Gender Differences in the Association Between Antidepressant Use and Restless Legs Syndrome
Identifieur interne : 002F62 ( Main/Merge ); précédent : 002F61; suivant : 002F63Gender Differences in the Association Between Antidepressant Use and Restless Legs Syndrome
Auteurs : Kristin R. Baughman [États-Unis] ; Claire C. Bourguet [États-Unis] ; Scott K. Ober [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Contradictory results have been reported for the association between antidepressant use and Restless Legs Syndrome (RLS). Our aim was to clarify the relationship and examine possible gender differences. We interviewed 1,693 veterans receiving primary care from the Cleveland VA Medical Center and obtained prescription drug information from their medical records. Overall, use of an antidepressant was associated with RLS for men (RR = 1.77, CI = 1.26, 2.48) but not for women (RR = 0.79, CI = 0.43, 1.47). Analyses of individual antidepressants revealed an association between RLS and fluoxetine for women (RR = 2.47, CI = 1.33, 4.56), and associations between RLS and citalopram, (RR = 2.09, CI = 1.20, 3.64), paroxetine (RR = 1.97, CI = 1.02, 3.79), and amitriptyline (RR = 2.40, CI = 1.45, 4.00) for men. We conclude that RLS may be associated with antidepressant use, but the association varies by gender and type of antidepressant. Antidepressant use is more strongly associated with RLS in men than in women.
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Bourguet</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Behavioral and Community Health Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy</s1><s2>Rootstown, Ohio</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Ober, Scott K" sort="Ober, Scott K" uniqKey="Ober S" first="Scott K." last="Ober">Scott K. Ober</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Community Outpatient Services, Louis B. 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Baughman</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Behavioral and Community Health Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy</s1><s2>Rootstown, Ohio</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Bourguet, Claire C" sort="Bourguet, Claire C" uniqKey="Bourguet C" first="Claire C." last="Bourguet">Claire C. Bourguet</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Behavioral and Community Health Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy</s1><s2>Rootstown, Ohio</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Ober, Scott K" sort="Ober, Scott K" uniqKey="Ober S" first="Scott K." last="Ober">Scott K. Ober</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Community Outpatient Services, Louis B. Stokes Cleveland Veterans Affairs Medical Center</s1><s2>Cleveland, Ohio</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Medicine, Case Western Reserve University, School of Medicine</s1><s2>Cleveland, Ohio</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Depression</term><term>Nervous system diseases</term><term>Restless legs syndrome</term><term>Sex</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Syndrome des jambes sans repos</term><term>Etat dépressif</term><term>Pathologie du système nerveux</term><term>Sexe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Contradictory results have been reported for the association between antidepressant use and Restless Legs Syndrome (RLS). Our aim was to clarify the relationship and examine possible gender differences. We interviewed 1,693 veterans receiving primary care from the Cleveland VA Medical Center and obtained prescription drug information from their medical records. Overall, use of an antidepressant was associated with RLS for men (RR = 1.77, CI = 1.26, 2.48) but not for women (RR = 0.79, CI = 0.43, 1.47). Analyses of individual antidepressants revealed an association between RLS and fluoxetine for women (RR = 2.47, CI = 1.33, 4.56), and associations between RLS and citalopram, (RR = 2.09, CI = 1.20, 3.64), paroxetine (RR = 1.97, CI = 1.02, 3.79), and amitriptyline (RR = 2.40, CI = 1.45, 4.00) for men. We conclude that RLS may be associated with antidepressant use, but the association varies by gender and type of antidepressant. Antidepressant use is more strongly associated with RLS in men than in women.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Baughman, Kristin R" sort="Baughman, Kristin R" uniqKey="Baughman K" first="Kristin R." last="Baughman">Kristin R. Baughman</name></region><name sortKey="Bourguet, Claire C" sort="Bourguet, Claire C" uniqKey="Bourguet C" first="Claire C." last="Bourguet">Claire C. Bourguet</name><name sortKey="Ober, Scott K" sort="Ober, Scott K" uniqKey="Ober S" first="Scott K." last="Ober">Scott K. Ober</name><name sortKey="Ober, Scott K" sort="Ober, Scott K" uniqKey="Ober S" first="Scott K." last="Ober">Scott K. Ober</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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