Alpha‐synuclein mRNA expression in sporadic Parkinson's disease
Identifieur interne : 005116 ( Main/Merge ); précédent : 005115; suivant : 005117Alpha‐synuclein mRNA expression in sporadic Parkinson's disease
Auteurs : Eng-King Tan [Singapour] ; Van R. Chandran [Singapour] ; Stephanie Fook-Chong [Singapour] ; Hui Shen [Singapour] ; Kenneth Yew [Singapour] ; Mei-Lin Teoh [Singapour] ; Yih Yuen [Singapour] ; Yi Zhao [Singapour]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-05.
English descriptors
- KwdEn :
- DNA Primers (genetics), Female, Gene Expression (genetics), Humans, Male, Middle Aged, Multivariate Analysis, Mutation, Missense (genetics), Nerve Tissue Proteins (genetics), Parkinson Disease (genetics), Parkinson's disease, Polymerase Chain Reaction, RNA, Messenger (genetics), Synucleins, alpha-Synuclein, alpha‐synuclein, gene dosage, mRNA.
- MESH :
- chemical , genetics : DNA Primers, Nerve Tissue Proteins, RNA, Messenger.
- genetics : Gene Expression, Mutation, Missense, Parkinson Disease.
- Female, Humans, Male, Middle Aged, Multivariate Analysis, Polymerase Chain Reaction, Synucleins, alpha-Synuclein.
Abstract
The expression of α‐synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median [range] 0.110 ]0.012–0.628] vs. 0.120 [0.028–0.447]; P = 0.15). There was no difference in the α‐synuclein gene dosage between PD patients with high and low mRNA expression. Multivariate analysis did not reveal age, gender, or cigarette smoking as confounding variables. Our study suggests that there was no significant alteration of α‐synuclein mRNA expression in our sporadic PD patients compared to controls. However, the role of α‐synuclein mRNA expression in select groups of sporadic PD patients and its interaction with environmental agents need to be further determined. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20391
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<front><div type="abstract" xml:lang="en">The expression of α‐synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median [range] 0.110 ]0.012–0.628] vs. 0.120 [0.028–0.447]; P = 0.15). There was no difference in the α‐synuclein gene dosage between PD patients with high and low mRNA expression. Multivariate analysis did not reveal age, gender, or cigarette smoking as confounding variables. Our study suggests that there was no significant alteration of α‐synuclein mRNA expression in our sporadic PD patients compared to controls. However, the role of α‐synuclein mRNA expression in select groups of sporadic PD patients and its interaction with environmental agents need to be further determined. © 2005 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">The expression of α‐synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median [range] 0.110 ]0.012–0.628] vs. 0.120 [0.028–0.447]; P = 0.15). There was no difference in the α‐synuclein gene dosage between PD patients with high and low mRNA expression. Multivariate analysis did not reveal age, gender, or cigarette smoking as confounding variables. Our study suggests that there was no significant alteration of α‐synuclein mRNA expression in our sporadic PD patients compared to controls. However, the role of α‐synuclein mRNA expression in select groups of sporadic PD patients and its interaction with environmental agents need to be further determined. © 2005 Movement Disorder Society</div>
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<author><name sortKey="Teoh, Mei Lin" sort="Teoh, Mei Lin" uniqKey="Teoh M" first="Mei-Lin" last="Teoh">Mei-Lin Teoh</name>
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<author><name sortKey="Yuen, Yih" sort="Yuen, Yih" uniqKey="Yuen Y" first="Yih" last="Yuen">Yih Yuen</name>
</author>
<author><name sortKey="Zhao, Yi" sort="Zhao, Yi" uniqKey="Zhao Y" first="Yi" last="Zhao">Yi Zhao</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2005" type="published">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DNA Primers (genetics)</term>
<term>Female</term>
<term>Gene Expression (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Mutation, Missense (genetics)</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymerase Chain Reaction</term>
<term>RNA, Messenger (genetics)</term>
<term>Synucleins</term>
<term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA Primers</term>
<term>Nerve Tissue Proteins</term>
<term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Expression</term>
<term>Mutation, Missense</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Polymerase Chain Reaction</term>
<term>Synucleins</term>
<term>alpha-Synuclein</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The expression of alpha-synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real-time polymerase chain reaction techniques, we demonstrated that the alpha-synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median [range] 0.110 ]0.012-0.628] vs. 0.120 [0.028-0.447]; P = 0.15). There was no difference in the alpha-synuclein gene dosage between PD patients with high and low mRNA expression. Multivariate analysis did not reveal age, gender, or cigarette smoking as confounding variables. Our study suggests that there was no significant alteration of alpha-synuclein mRNA expression in our sporadic PD patients compared to controls. However, the role of alpha-synuclein mRNA expression in select groups of sporadic PD patients and its interaction with environmental agents need to be further determined.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
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