Gender differences in the association between antidepressant use and restless legs syndrome
Identifieur interne : 002292 ( Main/Exploration ); précédent : 002291; suivant : 002293Gender differences in the association between antidepressant use and restless legs syndrome
Auteurs : Kristin R. Baughman [États-Unis] ; Claire C. Bourguet [États-Unis] ; Scott K. Ober [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-05-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antidepressive Agents (adverse effects), Antidepressive Agents (classification), Depression, Female, Humans, Male, Middle Aged, Nervous system diseases, Observation, Primary Health Care (statistics & numerical data), Regression Analysis, Restless Legs Syndrome (chemically induced), Restless legs syndrome, Risk Factors, Sex, Sex Characteristics, Veterans, Young Adult, antidepressants, depression, gender, restless legs syndrome.
- MESH :
- chemical , adverse effects : Antidepressive Agents.
- chemical , classification : Antidepressive Agents.
- chemically induced : Restless Legs Syndrome.
- statistics & numerical data : Primary Health Care.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Observation, Regression Analysis, Risk Factors, Sex Characteristics, Veterans, Young Adult.
Abstract
Contradictory results have been reported for the association between antidepressant use and Restless Legs Syndrome (RLS). Our aim was to clarify the relationship and examine possible gender differences. We interviewed 1,693 veterans receiving primary care from the Cleveland VA Medical Center and obtained prescription drug information from their medical records. Overall, use of an antidepressant was associated with RLS for men (RR = 1.77, CI = 1.26, 2.48) but not for women (RR = 0.79, CI = 0.43, 1.47). Analyses of individual antidepressants revealed an association between RLS and fluoxetine for women (RR = 2.47, CI = 1.33, 4.56), and associations between RLS and citalopram, (RR = 2.09, CI = 1.20, 3.64), paroxetine (RR = 1.97, CI = 1.02, 3.79), and amitriptyline (RR = 2.40, CI = 1.45, 4.00) for men. We conclude that RLS may be associated with antidepressant use, but the association varies by gender and type of antidepressant. Antidepressant use is more strongly associated with RLS in men than in women. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22517
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Contradictory results have been reported for the association between antidepressant use and Restless Legs Syndrome (RLS). Our aim was to clarify the relationship and examine possible gender differences. We interviewed 1,693 veterans receiving primary care from the Cleveland VA Medical Center and obtained prescription drug information from their medical records. Overall, use of an antidepressant was associated with RLS for men (RR = 1.77, CI = 1.26, 2.48) but not for women (RR = 0.79, CI = 0.43, 1.47). Analyses of individual antidepressants revealed an association between RLS and fluoxetine for women (RR = 2.47, CI = 1.33, 4.56), and associations between RLS and citalopram, (RR = 2.09, CI = 1.20, 3.64), paroxetine (RR = 1.97, CI = 1.02, 3.79), and amitriptyline (RR = 2.40, CI = 1.45, 4.00) for men. We conclude that RLS may be associated with antidepressant use, but the association varies by gender and type of antidepressant. Antidepressant use is more strongly associated with RLS in men than in women. © 2009 Movement Disorder Society</div>
</front>
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