influenza challenge and 24 h after infection. sdAb-gene delivery by an adenoviral vector led to gene expression for up to 14 days. Protection by a recombinant adenovirus containing the sdAb gene was observed in cases of administration prior to influenza infection (14 d-24 h). We also demonstrated that the single administration of a combined preparation containing sdAb DNA and protein expanded the protection time window from 14 d prior to 48 h after influenza infection. This approach and the application of a broad-spectrum sdAbs will allow the development of efficient drugs for the prevention and treatment of viral infections produced by pandemic virus variants and other infections.
C02	`01`	`X`		`@0 002B02S05`
C02	`02`	`X`		`@0 002B05C02C`
C03	`01`	`X`	`FRE`	`@0 Immunisation passive @5 01`
C03	`01`	`X`	`ENG`	`@0 Passive immunization @5 01`
C03	`01`	`X`	`SPA`	`@0 Inmunización pasiva @5 01`
C03	`02`	`X`	`FRE`	`@0 Adenoviridae @2 NW @5 02`
C03	`02`	`X`	`ENG`	`@0 Adenoviridae @2 NW @5 02`
C03	`02`	`X`	`SPA`	`@0 Adenoviridae @2 NW @5 02`
C03	`03`	`X`	`FRE`	`@0 Adénovirus humain @2 NW @5 03`
C03	`03`	`X`	`ENG`	`@0 Human adenovirus @2 NW @5 03`
C03	`03`	`X`	`SPA`	`@0 Human adenovirus @2 NW @5 03`
C03	`04`	`X`	`FRE`	`@0 Anticorps @5 04`
C03	`04`	`X`	`ENG`	`@0 Antibody @5 04`
C03	`04`	`X`	`SPA`	`@0 Anticuerpo @5 04`
C03	`05`	`X`	`FRE`	`@0 Prévention @5 05`
C03	`05`	`X`	`ENG`	`@0 Prevention @5 05`
C03	`05`	`X`	`SPA`	`@0 Prevención @5 05`
C03	`06`	`X`	`FRE`	`@0 Animal @5 06`
C03	`06`	`X`	`ENG`	`@0 Animal @5 06`
C03	`06`	`X`	`SPA`	`@0 Animal @5 06`
C03	`07`	`X`	`FRE`	`@0 Souris @5 07`
C03	`07`	`X`	`ENG`	`@0 Mouse @5 07`
C03	`07`	`X`	`SPA`	`@0 Ratón @5 07`
C03	`08`	`X`	`FRE`	`@0 Grippe @5 08`
C03	`08`	`X`	`ENG`	`@0 Influenza @5 08`
C03	`08`	`X`	`SPA`	`@0 Gripe @5 08`
C03	`09`	`X`	`FRE`	`@0 Influenzavirus @2 NW @5 10`
C03	`09`	`X`	`ENG`	`@0 Influenzavirus @2 NW @5 10`
C03	`09`	`X`	`SPA`	`@0 Influenzavirus @2 NW @5 10`
C03	`10`	`X`	`FRE`	`@0 Vecteur @5 11`
C03	`10`	`X`	`ENG`	`@0 Vector @5 11`
C03	`10`	`X`	`SPA`	`@0 Vector @5 11`
C03	`11`	`X`	`FRE`	`@0 Forme fatale @4 INC @5 86`
C07	`01`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`01`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`01`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`02`	`X`	`FRE`	`@0 Mastadenovirus @2 NW`
C07	`02`	`X`	`ENG`	`@0 Mastadenovirus @2 NW`
C07	`02`	`X`	`SPA`	`@0 Mastadenovirus @2 NW`
C07	`03`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`03`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`03`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`04`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`04`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`04`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`05`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`05`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`05`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`06`	`X`	`FRE`	`@0 Virose`
C07	`06`	`X`	`ENG`	`@0 Viral disease`
C07	`06`	`X`	`SPA`	`@0 Virosis`
C07	`07`	`X`	`FRE`	`@0 Infection`
C07	`07`	`X`	`ENG`	`@0 Infection`
C07	`07`	`X`	`SPA`	`@0 Infección`
C07	`08`	`X`	`FRE`	`@0 Orthomyxoviridae @2 NW`
C07	`08`	`X`	`ENG`	`@0 Orthomyxoviridae @2 NW`
C07	`08`	`X`	`SPA`	`@0 Orthomyxoviridae @2 NW`
N21				`@1 125`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000312

