Genotype and smoking history affect risk of levodopa‐induced dyskinesias in Parkinson's disease
Identifieur interne : 003422 ( Main/Exploration ); précédent : 003421; suivant : 003423Genotype and smoking history affect risk of levodopa‐induced dyskinesias in Parkinson's disease
Auteurs : Judith A. Strong [États-Unis] ; Arif Dalvi [États-Unis] ; Fredy J. Revilla [États-Unis] ; Alok Sahay [États-Unis] ; Frederick J. Samaha [États-Unis] ; Jeffrey A. Welge [États-Unis] ; Jianhua Gong [États-Unis, Canada] ; Maureen Gartner [États-Unis] ; Xia Yue [États-Unis] ; Lei Yu [États-Unis, Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Tabagisme.
English descriptors
- KwdEn :
- A118G, Adult, Aged, Aged, 80 and over, Antiparkinson Agents (adverse effects), D2 Dopamine receptor, Dyskinesia, Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (genetics), Female, Follow-Up Studies, Genotype, Humans, Levodopa, Levodopa (adverse effects), Male, Middle Aged, Nervous system diseases, Opioid receptor, Parkinson Disease (drug therapy), Parkinson Disease (genetics), Parkinson disease, Polymorphism, Genetic, Receptors, Dopamine (genetics), Receptors, Opioid, mu (genetics), Risk, Risk factor, Smoking, Tobacco smoking, dopamine D2 receptor, dyskinesia, levodopa, mu opioid receptor, smoking.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- genetics : Dyskinesia, Drug-Induced, Parkinson Disease, Receptors, Dopamine, Receptors, Opioid, mu.
- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk, Smoking.
Abstract
Parkinson's disease (PD) patients vary widely in their response to levodopa treatment, and this variation may be partially genetic in origin. We determined whether particular dopamine and opioid receptor polymorphisms were associated with risk of earlier onset of dyskinesia side effects during levodopa therapy. Smoking status was also examined. The 92 subjects were recruited from the movement disorders clinic of a neurology practice associated with a medical school. All were adult‐onset PD patients who had been taking levodopa at least 5 years and/or had developed levodopa‐induced dyskinesia. Carrying the G‐allele of the A118G single nucleotide coding region polymorphism of the mu opioid receptor, as well as a history of never smoking, were independently associated with increased risk of earlier onset of dyskinesia (P = 0.05 and 0.02, respectively). One genotype of the D2 dopamine receptor intronic dinucleotide repeat polymorphism (14 repeats/15 repeats, with frequency of 6%) was also associated with earlier dyskinesia (P = 0.003). History of smoking has previously been associated with reduced risk of developing PD. Our results suggest that smoking history may also influence the response to levodopa, with contribution comparable to those of individual genes including the mu opioid receptor and D2 dopamine receptor. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20785
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001194
- to stream Istex, to step Curation: 001194
- to stream Istex, to step Checkpoint: 001E82
- to stream PubMed, to step Corpus: 002D81
- to stream PubMed, to step Curation: 002D81
- to stream PubMed, to step Checkpoint: 002D13
- to stream Ncbi, to step Merge: 001548
- to stream Ncbi, to step Curation: 001548
- to stream Ncbi, to step Checkpoint: 001548
- to stream Main, to step Merge: 004736
- to stream PascalFrancis, to step Corpus: 001B53
- to stream PascalFrancis, to step Curation: 001168
- to stream PascalFrancis, to step Checkpoint: 001A86
- to stream Main, to step Merge: 004B81
- to stream Main, to step Curation: 003422
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genotype and smoking history affect risk of levodopa‐induced dyskinesias in Parkinson's disease</title><author><name sortKey="Strong, Judith A" sort="Strong, Judith A" uniqKey="Strong J" first="Judith A." last="Strong">Judith A. Strong</name></author><author><name sortKey="Dalvi, Arif" sort="Dalvi, Arif" uniqKey="Dalvi A" first="Arif" last="Dalvi">Arif Dalvi</name></author><author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J." last="Revilla">Fredy J. Revilla</name></author><author><name sortKey="Sahay, Alok" sort="Sahay, Alok" uniqKey="Sahay A" first="Alok" last="Sahay">Alok Sahay</name></author><author><name sortKey="Samaha, Frederick J" sort="Samaha, Frederick J" uniqKey="Samaha F" first="Frederick J." last="Samaha">Frederick J. Samaha</name></author><author><name sortKey="Welge, Jeffrey A" sort="Welge, Jeffrey A" uniqKey="Welge J" first="Jeffrey A." last="Welge">Jeffrey