Gender differences in the association between antidepressant use and restless legs syndrome.
Identifieur interne : 002609 ( Ncbi/Checkpoint ); précédent : 002608; suivant : 002610Gender differences in the association between antidepressant use and restless legs syndrome.
Auteurs : Kristin R. Baughman [États-Unis] ; Claire C. Bourguet ; Scott K. OberSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antidepressive Agents (adverse effects), Antidepressive Agents (classification), Female, Humans, Male, Middle Aged, Observation, Primary Health Care (statistics & numerical data), Regression Analysis, Restless Legs Syndrome (chemically induced), Risk Factors, Sex Characteristics, Veterans, Young Adult.
- MESH :
- chemical , adverse effects : Antidepressive Agents.
- chemical , classification : Antidepressive Agents.
- chemically induced : Restless Legs Syndrome.
- statistics & numerical data : Primary Health Care.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Observation, Regression Analysis, Risk Factors, Sex Characteristics, Veterans, Young Adult.
Abstract
Contradictory results have been reported for the association between antidepressant use and Restless Legs Syndrome (RLS). Our aim was to clarify the relationship and examine possible gender differences. We interviewed 1,693 veterans receiving primary care from the Cleveland VA Medical Center and obtained prescription drug information from their medical records. Overall, use of an antidepressant was associated with RLS for men (RR = 1.77, CI = 1.26, 2.48) but not for women (RR = 0.79, CI = 0.43, 1.47). Analyses of individual antidepressants revealed an association between RLS and fluoxetine for women (RR = 2.47, CI = 1.33, 4.56), and associations between RLS and citalopram, (RR = 2.09, CI = 1.20, 3.64), paroxetine (RR = 1.97, CI = 1.02, 3.79), and amitriptyline (RR = 2.40, CI = 1.45, 4.00) for men. We conclude that RLS may be associated with antidepressant use, but the association varies by gender and type of antidepressant. Antidepressant use is more strongly associated with RLS in men than in women.
DOI: 10.1002/mds.22517
PubMed: 19353713
Affiliations:
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Bourguet</name></author><author><name sortKey="Ober, Scott K" sort="Ober, Scott K" uniqKey="Ober S" first="Scott K" last="Ober">Scott K. Ober</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22517</idno><idno type="RBID">pubmed:19353713</idno><idno type="pmid">19353713</idno><idno type="wicri:Area/PubMed/Corpus">001D68</idno><idno type="wicri:Area/PubMed/Curation">001D68</idno><idno type="wicri:Area/PubMed/Checkpoint">001D97</idno><idno type="wicri:Area/Ncbi/Merge">002609</idno><idno type="wicri:Area/Ncbi/Curation">002609</idno><idno type="wicri:Area/Ncbi/Checkpoint">002609</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Gender differences in the association between antidepressant use and restless legs syndrome.</title><author><name sortKey="Baughman, Kristin R" sort="Baughman, Kristin R" uniqKey="Baughman K" first="Kristin R" last="Baughman">Kristin R. Baughman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Behavioral and Community Health Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio 44272, USA. kbaughma@neoucom.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Behavioral and Community Health Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio 44272</wicri:regionArea><wicri:noRegion>Ohio 44272</wicri:noRegion></affiliation></author><author><name sortKey="Bourguet, Claire C" sort="Bourguet, Claire C" uniqKey="Bourguet C" first="Claire C" last="Bourguet">Claire C. Bourguet</name></author><author><name sortKey="Ober, Scott K" sort="Ober, Scott K" uniqKey="Ober S" first="Scott K" last="Ober">Scott K. Ober</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antidepressive Agents (adverse effects)</term><term>Antidepressive Agents (classification)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Observation</term><term>Primary Health Care (statistics & numerical data)</term><term>Regression Analysis</term><term>Restless Legs Syndrome (chemically induced)</term><term>Risk Factors</term><term>Sex Characteristics</term><term>Veterans</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antidepressive Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>Antidepressive Agents</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Primary Health Care</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Observation</term><term>Regression Analysis</term><term>Risk Factors</term><term>Sex Characteristics</term><term>Veterans</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Contradictory results have been reported for the association between antidepressant use and Restless Legs Syndrome (RLS). Our aim was to clarify the relationship and examine possible gender differences. We interviewed 1,693 veterans receiving primary care from the Cleveland VA Medical Center and obtained prescription drug information from their medical records. Overall, use of an antidepressant was associated with RLS for men (RR = 1.77, CI = 1.26, 2.48) but not for women (RR = 0.79, CI = 0.43, 1.47). Analyses of individual antidepressants revealed an association between RLS and fluoxetine for women (RR = 2.47, CI = 1.33, 4.56), and associations between RLS and citalopram, (RR = 2.09, CI = 1.20, 3.64), paroxetine (RR = 1.97, CI = 1.02, 3.79), and amitriptyline (RR = 2.40, CI = 1.45, 4.00) for men. We conclude that RLS may be associated with antidepressant use, but the association varies by gender and type of antidepressant. Antidepressant use is more strongly associated with RLS in men than in women.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Bourguet, Claire C" sort="Bourguet, Claire C" uniqKey="Bourguet C" first="Claire C" last="Bourguet">Claire C. Bourguet</name><name sortKey="Ober, Scott K" sort="Ober, Scott K" uniqKey="Ober S" first="Scott K" last="Ober">Scott K. Ober</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Baughman, Kristin R" sort="Baughman, Kristin R" uniqKey="Baughman K" first="Kristin R" last="Baughman">Kristin R. Baughman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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