Links to Exploration step

Pascal:13-0152042

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection</title>
<author><name sortKey="Tutykhina, Irina L" sort="Tutykhina, Irina L" uniqKey="Tutykhina I" first="Irina L." last="Tutykhina">Irina L. Tutykhina</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Sedova, Elena S" sort="Sedova, Elena S" uniqKey="Sedova E" first="Elena S." last="Sedova">Elena S. Sedova</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Gribova, Irina Y" sort="Gribova, Irina Y" uniqKey="Gribova I" first="Irina Y." last="Gribova">Irina Y. Gribova</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Ivanova, Tatiana I" sort="Ivanova, Tatiana I" uniqKey="Ivanova T" first="Tatiana I." last="Ivanova">Tatiana I. Ivanova</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1>
<s2>Moscow 119334</s2>
<s3>RUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Vasilev, Lev A" sort="Vasilev, Lev A" uniqKey="Vasilev L" first="Lev A." last="Vasilev">Lev A. Vasilev</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1>
<s2>Moscow 119334</s2>
<s3>RUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Rutovskaya, Marina V" sort="Rutovskaya, Marina V" uniqKey="Rutovskaya M" first="Marina V." last="Rutovskaya">Marina V. Rutovskaya</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1>
<s2>Moscow 119334</s2>
<s3>RUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Lysenko, Andrei A" sort="Lysenko, Andrei A" uniqKey="Lysenko A" first="Andrei A." last="Lysenko">Andrei A. Lysenko</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Shmarov, Maxim M" sort="Shmarov, Maxim M" uniqKey="Shmarov M" first="Maxim M." last="Shmarov">Maxim M. Shmarov</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Logunov, Denis Y" sort="Logunov, Denis Y" uniqKey="Logunov D" first="Denis Y." last="Logunov">Denis Y. Logunov</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Naroditsky, Boris S" sort="Naroditsky, Boris S" uniqKey="Naroditsky B" first="Boris S." last="Naroditsky">Boris S. Naroditsky</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Tillib, Sergei V" sort="Tillib, Sergei V" uniqKey="Tillib S" first="Sergei V." last="Tillib">Sergei V. Tillib</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1>
<s2>Moscow 119334</s2>
<s3>RUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Gintsburg, Alexander L" sort="Gintsburg, Alexander L" uniqKey="Gintsburg A" first="Alexander L." last="Gintsburg">Alexander L. Gintsburg</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">13-0152042</idno>
<date when="2013">2013</date>
<idno type="stanalyst">PASCAL 13-0152042 INIST</idno>
<idno type="RBID">Pascal:13-0152042</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000312</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001B14</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection</title>
<author><name sortKey="Tutykhina, Irina L" sort="Tutykhina, Irina L" uniqKey="Tutykhina I" first="Irina L." last="Tutykhina">Irina L. Tutykhina</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Sedova, Elena S" sort="Sedova, Elena S" uniqKey="Sedova E" first="Elena S." last="Sedova">Elena S. Sedova</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Gribova, Irina Y" sort="Gribova, Irina Y" uniqKey="Gribova I" first="Irina Y." last="Gribova">Irina Y. Gribova</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Ivanova, Tatiana I" sort="Ivanova, Tatiana I" uniqKey="Ivanova T" first="Tatiana I." last="Ivanova">Tatiana I. Ivanova</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1>
<s2>Moscow 119334</s2>
<s3>RUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Vasilev, Lev A" sort="Vasilev, Lev A" uniqKey="Vasilev L" first="Lev A." last="Vasilev">Lev A. Vasilev</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1>
<s2>Moscow 119334</s2>
<s3>RUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Rutovskaya, Marina V" sort="Rutovskaya, Marina V" uniqKey="Rutovskaya M" first="Marina V." last="Rutovskaya">Marina V. Rutovskaya</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1>
<s2>Moscow 119334</s2>
<s3>RUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Lysenko, Andrei A" sort="Lysenko, Andrei A" uniqKey="Lysenko A" first="Andrei A." last="Lysenko">Andrei A. Lysenko</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Shmarov, Maxim M" sort="Shmarov, Maxim M" uniqKey="Shmarov M" first="Maxim M." last="Shmarov">Maxim M. Shmarov</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Logunov, Denis Y" sort="Logunov, Denis Y" uniqKey="Logunov D" first="Denis Y." last="Logunov">Denis Y. Logunov</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Naroditsky, Boris S" sort="Naroditsky, Boris S" uniqKey="Naroditsky B" first="Boris S." last="Naroditsky">Boris S. Naroditsky</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Tillib, Sergei V" sort="Tillib, Sergei V" uniqKey="Tillib S" first="Sergei V." last="Tillib">Sergei V. Tillib</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1>
<s2>Moscow 119334</s2>
<s3>RUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
<author><name sortKey="Gintsburg, Alexander L" sort="Gintsburg, Alexander L" uniqKey="Gintsburg A" first="Alexander L." last="Gintsburg">Alexander L. Gintsburg</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Russie</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Antiviral research</title>
<title level="j" type="abbreviated">Antivir. res.</title>
<idno type="ISSN">0166-3542</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Antiviral research</title>
<title level="j" type="abbreviated">Antivir. res.</title>
<idno type="ISSN">0166-3542</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae</term>
<term>Animal</term>
<term>Antibody</term>
<term>Human adenovirus</term>
<term>Influenza</term>
<term>Influenzavirus</term>
<term>Mouse</term>
<term>Passive immunization</term>
<term>Prevention</term>
<term>Vector</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Immunisation passive</term>
<term>Adenoviridae</term>
<term>Adénovirus humain</term>
<term>Anticorps</term>
<term>Prévention</term>
<term>Animal</term>
<term>Souris</term>
<term>Grippe</term>
<term>Influenzavirus</term>
<term>Vecteur</term>