A. Welge</name></author><author><name sortKey="Gong, Jianhua" sort="Gong, Jianhua" uniqKey="Gong J" first="Jianhua" last="Gong">Jianhua Gong</name></author><author><name sortKey="Gartner, Maureen" sort="Gartner, Maureen" uniqKey="Gartner M" first="Maureen" last="Gartner">Maureen Gartner</name></author><author><name sortKey="Yue, Xia" sort="Yue, Xia" uniqKey="Yue X" first="Xia" last="Yue">Xia Yue</name></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:975D26BF86995D19483745B7CE4BD0C660AAF62A</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1002/mds.20785</idno><idno type="url">https://api.istex.fr/document/975D26BF86995D19483745B7CE4BD0C660AAF62A/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001194</idno><idno type="wicri:Area/Istex/Curation">001194</idno><idno type="wicri:Area/Istex/Checkpoint">001E82</idno><idno type="wicri:doubleKey">0885-3185:2006:Strong J:genotype:and:smoking</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:16435402</idno><idno type="wicri:Area/PubMed/Corpus">002D81</idno><idno type="wicri:Area/PubMed/Curation">002D81</idno><idno type="wicri:Area/PubMed/Checkpoint">002D13</idno><idno type="wicri:Area/Ncbi/Merge">001548</idno><idno type="wicri:Area/Ncbi/Curation">001548</idno><idno type="wicri:Area/Ncbi/Checkpoint">001548</idno><idno type="wicri:doubleKey">0885-3185:2006:Strong J:genotype:and:smoking</idno><idno type="wicri:Area/Main/Merge">004736</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:06-0289031</idno><idno type="wicri:Area/PascalFrancis/Corpus">001B53</idno><idno type="wicri:Area/PascalFrancis/Curation">001168</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001A86</idno><idno type="wicri:doubleKey">0885-3185:2006:Strong J:genotype:and:smoking</idno><idno type="wicri:Area/Main/Merge">004B81</idno><idno type="wicri:Area/Main/Curation">003422</idno><idno type="wicri:Area/Main/Exploration">003422</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Genotype and smoking history affect risk of levodopa‐induced dyskinesias in Parkinson's disease</title><author><name sortKey="Strong, Judith A" sort="Strong, Judith A" uniqKey="Strong J" first="Judith A." last="Strong">Judith A. Strong</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Current Address: Department of Anesthesia, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Dalvi, Arif" sort="Dalvi, Arif" uniqKey="Dalvi A" first="Arif" last="Dalvi">Arif Dalvi</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Current Address: Department of Neurology, University of Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J." last="Revilla">Fredy J. Revilla</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Sahay, Alok" sort="Sahay, Alok" uniqKey="Sahay A" first="Alok" last="Sahay">Alok Sahay</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Samaha, Frederick J" sort="Samaha, Frederick J" uniqKey="Samaha F" first="Frederick J." last="Samaha">Frederick J. Samaha</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Welge, Jeffrey A" sort="Welge, Jeffrey A" uniqKey="Welge J" first="Jeffrey A." last="Welge">Jeffrey A. Welge</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Gong, Jianhua" sort="Gong, Jianhua" uniqKey="Gong J" first="Jianhua" last="Gong">Jianhua Gong</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Current Address: Food Research Program, Agriculture and Agri‐Food Canada, Guelph, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Gartner, Maureen" sort="Gartner, Maureen" uniqKey="Gartner M" first="Maureen" last="Gartner">Maureen Gartner</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Yue, Xia" sort="Yue, Xia" uniqKey="Yue X" first="Xia" last="Yue">Xia Yue</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Current Address: Department of Zoology, University of Guelph, Guelph, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-05">2006-05</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="654">654</biblScope><biblScope unit="page" to="659">659</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">975D26BF86995D19483745B7CE4BD0C660AAF62A</idno><idno type="DOI">10.1002/mds.20785</idno><idno type="ArticleID">MDS20785</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A118G</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiparkinson Agents (adverse effects)</term><term>D2 Dopamine receptor</term><term>Dyskinesia</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Dyskinesia, Drug-Induced (genetics)</term><term>Female</term><term>Follow-Up