MovDisordV3, Main, Merge, bibRecord, 004B81

Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson's disease

Identifieur interne : 004B81 ( Main/Merge ); précédent : 004B80; suivant : 004B82

Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson's disease

Auteurs : Judith A. Strong [États-Unis] ; Arif Dalvi [États-Unis] ; Fredy J. Revilla [États-Unis] ; Alok Sahay [États-Unis] ; Frederick J. Samaha [États-Unis] ; Jeffrey A. Welge [États-Unis] ; JIANHUA GONG [États-Unis] ; Maureen Gartner [États-Unis] ; XIA YUE [États-Unis] ; LEI YU [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0289031

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Tabagisme, Dyskinésie, Parkinson maladie, Génotype, Facteur risque, Lévodopa, Récepteur opiacé, Récepteur dopaminergique D2.
Wicri :
- topic : Tabagisme.

English descriptors

KwdEn :
- D2 Dopamine receptor, Dyskinesia, Genotype, Levodopa, Nervous system diseases, Opioid receptor, Parkinson disease, Risk factor, Tobacco smoking.

Abstract

Parkinson's disease (PD) patients vary widely in their response to levodopa treatment, and this variation may be partially genetic in origin. We determined whether particular dopamine and opioid receptor polymorphisms were associated with risk of earlier onset of dyskinesia side effects during levudopa therapy. Smoking status was also examined. The 92 subjects were recruited from the movement disorders clinic of a neurology practice associated with a medical school. All were adult-onset PD patients who had been taking levodopa at least 5 years and/or had developed levodopa-induced dyskinesia. Carrying the G-allele of the A118G single nucleotide coding region polymorphism of the mu opioid receptor, as well as a history of never smoking, were independently associated with increased risk of earlier onset of dyskinesia (P = 0.05 and 0.02, respectively). One genotype of the D2 dopamine receptor intronic dinucleotide repeat polymorphism (14 repeats/15 repeats, with frequency of 6%) was also associated with earlier dyskinesia (P = 0.003). History of smoking has previously been associated with reduced risk of developing PD. Our results suggest that smoking history may also influence the response to levodopa, with contribution comparable to those of individual genes including the mu opioid receptor and D2 dopamine receptor.

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>D2 Dopamine receptor</term>
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<term>Genotype</term>
<term>Levodopa</term>
<term>Nervous system diseases</term>
<term>Opioid receptor</term>
<term>Parkinson disease</term>
<term>Risk factor</term>
<term>Tobacco smoking</term>
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<term>Tabagisme</term>
<term>Dyskinésie</term>
<term>Parkinson maladie</term>
<term>Génotype</term>
<term>Facteur risque</term>
<term>Lévodopa</term>
<term>Récepteur opiacé</term>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) patients vary widely in their response to levodopa treatment, and this variation may be partially genetic in origin. We determined whether particular dopamine and opioid receptor polymorphisms were associated with risk of earlier onset of dyskinesia side effects during levudopa therapy. Smoking status was also examined. The 92 subjects were recruited from the movement disorders clinic of a neurology practice associated with a medical school. All were adult-onset PD patients who had been taking levodopa at least 5 years and/or had developed levodopa-induced dyskinesia. Carrying the G-allele of the A118G single nucleotide coding region polymorphism of the mu opioid receptor, as well as a history of never smoking, were independently associated with increased risk of earlier onset of dyskinesia (P = 0.05 and 0.02, respectively). One genotype of the D2 dopamine receptor intronic dinucleotide repeat polymorphism (14 repeats/15 repeats, with frequency of 6%) was also associated with earlier dyskinesia (P = 0.003). History of smoking has previously been associated with reduced risk of developing PD. Our results suggest that smoking history may also influence the response to levodopa, with contribution comparable to those of individual genes including the mu opioid receptor and D2 dopamine receptor.</div>
</front>
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<name sortKey="Lei Yu" sort="Lei Yu" uniqKey="Lei Yu" last="Lei Yu">LEI YU</name>
<name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J." last="Revilla">Fredy J. Revilla</name>
<name sortKey="Sahay, Alok" sort="Sahay, Alok" uniqKey="Sahay A" first="Alok" last="Sahay">Alok Sahay</name>
<name sortKey="Samaha, Frederick J" sort="Samaha, Frederick J" uniqKey="Samaha F" first="Frederick J." last="Samaha">Frederick J. Samaha</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson's disease

Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

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Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri