MovDisordV3, PubMed, Corpus, bibRecord, 002F75

Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.

Identifieur interne : 002F75 ( PubMed/Corpus ); précédent : 002F74; suivant : 002F76

Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.

Auteurs : Kevin J. Klos ; Keith A. Josephs ; Joseph E. Parisi ; Dennis W. Dickson

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.

RBID : pubmed:16035099

English descriptors

KwdEn :
- Aged, Brain (metabolism), Brain (pathology), Female, Humans, Immunohistochemistry (methods), Male, Motor Neuron Disease (complications), Motor Neuron Disease (metabolism), Motor Neuron Disease (pathology), Neurofilament Proteins (metabolism), Parkinson Disease (complications), Parkinson Disease (metabolism), Parkinson Disease (pathology), Ubiquitin (metabolism), alpha-Synuclein (metabolism).
MESH :
- chemical , metabolism : Neurofilament Proteins, Ubiquitin, alpha-Synuclein.
- complications : Motor Neuron Disease, Parkinson Disease.
- metabolism : Brain, Motor Neuron Disease, Parkinson Disease.
- methods : Immunohistochemistry.
- pathology : Brain, Motor Neuron Disease, Parkinson Disease.
- Aged, Female, Humans, Male.

Abstract

We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co-occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration.

DOI: 10.1002/mds.20604
PubMed: 16035099

Links to Exploration step

pubmed:16035099

Le document en format XML

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<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J" last="Klos">Kevin J. Klos</name>
<affiliation><nlm:affiliation>Department of Neurology, Movement Disorder Division, Mayo Clinic, Rochester, Minnesota, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E" last="Parisi">Joseph E. Parisi</name>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.</title>
<author><name sortKey="Klos, Kevin J" sort="Klos, Kevin J" uniqKey="Klos K" first="Kevin J" last="Klos">Kevin J. Klos</name>
<affiliation><nlm:affiliation>Department of Neurology, Movement Disorder Division, Mayo Clinic, Rochester, Minnesota, USA.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A" last="Josephs">Keith A. Josephs</name>
</author>
<author><name sortKey="Parisi, Joseph E" sort="Parisi, Joseph E" uniqKey="Parisi J" first="Joseph E" last="Parisi">Joseph E. Parisi</name>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Brain (metabolism)</term>
<term>Brain (pathology)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry (methods)</term>
<term>Male</term>
<term>Motor Neuron Disease (complications)</term>
<term>Motor Neuron Disease (metabolism)</term>
<term>Motor Neuron Disease (pathology)</term>
<term>Neurofilament Proteins (metabolism)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Ubiquitin (metabolism)</term>
<term>alpha-Synuclein (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Neurofilament Proteins</term>
<term>Ubiquitin</term>
<term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Motor Neuron Disease</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term>
<term>Motor Neuron Disease</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunohistochemistry</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Motor Neuron Disease</term>
<term>Parkinson Disease</term>
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<front><div type="abstract" xml:lang="en">We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co-occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration.</div>
</front>
</TEI>
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<DateCreated><Year>2005</Year>
<Month>11</Month>
<Day>02</Day>
</DateCreated>
<DateCompleted><Year>2006</Year>
<Month>02</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2007</Year>
<Month>04</Month>
<Day>05</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN>
<JournalIssue CitedMedium="Print"><Volume>20</Volume>
<Issue>11</Issue>
<PubDate><Year>2005</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.</ArticleTitle>
<Pagination><MedlinePgn>1515-20</MedlinePgn>
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<Abstract><AbstractText>We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co-occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Klos</LastName>
<ForeName>Kevin J</ForeName>
<Initials>KJ</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Movement Disorder Division, Mayo Clinic, Rochester, Minnesota, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Josephs</LastName>
<ForeName>Keith A</ForeName>
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</Author>
<Author ValidYN="Y"><LastName>Parisi</LastName>
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<Author ValidYN="Y"><LastName>Dickson</LastName>
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<Language>eng</Language>
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<MedlineJournalInfo><Country>United States</Country>
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<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Mov Disord. 2007 Jan;22(1):151-2</RefSource>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D016900">Neurofilament Proteins</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
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<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D025801">Ubiquitin</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D051844">alpha-Synuclein</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year>
<Month>7</Month>
<Day>22</Day>
<Hour>9</Hour>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.

Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki