Alpha‐synuclein immunohistochemistry in two cases of co‐occurring idiopathic Parkinson's disease and motor neuron disease
Identifieur interne : 005117 ( Main/Merge ); précédent : 005116; suivant : 005118Alpha‐synuclein immunohistochemistry in two cases of co‐occurring idiopathic Parkinson's disease and motor neuron disease
Auteurs : Kevin J. Klos [États-Unis] ; Keith A. Josephs [États-Unis] ; Joseph E. Parisi [États-Unis] ; Dennis W. Dickson [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-11.
English descriptors
- KwdEn :
- Aged, Brain (metabolism), Brain (pathology), Female, Humans, Immunohistochemistry (methods), Lewy bodies, Male, Motor Neuron Disease (complications), Motor Neuron Disease (metabolism), Motor Neuron Disease (pathology), Neurofilament Proteins (metabolism), Parkinson Disease (complications), Parkinson Disease (metabolism), Parkinson Disease (pathology), Ubiquitin (metabolism), alpha-Synuclein (metabolism), argyrophilic grain disease, motor neuron disease, sporadic idiopathic Parkinson's disease.
- MESH :
- chemical , metabolism : Neurofilament Proteins, Ubiquitin, alpha-Synuclein.
- complications : Motor Neuron Disease, Parkinson Disease.
- metabolism : Brain, Motor Neuron Disease, Parkinson Disease.
- methods : Immunohistochemistry.
- pathology : Brain, Motor Neuron Disease, Parkinson Disease.
- Aged, Female, Humans, Male.
Abstract
We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co‐occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20604
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<front><div type="abstract" xml:lang="en">We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co‐occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration. © 2005 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co-occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration.</div>
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