Studies</term><term>Genotype</term><term>Humans</term><term>Levodopa</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Opioid receptor</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (genetics)</term><term>Parkinson disease</term><term>Polymorphism, Genetic</term><term>Receptors, Dopamine (genetics)</term><term>Receptors, Opioid, mu (genetics)</term><term>Risk</term><term>Risk factor</term><term>Smoking</term><term>Tobacco smoking</term><term>dopamine D2 receptor</term><term>dyskinesia</term><term>levodopa</term><term>mu opioid receptor</term><term>smoking</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease</term><term>Receptors, Dopamine</term><term>Receptors, Opioid, mu</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Follow-Up Studies</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Genetic</term><term>Risk</term><term>Smoking</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dyskinésie</term><term>Facteur risque</term><term>Génotype</term><term>Lévodopa</term><term>Parkinson maladie</term><term>Récepteur dopaminergique D2</term><term>Récepteur opiacé</term><term>Système nerveux pathologie</term><term>Tabagisme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Tabagisme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) patients vary widely in their response to levodopa treatment, and this variation may be partially genetic in origin. We determined whether particular dopamine and opioid receptor polymorphisms were associated with risk of earlier onset of dyskinesia side effects during levodopa therapy. Smoking status was also examined. The 92 subjects were recruited from the movement disorders clinic of a neurology practice associated with a medical school. All were adult‐onset PD patients who had been taking levodopa at least 5 years and/or had developed levodopa‐induced dyskinesia. Carrying the G‐allele of the A118G single nucleotide coding region polymorphism of the mu opioid receptor, as well as a history of never smoking, were independently associated with increased risk of earlier onset of dyskinesia (P = 0.05 and 0.02, respectively). One genotype of the D2 dopamine receptor intronic dinucleotide repeat polymorphism (14 repeats/15 repeats, with frequency of 6%) was also associated with earlier dyskinesia (P = 0.003). History of smoking has previously been associated with reduced risk of developing PD. Our results suggest that smoking history may also influence the response to levodopa, with contribution comparable to those of individual genes including the mu opioid receptor and D2 dopamine receptor. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Illinois</li><li>Ohio</li></region></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Strong, Judith A" sort="Strong, Judith A" uniqKey="Strong J" first="Judith A." last="Strong">Judith A. Strong</name></region><name sortKey="Dalvi, Arif" sort="Dalvi, Arif" uniqKey="Dalvi A" first="Arif" last="Dalvi">Arif Dalvi</name><name sortKey="Dalvi, Arif" sort="Dalvi, Arif" uniqKey="Dalvi A" first="Arif" last="Dalvi">Arif Dalvi</name><name sortKey="Gartner, Maureen" sort="Gartner, Maureen" uniqKey="Gartner M" first="Maureen" last="Gartner">Maureen Gartner</name><name sortKey="Gong, Jianhua" sort="Gong, Jianhua" uniqKey="Gong J" first="Jianhua" last="Gong">Jianhua Gong</name><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J." last="Revilla">Fredy J. Revilla</name><name sortKey="Sahay, Alok" sort="Sahay, Alok" uniqKey="Sahay A" first="Alok" last="Sahay">Alok Sahay</name><name sortKey="Samaha, Frederick J" sort="Samaha, Frederick J" uniqKey="Samaha F" first="Frederick J." last="Samaha">Frederick J. Samaha</name><name sortKey="Strong, Judith A" sort="Strong, Judith A" uniqKey="Strong J" first="Judith A." last="Strong">Judith A. Strong</name><name sortKey="Welge, Jeffrey A" sort="Welge, Jeffrey A" uniqKey="Welge J" first="Jeffrey A." last="Welge">Jeffrey A. Welge</name><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><name sortKey="Yue, Xia" sort="Yue, Xia" uniqKey="Yue X" first="Xia" last="Yue">Xia Yue</name></country><country name="Canada"><noRegion><name sortKey="Gong, Jianhua" sort="Gong, Jianhua" uniqKey="Gong J" first="Jianhua" last="Gong">Jianhua Gong</name></noRegion><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003422 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003422 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:975D26BF86995D19483745B7CE4BD0C660AAF62A
|texte= Genotype and smoking history affect risk of levodopa‐induced dyskinesias in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |