Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson's disease.
Identifieur interne : 001548 ( Ncbi/Checkpoint ); précédent : 001547; suivant : 001549Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson's disease.
Auteurs : Judith A. Strong [États-Unis] ; Arif Dalvi ; Fredy J. Revilla ; Alok Sahay ; Frederick J. Samaha ; Jeffrey A. Welge ; Jianhua Gong ; Maureen Gartner ; Xia Yue ; Lei YuSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antiparkinson Agents (adverse effects), Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (genetics), Female, Follow-Up Studies, Genotype, Humans, Levodopa (adverse effects), Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (genetics), Polymorphism, Genetic, Receptors, Dopamine (genetics), Receptors, Opioid, mu (genetics), Risk, Smoking.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- genetics : Dyskinesia, Drug-Induced, Parkinson Disease, Receptors, Dopamine, Receptors, Opioid, mu.
- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk, Smoking.
Abstract
Parkinson's disease (PD) patients vary widely in their response to levodopa treatment, and this variation may be partially genetic in origin. We determined whether particular dopamine and opioid receptor polymorphisms were associated with risk of earlier onset of dyskinesia side effects during levodopa therapy. Smoking status was also examined. The 92 subjects were recruited from the movement disorders clinic of a neurology practice associated with a medical school. All were adult-onset PD patients who had been taking levodopa at least 5 years and/or had developed levodopa-induced dyskinesia. Carrying the G-allele of the A118G single nucleotide coding region polymorphism of the mu opioid receptor, as well as a history of never smoking, were independently associated with increased risk of earlier onset of dyskinesia (P=0.05 and 0.02, respectively). One genotype of the D2 dopamine receptor intronic dinucleotide repeat polymorphism (14 repeats/15 repeats, with frequency of 6%) was also associated with earlier dyskinesia (P=0.003). History of smoking has previously been associated with reduced risk of developing PD. Our results suggest that smoking history may also influence the response to levodopa, with contribution comparable to those of individual genes including the mu opioid receptor and D2 dopamine receptor.
DOI: 10.1002/mds.20785
PubMed: 16435402
Affiliations:
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Strong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA. judith.strong@uc.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267</wicri:regionArea><wicri:noRegion>Ohio 45267</wicri:noRegion></affiliation></author><author><name sortKey="Dalvi, Arif" sort="Dalvi, Arif" uniqKey="Dalvi A" first="Arif" last="Dalvi">Arif Dalvi</name></author><author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name></author><author><name sortKey="Sahay, Alok" sort="Sahay, Alok" uniqKey="Sahay A" first="Alok" last="Sahay">Alok Sahay</name></author><author><name sortKey="Samaha, Frederick J" sort="Samaha, Frederick J" uniqKey="Samaha F" first="Frederick J" last="Samaha">Frederick J. Samaha</name></author><author><name sortKey="Welge, Jeffrey A" sort="Welge, Jeffrey A" uniqKey="Welge J" first="Jeffrey A" last="Welge">Jeffrey A. Welge</name></author><author><name sortKey="Gong, Jianhua" sort="Gong, Jianhua" uniqKey="Gong J" first="Jianhua" last="Gong">Jianhua Gong</name></author><author><name sortKey="Gartner, Maureen" sort="Gartner, Maureen" uniqKey="Gartner M" first="Maureen" last="Gartner">Maureen Gartner</name></author><author><name sortKey="Yue, Xia" sort="Yue, Xia" uniqKey="Yue X" first="Xia" last="Yue">Xia Yue</name></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20785</idno><idno type="RBID">pubmed:16435402</idno><idno type="pmid">16435402</idno><idno type="wicri:Area/PubMed/Corpus">002D81</idno><idno type="wicri:Area/PubMed/Curation">002D81</idno><idno type="wicri:Area/PubMed/Checkpoint">002D13</idno><idno type="wicri:Area/Ncbi/Merge">001548</idno><idno type="wicri:Area/Ncbi/Curation">001548</idno><idno type="wicri:Area/Ncbi/Checkpoint">001548</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson's disease.</title><author><name sortKey="Strong, Judith A" sort="Strong, Judith A" uniqKey="Strong J" first="Judith A" last="Strong">Judith A. Strong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA. judith.strong@uc.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267</wicri:regionArea><wicri:noRegion>Ohio 45267</wicri:noRegion></affiliation></author><author><name sortKey="Dalvi, Arif" sort="Dalvi, Arif" uniqKey="Dalvi A" first="Arif" last="Dalvi">Arif Dalvi</name></author><author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name></author><author><name sortKey="Sahay, Alok" sort="Sahay, Alok" uniqKey="Sahay A" first="Alok" last="Sahay">Alok Sahay</name></author><author><name sortKey="Samaha, Frederick J" sort="Samaha, Frederick J" uniqKey="Samaha F" first="Frederick J" last="Samaha">Frederick J. Samaha</name></author><author><name sortKey="Welge, Jeffrey A" sort="Welge, Jeffrey A" uniqKey="Welge J" first="Jeffrey A" last="Welge">Jeffrey A. Welge</name></author><author><name sortKey="Gong, Jianhua" sort="Gong, Jianhua" uniqKey="Gong J" first="Jianhua" last="Gong">Jianhua Gong</name></author><author><name sortKey="Gartner, Maureen" sort="Gartner, Maureen" uniqKey="Gartner M" first="Maureen" last="Gartner">Maureen Gartner</name></author><author><name sortKey="Yue, Xia" sort="Yue, Xia" uniqKey="Yue X" first="Xia" last="Yue">Xia Yue</name></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiparkinson Agents (adverse effects)</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Dyskinesia, Drug-Induced (genetics)</term><term>Female</term><term>Follow-Up Studies</term><term>Genotype</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Genetic</term><term>Receptors, Dopamine (genetics)</term><term>Receptors, Opioid, mu (genetics)</term><term>Risk</term><term>Smoking</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease</term><term>Receptors, Dopamine</term><term>Receptors, Opioid, mu</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Follow-Up Studies</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Genetic</term><term>Risk</term><term>Smoking</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) patients vary widely in their response to levodopa treatment, and this variation may be partially genetic in origin. We determined whether particular dopamine and opioid receptor polymorphisms were associated with risk of earlier onset of dyskinesia side effects during levodopa therapy. Smoking status was also examined. The 92 subjects were recruited from the movement disorders clinic of a neurology practice associated with a medical school. All were adult-onset PD patients who had been taking levodopa at least 5 years and/or had developed levodopa-induced dyskinesia. Carrying the G-allele of the A118G single nucleotide coding region polymorphism of the mu opioid receptor, as well as a history of never smoking, were independently associated with increased risk of earlier onset of dyskinesia (P=0.05 and 0.02, respectively). One genotype of the D2 dopamine receptor intronic dinucleotide repeat polymorphism (14 repeats/15 repeats, with frequency of 6%) was also associated with earlier dyskinesia (P=0.003). History of smoking has previously been associated with reduced risk of developing PD. Our results suggest that smoking history may also influence the response to levodopa, with contribution comparable to those of individual genes including the mu opioid receptor and D2 dopamine receptor.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Dalvi, Arif" sort="Dalvi, Arif" uniqKey="Dalvi A" first="Arif" last="Dalvi">Arif Dalvi</name><name sortKey="Gartner, Maureen" sort="Gartner, Maureen" uniqKey="Gartner M" first="Maureen" last="Gartner">Maureen Gartner</name><name sortKey="Gong, Jianhua" sort="Gong, Jianhua" uniqKey="Gong J" first="Jianhua" last="Gong">Jianhua Gong</name><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name><name sortKey="Sahay, Alok" sort="Sahay, Alok" uniqKey="Sahay A" first="Alok" last="Sahay">Alok Sahay</name><name sortKey="Samaha, Frederick J" sort="Samaha, Frederick J" uniqKey="Samaha F" first="Frederick J" last="Samaha">Frederick J. Samaha</name><name sortKey="Welge, Jeffrey A" sort="Welge, Jeffrey A" uniqKey="Welge J" first="Jeffrey A" last="Welge">Jeffrey A. Welge</name><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><name sortKey="Yue, Xia" sort="Yue, Xia" uniqKey="Yue X" first="Xia" last="Yue">Xia Yue</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Strong, Judith A" sort="Strong, Judith A" uniqKey="Strong J" first="Judith A" last="Strong">Judith A. Strong</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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