<term>Forme fatale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">One effective method for the prevention and treatment of influenza infection is passive immunization. In our study, we examined the feasibility of creating an antibody-based preparation with a prolonged protective effect against influenza virus. Single-domain antibodies (sdAbs) specific for influenza virus hem-agglutinin were generated. Experiments in mouse models showed 100% survivability for both intranasal sdAbs administration 24 h prior to influenza challenge and 24 h after infection. sdAb-gene delivery by an adenoviral vector led to gene expression for up to 14 days. Protection by a recombinant adenovirus containing the sdAb gene was observed in cases of administration prior to influenza infection (14 d-24 h). We also demonstrated that the single administration of a combined preparation containing sdAb DNA and protein expanded the protection time window from 14 d prior to 48 h after influenza infection. This approach and the application of a broad-spectrum sdAbs will allow the development of efficient drugs for the prevention and treatment of viral infections produced by pandemic virus variants and other infections.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0166-3542</s0>
</fA01>
<fA02 i1="01"><s0>ARSRDR</s0>
</fA02>
<fA03 i2="1"><s0>Antivir. res.</s0>
</fA03>
<fA05><s2>97</s2>
</fA05>
<fA06><s2>3</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>TUTYKHINA (Irina L.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>SEDOVA (Elena S.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>GRIBOVA (Irina Y.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>IVANOVA (Tatiana I.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>VASILEV (Lev A.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>RUTOVSKAYA (Marina V.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>LYSENKO (Andrei A.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>SHMAROV (Maxim M.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>LOGUNOV (Denis Y.)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>NARODITSKY (Boris S.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>TILLIB (Sergei V.)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>GINTSBURG (Alexander L.)</s1>
</fA11>
<fA14 i1="01"><s1>Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street</s1>
<s2>Moscow 123098</s2>
<s3>RUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Institute of Gene Biology, Russian Academy of Sciences, 34/5, Vavilova Street</s1>
<s2>Moscow 119334</s2>
<s3>RUS</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA20><s1>318-328</s1>
</fA20>
<fA21><s1>2013</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>18839</s2>
<s5>354000503745790140</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2013 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>1 p.1/4</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>13-0152042</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Antiviral research</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>One effective method for the prevention and treatment of influenza infection is passive immunization. In our study, we examined the feasibility of creating an antibody-based preparation with a prolonged protective effect against influenza virus. Single-domain antibodies (sdAbs) specific for influenza virus hem-agglutinin were generated. Experiments in mouse models showed 100% survivability for both intranasal sdAbs administration 24 h prior to influenza challenge and 24 h after infection. sdAb-gene delivery by an adenoviral vector led to gene expression for up to 14 days. Protection by a recombinant adenovirus containing the sdAb gene was observed in cases of administration prior to influenza infection (14 d-24 h). We also demonstrated that the single administration of a combined preparation containing sdAb DNA and protein expanded the protection time window from 14 d prior to 48 h after influenza infection. This approach and the application of a broad-spectrum sdAbs will allow the development of efficient drugs for the prevention and treatment of viral infections produced by pandemic virus variants and other infections.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02S05</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05C02C</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Immunisation passive</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Passive immunization</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Inmunización pasiva</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Adenoviridae</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Adenoviridae</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Adenoviridae</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Adénovirus humain</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Human adenovirus</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Human adenovirus</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Anticorps</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Antibody</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Anticuerpo</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Prévention</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Prevention</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Prevención</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Animal</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Animal</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Animal</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Souris</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Mouse</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Ratón</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Grippe</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Influenza</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Gripe</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Influenzavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Influenzavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Influenzavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Vecteur</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Vector</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Vector</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Forme fatale</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Mastadenovirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Mastadenovirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Mastadenovirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fN21><s1>125</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/PascalFrancis/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B14 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 001B14 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    PandemieGrippaleV1
   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:13-0152042
   |texte=   Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection
}}

This area was generated with Dilib version V0.6.34.
Data generation: Wed Jun 10 11:04:28 2020. Site generation: Sun Mar 28 09:10:28 2021

	Serveur d'exploration sur les pandémies grippales
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les pandémies grippales

Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection

Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri